Antidiabetic activity of Piper auritum leaves in streptozotocin-induced diabetic rat, beneficial effect on advanced glycation endproduct

González, Alina Alerm; Gutierrez, Rosa Martha Pérez; Cotera, Luis Bernardo Flores

doi:10.1007/s11655-014-1753-2

Cited by 5 publications

(2 citation statements)

References 25 publications

(18 reference statements)

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“…This compound could be responsible for the antiparasitic activity of this plant [ 133 ]. On the other hand, Piper auritum has demonstrated positive effects on diabetes, cholesterol and triglycerides [ 134 , 135 ]. Moreover, the administration of P. auritum did not reduce carrageenan-induced paw edema in rats [ 136 ].…”

Section: Preclinical Studies Of Mexican Medicinal Plants Used In Inflammatory and Neuropathic Pain Treatmentmentioning

confidence: 99%

Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

Quiñonez-Bastidas

Navarrete

2021

Plants

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Despite the availability of many anti-pain drugs, in the form of NSAIDs, steroids, gabapentinoids, opioids, and antidepressants, in this study we address the natural compounds belonging to the group of Mexican medicinal plants or “Mexican folk medicine”, used for pain management in Mexico. Our interest in this subject is due to the growing idea that “natural is harmless” and to the large number of side effects exhibited in pharmacotherapy. The objective of this review was to document the scientific evidence about Mexican medicinal plants and their derivatives used for inflammatory and neuropathic pain treatment, as well as the mechanisms of action implicated in their antinociceptive effects, their possible adverse effects, and the main pharmacological aspects of each plant or compound. Our data review suggested that most studies on Mexican medicinal plants have used inflammatory experimental models for testing. The anti-pain properties exerted by medicinal plants lack adverse effects, and their toxicological assays report that they are safe to consume; therefore, more studies should be performed on preclinical neuropathic pain models. Moreover, there is no convincing evidence about the possible mechanisms of action involved in the anti-pain properties exerted by Mexican plants. Therefore, the isolation and pharmacological characterization of these plant derivatives’ compounds will be important in the design of future preclinical studies.

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Section: Preclinical Studies Of Mexican Medicinal Plants Used In Inflammatory and Neuropathic Pain Treatmentmentioning

confidence: 99%

Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

Quiñonez-Bastidas

Navarrete

2021

Plants

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“…Piper auritum (Piperaceae) leaves are used for treatment of diabetes in many Latin American countries . Our previous studies have shown that extracts of P. auritum inhibit the formation of AGEs. − Overall, P. auritum was found to significantly inhibit protein glycation in vitro and to decrease AGE formation and glycosylated hemoglobin in diabetic rats. However, despite the fact that a number of compounds with different biological activities (mainly alkaloids) have been isolated from P. auritum , the chemical identities of the antiglycation metabolites responsible for the putative pharmacological antidiabetic activity of this plant remain to be discovered.…”

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confidence: 95%

Phylogenomics of 2,4-Diacetylphloroglucinol-Producing Pseudomonas and Novel Antiglycation Endophytes from Piper auritum

et al. 2017

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2,4-Diacetylphloroglucinol (DAPG) (1) is a phenolic polyketide produced by some plant-associated Pseudomonas species, with many biological activities and ecological functions. Here, we aimed at reconstructing the natural history of DAPG using phylogenomics focused at its biosynthetic gene cluster or phl genes. In addition to around 1500 publically available genomes, we obtained and analyzed the sequences of nine novel Pseudomonas endophytes isolated from the antidiabetic medicinal plant Piper auritum. We found that 29 organisms belonging to six Pseudomonas species contain the phl genes at different frequencies depending on the species. The evolution of the phl genes was then reconstructed, leading to at least two clades postulated to correlate with the known chemical diversity surrounding DAPG biosynthesis. Moreover, two of the newly obtained Pseudomonas endophytes with high antiglycation activity were shown to exert their inhibitory activity against the formation of advanced glycation end-products via DAPG and related congeners. Its isomer, 5-hydroxyferulic acid (2), detected during bioactivity-guided fractionation, together with other DAPG congeners, were found to enhance the detected inhibitory activity. This report provides evidence of a link between the evolution and chemical diversity of DAPG and congeners.

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Glucokinase activation as antidiabetic therapy: effect of nutraceuticals and phytochemicals on glucokinase gene expression and enzymatic activity

Guzmán

Gurrola-Díaz

2019

Archives of Physiology and Biochemistry

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Antidiabetic activity of Piper auritum leaves in streptozotocin-induced diabetic rat, beneficial effect on advanced glycation endproduct

Cited by 5 publications

References 25 publications

Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

Phylogenomics of 2,4-Diacetylphloroglucinol-Producing Pseudomonas and Novel Antiglycation Endophytes from Piper auritum

Glucokinase activation as antidiabetic therapy: effect of nutraceuticals and phytochemicals on glucokinase gene expression and enzymatic activity

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