Antidiabetic activity of a xanthone compound, mangiferin

Miura, Toshihiro; Ichiki, Hiroyuki; Hashimoto, Itsuko; Iwamoto, Naoki; Kao, Motoshi; Kubo, Masayoshi; Ishihara, Eriko; Komatsu, Yasuhiro; Okada, Minoru; Ishida, Tatsuro; Tanigawa, Keiichro

doi:10.1078/0944-7113-00009

Cited by 172 publications

(95 citation statements)

References 9 publications

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“…47) The mangiferin exerts antidiabetic properties by decreasing insulin resistance in non-insulin dependent KK/Ay mice. 19) The chronic administration of mangiferin significantly improved oral glucose tolerance in glucose-loaded normal rats. 48) In conclusion, the administration of mangiferin is a significant restoration of the blood glucose, glycosylated hemoglobin, and carbohydrate metabolizing enzymes such as hexokinase, pyruvate kinase, glycogen synthase, lactate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, and glycogen synthase.…”

Section: Discussionmentioning

confidence: 99%

Antihyperglycemic Effect of Mangiferin in Streptozotocin Induced Diabetic Rats

Sellamuthu

Muniappan

Perumal

et al. 2009

JOURNAL OF HEALTH SCIENCE

100

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The study was undertaken to evaluate the antihyperglycemic potential of mangiferin purified from methanolic root extract of Salacia chinensis (S. chinensis) in control and streptozotocin (STZ)-induced diabetic rats. The mangiferin was administered orally at a dose of 40 mg/kg weight per day (30 days) to STZ-induced diabetic rats. The mangiferin treated diabetic rats significantly decreased the level of blood glucose, glycosylated hemoglobin as well as increased level of insulin and hemoglobin. The activities of hexokinase, pyruvate kinase, glucose-6-phosphate dehydrogenase, glycogen synthase, and glycogen content level were increased to near normal in mangiferin treated diabetic rats. The activities of lactate dehydrogenase, glucose-6-phosphatase, fructose-1,6-diphosphatase and glycogen phosphorylase were significantly decreased in liver tissue of diabetic treated rats. These findings demonstrated that mangiferin possess antidiabetic activity against STZ-induced diabetic rats. The antidiabetic effect of mangiferin was compared with standard antidiabetic drug glibenclamide.

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Section: Discussionmentioning

confidence: 99%

Antihyperglycemic Effect of Mangiferin in Streptozotocin Induced Diabetic Rats

Sellamuthu

Muniappan

Perumal

et al. 2009

JOURNAL OF HEALTH SCIENCE

100

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“…Mangiferin was widely distributed especially in the leaves and the bark in the Anacardiaceae and Gentianaceae families [21]. Mangiferin was one of the pharmacologically active compounds, which has been reported to have multiple biological effects and also antidiabetic effects [22][23][24]. Ethanolic extract of the leaves of M. indica L. leaves produced a significant hypoglycemic effect at a dose of 250 mg/kg, both in normal and streptozotocin (STZ)-induced diabetic animals.…”

Section: Resultsmentioning

confidence: 99%

Hypoglycemic Activity of Ten Medicinal Plants Extract in Glucose Induced Mice

Muhtadi

Irenka

Ayu

et al. 2017

Asian J Pharm Clin Res

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Objective: To evaluate and compare the hypoglycemic activity of 10 medicinal plants extract that is used empirically to treat hyperglycemia in Indonesia, to determine plant with the most potential as a hypoglycemic agent.Methods: Activity test was conducted in Swiss Webster glucose-induced mice with glucose tolerance test. The ethanolic extracts of Mangifera indica L. leaves, Persea americana Mill. leaves, Acorus calamus L. rhizome, Phyllanthus niruri L. herb, Syzygium cumini (L.) skeels bark, Zingiber officinale Roscoe rhizome, Moringa oleifera Lam. leaves, Tamarindus indica L. seed, Momordica charantia L. fruits, and Azadirachta indica A. juss leaves, which were given orally at the same dose of 300 mg/kg bw. The blood samples were used for determination of glucose level examination using a glucose meter and test strips (Accu-Chek). Results:The ethanolic extract of M. indica L. leaves has the best activity in reduction of blood glucose level in mice, followed by Z. officinale Roscoe rhizome, A. calamus L. rhizome, T. indica L. seed., M. charantia L. fruit., S. cumini (L.) skeels bark, P. niruri L. herb., P. americana Mill. leaves, and A. indica A. juss leaves. Conclusion:Results of this study suggest the potential use of M. indica L. leaves extract in the therapy of hyperglycemia.

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“…Mangiferin is an active constituent of these species, and demonstrates antidiabetic properties based on observed decreases of insulin resistance in non-insulin-dependent mice (Miura et al, 2001). As a result, mangiferin isolated from S. chinensis was evaluated in a series of genotoxicity studies to confirm the safety of its usage, and showed no mutagenicity up to 5 mg/plate when tested in S. typhimurium strains TA 97a, TA 98, TA 100, TA 102, and TA 1535, both with and without metabolic activation (Govindaraj et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Assessment of genotoxic, cytotoxic, and protective effects of Salacia crassifolia (Mart. Ex. Schult.) G. Don. stem bark fractions in mice

Carneiro

Silva²,

Menezes³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Salacia crassifolia (Mart. Ex. Schult.) G. Don., popularly known in Brazil as "bacupari", "cascudo", and "saputá", is a shrub of the Celastraceae family that is unique to the Brazilian Cerrado region. In folk medicine, this plant has been mainly used to treat skin cancer and gastric ulcers. In the present study, the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic effects of S. crassifolia stem bark fractions (hexane, ethyl acetate, and hydroalcoholic extracts) were evaluated using the mouse bone marrow micronucleus test. Our results showed that none of the S. crassifolia fractions led to a significant increase in the frequency of micronucleated polychromatic erythrocytes (MNPCE) (P > 0.05), suggesting the absence of genotoxicity. In the antigenotoxicity assessment, a significant decrease in the MNPCE frequency was observed in all fractions of this plant (P < 0.05), demonstrating its protective action against genotoxicity induced by mitomycin C (MMC), which was used as the positive control. Only the hexane fraction of S. crassifolia significantly decreased the poly-and normochromatic erythrocyte ratio (PCE/NCE) in all doses tested (P < 0.05), demonstrating its cytotoxic activity. In association with MMC, both ethyl acetate and hydroalcoholic fractions significantly increased the PCE/NCE ratio in almost all doses tested (P < 0.05), demonstrating the protective action of S. crassifolia against the cytotoxic effect of the positive control. In contrast, the hexane fraction presented a significant decrease in the PCE/NCE ratio in all treatments (P < 0.05), demonstrating an increase in this plant's cytotoxicity in mouse bone marrow cells.

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Antidiabetic activity of a xanthone compound, mangiferin

Cited by 172 publications

References 9 publications

Antihyperglycemic Effect of Mangiferin in Streptozotocin Induced Diabetic Rats

Antihyperglycemic Effect of Mangiferin in Streptozotocin Induced Diabetic Rats

Hypoglycemic Activity of Ten Medicinal Plants Extract in Glucose Induced Mice

Assessment of genotoxic, cytotoxic, and protective effects of Salacia crassifolia (Mart. Ex. Schult.) G. Don. stem bark fractions in mice

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