Antidiabetic activity of Syzygium calophyllifolium in Streptozotocin-Nicotinamide induced Type-2 diabetic rats

Chandran, Rahul; Thangaraj, Parimelazhagan; Saravanan, S.; Sajeesh, Thankarajan

doi:10.1016/j.biopha.2016.05.036

Cited by 68 publications

(44 citation statements)

References 19 publications

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“…However, these drugs have not been effective in combating the progression of DN. In additional several reported side effects have been associated with these drugs (Chandran, Parimelazhagan, Shanmugam, & Thankarajan, ; Seo, Kang, Oh, & Jun, ). Therefore, the development of new drugs that act on various components of DN is urgently required.…”

Section: Introductionmentioning

confidence: 99%

Rhinacanthins‐rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin‐nicotinamide‐induced diabetic nephropathy

et al. 2019

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In this present study, rhinacanthins‐rich extract (RRE) and rhinacanthin C (RC) the main bioactive constituent of Rhinacanthus nasutus was investigated for their protective effect against diabetic nephropathy (DN). Diabetes was induced by administering nicotinamide (100 mg/kg, i.p.)/streptozotocin (60 mg/kg, i.p.) and diabetic rats were orally administered with RRE and RC for 4 weeks. RRE and RC significantly reduced the kidney index, renal oxidative stress markers, and pro‐inflammatory cytokines. Furthermore, RRE and RC increased renal levels of glutathione, superoxide dismutase, catalase, and attenuated diabetic induced renal damages. In conclusion, RRE and RC confer protective effect against DN through the inhibition of oxidative stress and inflammation and could be a potential medicinal or nutritional supplement for the prevention of DN. Practical applications Rhinacanthus nasutus is a medicinal plant that is extensively used in Thai traditional medicine as an antibacterial, antifungal, antidiabetic, and anti‐inflammatory agent. The plant is rich in naphthoquinones, which confer it with several excellent bioactivities. The rich extract of the leaves was prepared with three major bioactive components and the extract was evaluated for its renoprotective effect in diabetic rats. The results from this study provides valuable pharmacological information that supports the use of the plant, especially the rich extract in the prevention and treatment of diabetes and diabetic complications.

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Section: Introductionmentioning

confidence: 99%

Rhinacanthins‐rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin‐nicotinamide‐induced diabetic nephropathy

et al. 2019

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“…[7][8] Type 2 diabetes mellitus (T2DM) accounts for 90 -95% of the global diabetic population. [14] Thus, the focus on natural remedies which are considerably safer and more accessible as promising alternatives for the treatment of diabetes is imperative. [9] [10] The management of diabetes mellitus is focused on regulating the blood glucose level so as to delay or impede the associated diabetic complications.…”

Section: Introductionmentioning

confidence: 99%

“…[13] In addition, WHO has also encouraged the use of traditional medicinal plants for the treatment of diabetes due to their effectiveness and safety. [14] Thus, the focus on natural remedies which are considerably safer and more accessible as promising alternatives for the treatment of diabetes is imperative. [15] A sizeable number of medicinal plants are used in Thai traditional medicinal system and have been reported to have scientific significance as sources of antidiabetic agents.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of In Vitro α‐Amylase and α‐Glucosidase Inhibitory Potentials of 14 Medicinal Plants Constituted in Thai Folk Antidiabetic Formularies

Somtimuang

Olatunji

Ovatlarnporn³

2018

Chemistry & Biodiversity

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The sporadic increase in the occurrence and prevalence of diabetes mellitus have compelled and vigorous search for alternative anti-diabetic therapeutic approach from medicinal plants and its bioactive. One of the major approach employed is the reduction of gastrointestinal glucose levels through the inhibition of carbohydrate digesting enzymes notably α-amylase and α-glucosidase. In this study, the ethanol extracts of 14 selected plants from Mor Porn's recipe were screened for their α-amylase and α-glucosidase inhibitory activity. The ethanolic extract from the stem of Vitex glabrata displayed the highest percentage inhibitory activity of 84.98 ± 0.59 and 84.71 ± 1.51 against α-glucosidase and α-amylase enzymes, respectively. Chemical investigation of the active extract of V. glabrata indicated that pentacyclic triterpenes were the major compounds responsible for the activity. The result obtained from this study suggests the potential use of V. glabrata as an alternative natural source for the treatment of diabetes mellitus.

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“…Weight was checked before and after STZ injection. One week after STZ injection, diabetes was confirmed by measuring fasting blood glucose levels from the tail vein using Accu-Chek glucometer (Roche; Stuttgart, Germany) (Chandran et al, 2016). Only animals with fasting plasma glucose level above 200 mg/dl were chosen for the experiment.…”

Section: Induction Of Diabetesmentioning

confidence: 99%

Effect of Quercetin on Beta cell Regeneration

Gurav¹,

Bhise²,

Warghade³

2018

Asian J Pharm Pharmacol

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Antidiabetic activity of Syzygium calophyllifolium in Streptozotocin-Nicotinamide induced Type-2 diabetic rats

Cited by 68 publications

References 19 publications

Rhinacanthins‐rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin‐nicotinamide‐induced diabetic nephropathy

Rhinacanthins‐rich extract and rhinacanthin C ameliorate oxidative stress and inflammation in streptozotocin‐nicotinamide‐induced diabetic nephropathy

Evaluation of In Vitro α‐Amylase and α‐Glucosidase Inhibitory Potentials of 14 Medicinal Plants Constituted in Thai Folk Antidiabetic Formularies

Effect of Quercetin on Beta cell Regeneration

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