Antidiabetic Activity of Ethanolic Extract of Kalanchoe Pinnata Leaves in Alloxan Induced Hyperglycaemic Rats.

Dd, Indah

doi:10.14499/indonesianjpharm27iss3pp139

Cited by 5 publications

(1 citation statement)

References 11 publications

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“…After the treatment, the fasting blood glucose of the rats was recorded every day for 5 days; the animals were sacrificed at the end of the study for histopathological examination. The extract significantly lowered the fasting blood glucose (p < 0.05) and increased the number of pancreatic beta Langerhans cells, albeit not in a dose-dependent manner [62]. Kalanchoe pinnata has anti-oxidative, as well as α-amylaseand α-glucosidase-inhibitory activities, which enhance glucose uptake, thereby indicating its antidiabetic potential [160].…”

Section: Kalanchoe Pinnatamentioning

confidence: 99%

Diabetes Mellitus Management: An Extensive Review of 37 Medicinal Plants

Zanzabil,

Hossain,

Hasan

2023

Diabetology

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Plants have been used as sources of medicine since ancient times. Natural products have been used extensively in Chinese, ayurvedic and folk medicine. In addition, a significant portion of the world’s population still utilizes herbal medicine. Diabetes is a common ailment affecting almost 463 million people in the world. However, current medications exert harmful after-effects on patients, while herbal medicines have fewer adverse effects. Plants possess secondary metabolites, such as alkaloids, flavonoids, tannins, steroids, etc., which exert numerous beneficial effects on health. Extensive research has been conducted over the years investigating and proving the hypoglycemic potential of various plants. The present paper reviews 37 such plants that are rich in phytoconstituents that possess a variety of pharmacological activities and have been experimentally proven to possess potentially hypoglycemic properties in animal models: Ficus racemosa, Agremone mexicana, Bombax ceiba, Cajanus cajan, Coccinia cordifolia, Momordica charantia, Syzygium cumini, Neolamarckia cadamba, Mangifera indica, Cocos nucifera, Tamarindus indica, Punica granatum, Azadirachta indica, Costus speciosus, Moringa oleifera, Andrographis paniculata, Ficus benghalensis, Anacardium occidentale, Annona squamosa, Boerhaavia diffusa, Catharanthus roseus, Cocculus hirsutus, Ficus hispida, Terminalia chebula, Terminalia catappa, Amaranthus tricolor, Blumea lacera, Piper betle leaves, Achyranthes aspera, Kalanchoe pinnata, Nelumbo nucifera, Mikania cordata, Wedelia chinensis, Murraya koenigii, Aloe barbadensis, Bryophyllum pinnatum and Asparagus racemosus. These 37 plant extracts exhibit antidiabetic activities through different mechanisms, including α-amylase and α-glucosidase inhibition, increases in glucose uptake and the stimulation of insulin secretion.

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Section: Kalanchoe Pinnatamentioning

confidence: 99%

Diabetes Mellitus Management: An Extensive Review of 37 Medicinal Plants

Zanzabil,

Hossain,

Hasan

2023

Diabetology

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The effect of n-butanol fraction of gaharu (Aquilaria microcarpa Baill.) leaves on blood glucose and liver glycogen levels in alloxan-induced male rats

Anwar

Juliantie

Nurlely

2022

IOP Conf. Ser.: Earth Environ. Sci.

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Gaharu leaves (Aquilaria microcarpa Baill.) empirically used to lower blood glucose levels by people of Tamiang Layang Cental Kalimantan. This study measured the activity of A. microcarpa leaves to blood glucose and glycogen liver levels. The study used 24 male white rats. Animal test were divided into 6 groups (n=4) receiving different treatments: normal control, negative control (vehicle), positive control (glibenclamide 0,45 mg/kg BW), n-butanol fraction (12.5 mg/kg BW; 25 mg/kg BW; and 50 mg/kg BW). All groups, excluding the normal group, were induced by alloxan monohydrate (150 mg/kg BW, i.p.). After 72 hours, the levels of glucose blood were measured and the treatment was administered. Pre-prandial and postprandial measurement of blood glucose levels were conducted on days 0, 7, and 14 after treatment. On day 15th the liver was extracted out and analyzed by UV-Vis spectrophotometry to determine the glycogen levels. The results of this study showed that bood glucose levels reduction and liver glycogen levels enhancement of n-butanol fraction of A. microcarpa leaves at the doses of 12.5; 25 and 50 mg/kg BW significantly different with the negative control (p < 0.05). This result suggests n-butanol fraction of A. microcarpa leaves has potensial as an antidiabetic agent.

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Antidiabetic Potency of Bangladeshi Medicinal Plants

Hasan¹,

Sultana²

2018

J. Ayu. Her. Med.

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Diabetes mellitus is a degenerative disease being responsible for about 1.5 million deaths globally. In Bangladesh, the stress of diabetes is on rising and resulting in serious health implications along with significant economic crisis. Due to undesirable and inherent side effects, researchers are now shifting from the conventional therapy and trying to prevent and manage diabetes through traditional medicine. World Health Organization (WHO) also recommends the practice of customary herbal medicine for diabetes management, and support and encourage the augmentation of research to evaluate the hypoglycemic properties of the diverse medicinal plant species. Consequently, in the current review, the antihyperglycemic potency of some Bangladeshi medicinal plants has been evaluated and verified utilizing human as well as experimental animals. The results elucidate the glucose-lowering effects of the plants via different cellular mechanisms, including restoration of pancreatic β-cell, controlling the action of carbohydrate metabolizing enzymes, enhancing peripheral glucose utilization, increase in muscle glycogen store as well as activation of the insulin signaling cascade. In summary, this work may invigorate the researchers for more specific and focused research to provide a better and broad understanding of the antihyperglycemic mechanism and can act as an effective tool for choosing the plants with robust potential for unbolting of novel antidiabetic agents.

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Antidiabetic Activity of Ethanolic Extract of Kalanchoe Pinnata Leaves in Alloxan Induced Hyperglycaemic Rats.

Cited by 5 publications

References 11 publications

Diabetes Mellitus Management: An Extensive Review of 37 Medicinal Plants

Diabetes Mellitus Management: An Extensive Review of 37 Medicinal Plants

The effect of n-butanol fraction of gaharu (Aquilaria microcarpa Baill.) leaves on blood glucose and liver glycogen levels in alloxan-induced male rats

Antidiabetic Potency of Bangladeshi Medicinal Plants

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