Antidiabetic activity of Cassia occidentalis (Linn) in normal and alloxan-induced diabetic rats

Verma, Laxmi; Khatri, Anirudh; Kaushik, Basant; Patil, U. K.; Pawar, Rajesh Singh

doi:10.4103/0253-7613.68422

Cited by 56 publications

(54 citation statements)

References 10 publications

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“…Similar effects have been recorded in other studies using the leaves of Cassia occidentalis alone [27], the flower only [28]. The nature of changes observed in the groups treated with standard drug and that of 400 mg/kg body weight is more pronounced than those treated with 200 mg/kg body weight, that is to say this significant changes in the lipid parameters were dose dependant.…”

Section: Discussionsupporting

confidence: 86%

Ameliorative Effect of Methanolic Extract of Cassiaoccidentalis (MECO) Whole Plant, on Triton X-100-Induced Hyperlipidaemia in Albino Rats

2016

IJSR

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This study revealed the evaluation of phytochemicals and ameliorative effect of methanolic whole plant extract of Cassia occidantalis (MECO) on triton X-100-induced hyperlipidaemia in albino rats. Qualitative phytochemical analysis of MECO was conducted using standard methods. In hyperlipidemic model, the rats were divided into five groups, where hyperlipidaemia was induced to all groups with the exception of normal control group which received only normal saline instead. On completion of 14 days of treatment with MECO and Simvastatin (Standard drug) on the hyperlipidemic rats, blood was collected through cardiac puncture for estimation of serum lipid profile with subsequent cervical dislocation of the rats. Qualitatively, MECO shows variety of phytochemicals including flavonoids, saponins, tannins, anthraquinones, cardenolides, and alkaloids. Upon administration of 250-2000 mg/kg body weight of the extracts for acute toxicity test, there was no any observable behaviour change and or mortality recorded. Both the two doses (200 and 400 mg/kg body weight) of MECO in the treatment of hyperlipidaemia show significant (p<0.05) increased in serum high-density lipoprotein cholesterol (HDL-c) and decreased in total cholesterol (TC), triglycerides TG), very low-density lipoproteins (VLDL-c) as well as low-density lipoproteins (LDL-c) in test groups as compared to untreated hyperlipidemic groups. It can therefore, be concluded that MECO whole plant maintain lipid homeostasis by restoring the abnormal level of serum lipid profile back to normal and thereby minimizing the risk of coronary heart diseases and their associates in hyperlipidemic albino rats.

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Section: Discussionsupporting

confidence: 86%

Ameliorative Effect of Methanolic Extract of Cassiaoccidentalis (MECO) Whole Plant, on Triton X-100-Induced Hyperlipidaemia in Albino Rats

2016

IJSR

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“…Group 2 rats received 2 mg/kg glibenclamide as a reference drug while groups 3, 4, and 5 rats were administered 50, 100, and 150 mg/kg GLE, respectively, through gastric gavage. The drug or extract and the vehicle were administered to the rats for 21 d. The FBS levels and the body weights of the rats were measured on days 0, 1, 7, 14, and 21 (Verma et al, 2010). On day 21, being the last day of the treatment, blood samples were collected from the retro-orbital plexus of the eye under light ether anesthesia for serum biochemistry, lipid peroxidation/in vivo antioxidant activities.…”

Section: Ferric-reducing Antioxidant Power Assaymentioning

confidence: 99%

Antidiabetic, antilipidemic, and antioxidant activities ofGouania longipetalamethanol leaf extract in alloxan-induced diabetic rats

Ezeja

Anaga

Asuzu

2014

Pharmaceutical Biology

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Context: Gouania longipetala Hemsl. (Rhamnaceae) is used in folkloric medicine for treating diabetes mellitus and its associated symptoms. Objective: This study evaluated the antidiabetic antilipidemic and antioxidant activities of the plant methanol leaf extract. Materials and methods: Diabetes was induced in rats by intraperitoneal injection of alloxan monohydrate (160 mg/kg). Three test doses (50, 100, and 150 mg/kg) of G. longipetala extract (GLE) were administered orally and the effects were compared with glibenclamide (2 mg/kg). The effect of GLE on hyperglycemia and sub-acute study for 21 d were carried out using its effect on fasting blood sugar (FBS) level. Serum biochemistry and antioxidant activity were evaluated. Histopathological evaluation of the pancreas was also done. Results: The LD 50 of G. longipetala was found to be 44000 mg/kg. The extract significantly (p50.0001) decreased the FBS levels of treated rats from 16.2 ± 2.03 to 6.5 ± 1.52 mM/L at 150 mg/kg within 24 h. The extract decreased FBS levels of rats by 62.0, 74.8, and 75.0% on day 21 at 50, 100, and 150 mg/kg, respectively. GLE reduced the level of malondiadehyde from 23.0 ± 1.34 to 10.3 ± 0.43 mg/dL, increased superoxide dismutase activities from 2.97 ± 0.34 to 5.80 ± 0.53 IU/L at 150 mg/kg, and improved the serum lipid profile of treated rats. GLE also caused restoration of the altered histopathological changes of the pancreas. Discussion and conclusion: Gouania longipetala demonstrated significant antidiabetic, antilipidemic, and antioxidant activities that may be due to its multiple effects involving both pancreatic and extra-pancreatic mechanisms.

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“…It is used for fever, menstrual problems, tuberculosis and as a tonic for general weakness and illness [59]. Cassia occidentalis leaf extracts have antibacterial [60][61][62], antiplasmodial [63], antimutagenic [64], hepatoprotective [65] and anti-diabetic activity [66]. The plant was also evaluated for the antianxiety and antidepressant activity [67].…”

Section: Cassia Occidentalismmentioning

confidence: 99%

A Review Study on the Traditional Plants has Potential Antidepressant Property

Rahman¹

2017

MOJCSR

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DiscussionThis review includes detailed description of antidepressant activity of 21 medicinal plants whose roots, leaves, fruits extracts were used to evaluate the activity from various research articles.The tests employed for antidepressant activity includes HBT, FST, TST, OFT, EPMT, and MACT using rotarod and THB. These tests are employed with slight modification from original method, keeping basic concept same. HBTExploratory behaviour of rodents such as mice is evaluated using hole board test. The floor of the apparatus has regularly arranged holes. The animal is placed in the arena. Both frequency and duration of spontaneous elicited hole-poking behavior are then measured during a short period of time. This test also provides a simple method for assessing anxious response of a rodent to an unfamiliar environment. The use of the hole-board in this perspective relies on the hypothesis that the behavior of animals exposed to a novel situation results from competition AbstractDepression refers to a state of low mood and aversion to activity characterized by depressed mood, loss of interest, reduced energy and concentration. The reasons for the disease include stimulation of MAO-A, inhibition of NA and 5-HT. Symptoms include the diminished interest of pleasure, feelings of worthlessness or inappropriate guilt, a decrease in appetite and libido, insomnia, and recurrent thoughts of death or suicide. There are plenty of synthetic drugs used to treat depression but not enough blissful for patients, moreover, these synthetic drugs have potential side effects. After decades of serious obsession with the modern medicinal system, people have started looking at the ancient healing systems like Ayurveda, Siddha, and Unani. Many scientists are researching plant material for treating this disorder and there are lots of publications on it. But this is not sufficient for treating depression; further outcome should come into light that's the purpose of our review.

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Antidiabetic activity of Cassia occidentalis (Linn) in normal and alloxan-induced diabetic rats

Cited by 56 publications

References 10 publications

Ameliorative Effect of Methanolic Extract of Cassiaoccidentalis (MECO) Whole Plant, on Triton X-100-Induced Hyperlipidaemia in Albino Rats

Ameliorative Effect of Methanolic Extract of Cassiaoccidentalis (MECO) Whole Plant, on Triton X-100-Induced Hyperlipidaemia in Albino Rats

Antidiabetic, antilipidemic, and antioxidant activities ofGouania longipetalamethanol leaf extract in alloxan-induced diabetic rats

A Review Study on the Traditional Plants has Potential Antidepressant Property

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