Antidepressants, suicidality and rebound effect: evidence of similitude?

Abstract

Rebound and withdrawal effects, including suicidality occur with antidepressant drugs. They are relatively rare but more intense than the primary action of the drug. The probability of such effects is influenced by patient factors including age and diagnosis, and drug factors including half-life.

Therapeutic use of the rebound effect of modern drugs: "New homeopathic medicines"

“…Since 1998, we have been scientifically grounding the principle of therapeutic similarity through the systematic study of the "rebound effect" of modern drugs ("paradoxical reaction" of the organism), [2][3][4][5][6][7][8][9][10][11][12] showing the manifestation of this secondary and opposite reaction of the organism after the primary action of numerous classes of drugs. At the end of 2013, we published a review on the rebound effect of drugs in this journal, 13 showing the extent of the phenomenon and alerting health professionals about the serious consequences that this unknown adverse event can cause.…”

“…the principle of siMilarity in the light of Modern pharMacology [2][3][4][5][6][7][8][9][10][11][12][13] Building a bridge between the principle of similarity and modern scientific rationality, hundreds of studies de-scribed, in recent medical literature, the occurrence of secondary and opposite reactions of the organism after the primary actions of different drugs, confirming the homeopathic postulate. As mentioned previously, this secondary action or organism's reaction, which manifests itself automatically and instinctively in order to maintain the homeostasis of the system, is described by contemporary pharmacology and physiology as the rebound effect of the drugs, or paradoxical reaction of the organism, respectively.…”

“…Epidemiological studies show that this magnitude can cause severe and fatal events after the suspension of certain classes of drugs (antithrombotics, antidepressants, bronchodilators, anti-dyspeptics and immunomodulators, among others). [4][5][6][7][8][9][10][11][12][13] The rebound effect manifests itself at different intervals (hours to weeks) after the exhaustion of the biological effect (half-life) of the drug, and its duration is also variable. Despite the suspension or discontinuation of the drug being a prerequisite for the manifestation of the rebound effect, given that the primary action of the drug persists while the receptors are being stimulated (biological half-life), studies show that the rebound effect may also occur in the course of treatment due to therapeutic failure or the development of tolerance, tachyphylaxis or desensitization.…”

“…On the other hand, a slow and gradual reduction of doses (tapering) to prevent abrupt discontinuation can minimize the occurrence of the rebound effect. [2][3][4][5][6][7][8][9][10][11][12][13] In analogy to the proposal to be detailed below, reports in the literature describe the use of conventional drugs according to therapeutic similarity. Among these, we can cite the use of biphasic oral contraceptives to promote ovulation and rebound pregnancy in women with functional sterility and the use of central nervous system stimulants (methylphenidate) to treat attention deficit hyperactivity disorder (ADHD).…”

Ação do tratamento homeopático na sintomatologia da síndrome da ardência bucal em duas fases: estudo duplo cego placebo controlado e estudo aberto

“…Tanto o retorno a sintomas antigos quando a agravação de cura indicará um bom prognóstico, trazendo ao investigador o indício de que o medicamento esta sendo efetivo e que uma melhora evidente ocorrerá (Teixeira, 1997;Teixeira, 2009 (Sandstedt, Sorensen, 1995;Formaker et al,1998). Para outros autores, muitos pacientes com a síndrome afirmam que o aparecimento dos sintomas refere-se a estressores traumáticos (Van Der Ploeg et al,1987;Grushka ;Sessle,1991 Esse trabalho é o primeiro na literatura (salvo melhor juízo) a abordar a terapêutica homeopática para tratar a sintomatologia na Síndrome da ardência bucal.…”