Antidiabetic and ameliorative potential of Ficus bengalensis bark extract in streptozotocin induced diabetic rats

Abstract

The aim of the present study was to evaluate the antidiabetic and ameliorative potential of aqueous extract of Ficus bengalensis bark in streptozotocin induced diabetic rats. The effect of oral administration of aqueous extract of F. bengalensis bark on blood glucose, serum electrolytes, serum glycolytic enzymes, liver microsomal protein, hepatic cytochrome P-450 dependent monooxygenase enzymes and lipid peroxidation in liver and kidney of streptozotocin -induced diabetic rats was studied. Oral administration of Ficus bengalensis to fed, fasted and glucose loaded diabetic rats significantly [F > 0.05 (ANOVA) and P< 0.05 (DMRT)] decreased the blood glucose level at 5 hrs and restored the levels of serum electrolytes, glycolytic enzymes and hepatic cytochrome P-450 dependent enzyme systems and decreased the formation of liver and kidney lipid peroxides at the end of 12 weeks. Further, the aqueous extract of Ficus bengalensis at a dose of 500mg/kg/day exhibits significant antidiabetic and ameliorative activity as evidenced by histological studies in normal and Ficus bengalensis treated streptozotocin induced diabetic rats. On the basis of our findings, it could be used as an antidiabetic and ameliorative agent for better management of diabetes mellitus.

Modulatory effect of S-allylcysteine on glucose metabolism in streptozotocin induced diabetic rats

“…Intraperitoneal administration of streptozotocin effectively induced diabetes in normal rats, as observed by hyperglycemia when compared with normal rats. Persistent hyperglycemia, the common characteristic of diabetes can cause most diabetic complications and it is normalized by the action of insulin (Gayathri and Kannabiran, 2008). In the present study, it was observed that oral administration of SAC could reverse the above mentioned diabetic effect, possibly due to an insulinlike effect of SAC on peripheral tissues, either by promoting glucose uptake and metabolism, or by inhibiting hepatic gluconeogenesis.…”

“…It has been reported that STZ-induced diabetes produces partial or total deficiency of insulin that results in decreasing the activity of glycogen synthase and increasing the activity of glycogen phosphorylase (Gayathri and Kannabiran, 2008) leads to decreasing the storage of tissue glycogen (Senthil Kumar et al, 2006). Administration of SAC and glyclazide to diabetic rats restored the level of liver glycogen by decreasing glycogen phosphorylase activity and increasing glycogen synthase activity.…”

Enhanced antibacterial activity of streptomycin against some human pathogens using green synthesized silver nanoparticles

“…It is used in diabetes, diarrhea, leucorrhoea, menorrhea, nervous disorder, vaginal diseases, in the treatment of skin diseases, ulcer and soreness in the mouth etc. [30,31]. F. virens possess antioxidant properties [32][33][34] and do not show any toxicity even at higher and repeated doses [35].…”

Phytohormone Induced Changes on Bone Histology in Normal and Diabetic Male Rat

“…This could be the reason for the altered electrolyte balance in diabetic rat, which resulted in the elevated serum sodium, potassium and calcium in STZ-induced diabetic rats. However, administration of 28-HC reduced the glucose level and restored tissue electrolytes and this can be the possible cause for the reduction of the serum electrolytes levels [16].…”