Antidiabetic activity of Tephrosia tinctoria in Alloxan induced Diabetic Rats: A Preliminary Study

Abstract

Plant derived products play a vital role in preventing and treating various disease in humans. Tephrosia tinctoria is a plant belonging to the family Leguminosae, found to have antidiabetic and antioxidant activities. The study was aimed to investigate the anti-diabetic and anti-oxidant activity of whole plant of Tephrosia tinctoria in diabetic rats. Alloxan induced model was used to induce Diabetes. The chloroform and ethanolic extracts of Tephrosia tinctoria (CETT and EETT) at the dose of 250 and 500mg/kg b.w were administered orally at single dose per day to diabetic rats. Glipizide 5mg/kg b.w was used as standard drug. The general body weight, insulin level, blood glucose, serum lipid profile, superoxide dismutase, and lipid peroxidation assays were the parameters evaluated in diabetic rats. EETT have better anti-diabetic and anti-oxidant activity than CETT. The protective effects were even confirmed by histopathological studies. These observations show that both the extracts were effective in possessing the significant antidiabetic and antioxidant properties in alloxan induced diabetes.

In vivo and in vitro Hyperglycaemic Screening of Adenocalymma alliaceum Miers, A Promising Herb

“…Alloxan is responsible for pancreatic β-cell damage, resulting in diminished insulin secretion. 26 Alloxan raises the fasting blood glucose levels significantly in laboratory animals. It is due to pancreatic β-cell toxicity and subsequent insulin insufficiency.…”