Antidiabetic and aldose reductase activities of biflavanones ofGarcinia kola

Abstract

Kolaviron, a mixture of C-3/C-8 linked biflavonoids obtained from Garcinia kola produces significant hypoglycaemic effects when administered intraperitoneally to normal and alloxan diabetic rabbits at a dose of 100 mg kg-1. The fasting blood sugar in normoglycaemic rabbits was reduced from 115 mg/100 mL to 65 mg/100 mL after 4 h. In alloxan diabetic rabbits, the blood sugar was lowered from 506 mg/100 mL to 285 mg/100 mL at 12 h. The hypoglycaemic effects have been compared with those of tolbutamide. Kolaviron inhibited rat lens aldose reductase (RLAR) activity, with an IC50 value of 5.4 x 10(-6). The significance of these findings in the potential use of kolaviron as an antidiabetic agent is discussed.

Neuroprotective Effects of Kolaviron, a Biflavonoid Complex of <i>Garcinia kola</i>, on Rats Hippocampus against Methamphetamine-Induced Neurotoxicity

“…Kolaviron (KV) (Figure 1), the predominant constituent in G. kola, contains biflavanones (GB1, GB2 and kolaflavanone) and has been reported to prevent hepatotoxicity mediated by several toxins [6,8,9]. Likewise, kolaviron exhibited hypoglycemic effects in normal and alloxan-and streptozotocin-induced diabetic animals [10,11]. Also, kolaviron has been reported to elicit strong antioxidant activity, both in vivo and in vitro experimental models [12].…”

In Vitro Antioxidant Activities of Ethanolic Extract and Triterpenoid Fraction of Garcinia Kola Stem Bark and Inhibition of Arsenic-Induced Rat Liver and Kidney Mitochondrial Membrane Permeability Transitions.

“…It is a perennial crop that is distributed throughout West and Central Africa (Iwu et al, 2009;Farombi and Owoeye, 2011). G. kola is a medium sized evergreen tree that is about 15 -17 m tall with a fairly narrow crown.…”

Endothelium-independent vasodilation induced by kolaviron, a biflavonoid complex from Garcinia kola seeds, in rat superior mesenteric arteries

“…Three kilogram of peeled seeds was sliced, pulverized with an electric blender and air-dried in the laboratory (25-28°C). Extraction of KV was achieved by the methods of Cotterhill et al (1978) and Iwu et al (1990). Briefly, powdered seeds were extracted with light petroleum ether (bp 40-60°C) in a soxhlet extractor.…”

“…Kolaviron (KV), the predominant constituent in Garcinia kola is a biflavonoid complex that has been reported to prevent hepatotoxicity mediated by several toxins (Iwu et al, 1987;Adaramoye and Adeyemi, 2006a). Likewise, KV is known to exhibit hypoglycemic effects in normal, alloxan and streptozotocin-diabetic animals (Iwu et al, 1990;Adaramoye and Adeyemi, 2006b). Also, KV has been reported to elicit strong antioxidant activity in both in vivo and in vitro experimental models (Adaramoye et al, 2005a).…”