2009
DOI: 10.1016/j.homp.2009.02.004
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Antidepressants, suicidality and rebound effect: evidence of similitude?

Abstract: Rebound and withdrawal effects, including suicidality occur with antidepressant drugs. They are relatively rare but more intense than the primary action of the drug. The probability of such effects is influenced by patient factors including age and diagnosis, and drug factors including half-life.

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Cited by 29 publications
(35 citation statements)
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“…Since 1998, we have been scientifically grounding the principle of therapeutic similarity through the systematic study of the "rebound effect" of modern drugs ("paradoxical reaction" of the organism), [2][3][4][5][6][7][8][9][10][11][12] showing the manifestation of this secondary and opposite reaction of the organism after the primary action of numerous classes of drugs. At the end of 2013, we published a review on the rebound effect of drugs in this journal, 13 showing the extent of the phenomenon and alerting health professionals about the serious consequences that this unknown adverse event can cause.…”
Section: Introductionmentioning
confidence: 99%
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“…Since 1998, we have been scientifically grounding the principle of therapeutic similarity through the systematic study of the "rebound effect" of modern drugs ("paradoxical reaction" of the organism), [2][3][4][5][6][7][8][9][10][11][12] showing the manifestation of this secondary and opposite reaction of the organism after the primary action of numerous classes of drugs. At the end of 2013, we published a review on the rebound effect of drugs in this journal, 13 showing the extent of the phenomenon and alerting health professionals about the serious consequences that this unknown adverse event can cause.…”
Section: Introductionmentioning
confidence: 99%
“…the principle of siMilarity in the light of Modern pharMacology [2][3][4][5][6][7][8][9][10][11][12][13] Building a bridge between the principle of similarity and modern scientific rationality, hundreds of studies de-scribed, in recent medical literature, the occurrence of secondary and opposite reactions of the organism after the primary actions of different drugs, confirming the homeopathic postulate. As mentioned previously, this secondary action or organism's reaction, which manifests itself automatically and instinctively in order to maintain the homeostasis of the system, is described by contemporary pharmacology and physiology as the rebound effect of the drugs, or paradoxical reaction of the organism, respectively.…”
Section: Introductionmentioning
confidence: 99%
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“…Tanto o retorno a sintomas antigos quando a agravação de cura indicará um bom prognóstico, trazendo ao investigador o indício de que o medicamento esta sendo efetivo e que uma melhora evidente ocorrerá (Teixeira, 1997;Teixeira, 2009 (Sandstedt, Sorensen, 1995;Formaker et al,1998). Para outros autores, muitos pacientes com a síndrome afirmam que o aparecimento dos sintomas refere-se a estressores traumáticos (Van Der Ploeg et al,1987;Grushka ;Sessle,1991 Esse trabalho é o primeiro na literatura (salvo melhor juízo) a abordar a terapêutica homeopática para tratar a sintomatologia na Síndrome da ardência bucal.…”
Section: Discussionunclassified