Antidepressants given repeatedly increase the behavioural effect of dopamine D-2 agonist

J, Maj; Rogóż, Z; Skuza, G; Sowińska, H

doi:10.1007/bf01247108

Cited by 32 publications

(5 citation statements)

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“…A similar increase in the effect of D-amphetamine and PRA, i.e. an enhanced response of dopamine D2 receptors, was observed after different antidepressants ), which we regarded as a result of increased affinity of those receptors for their agonists (Klimek and Maj, 1989;Maj, 1984Maj, , 1986Maj et al, 1989Maj et al, , 1996. Hence repeated PRA probably behaves likewise.…”

Section: Discussionsupporting

confidence: 60%

“…Besides, we administered PRA repeatedly and examined its effect on the locomotor hyperactivity induced by D-amphetamine or quinpirole. Our earlier findings showed that repeated administration of antidepressants with different pharmacological profiles enhanced the action of D-amphetamine, quinpirole and other dopamine stimulants (Maj, 1984(Maj, , 1986Maj et al, 1989). Similar effects were reported for a few antidepressants by other authors (Spyraki and Fibiger, 1981;Serra et al, 1979).…”

Section: Pramipexolesupporting

confidence: 67%

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Antidepressant effects of pramipexole, a novel dopamine receptor agonist

Rogóż

Skuza

et al. 1997

J. Neural Transmission

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Pramipexole (2-amino-4,5,6,7-tetrahydro-6-propyl-amino-benzthiazole-dihydrochl oride), a new dopamine receptor agonist with preference for D3 compared to D2 and D4 receptors, was tested in rats in respect of its potential antidepressant activity. In the forced swimming test the drug under study, given three times in rats, reduced the immobility time. In the forced swimming test, joint treatment with antidepressants (imipramine, amitriptyline) and pramipexole evoked a more potent effect than any of the drugs given alone; however, the locomotor hyperactivity was weaker after joint administration. Citalopram and fluoxetine, inactive per se in the forced swimming tests, visibly enhanced the antidepressant-like effect of pramipexole but, on the other hand, they attenuated the locomotor hyperactivity evoked by the drug. Repeated treatment with pramipexole (0.3 or 1 mg/kg, twice daily for 14 days) increased the locomotor activity measured at 1 h after the last dose. Repeated administration of pramipexole (as above) potentiated the D-amphetamine- or quinpirole-induced locomotor hyperactivity. The obtained results indicate that, in the tests used, pramipexole evokes effects similar to those of typical antidepressants and, at the same time, enhances their activity (the forced swimming test in rats); therefore it may be regarded as a potential antidepressant drug.

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Section: Discussionsupporting

confidence: 60%

Section: Pramipexolesupporting

confidence: 67%

Antidepressant effects of pramipexole, a novel dopamine receptor agonist

Rogóż

Skuza

et al. 1997

J. Neural Transmission

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“…Repeated administrations of antidepressant drugs have been found to potentiate the locomotor stimulant effects of dopamine D 2 /D 3 agonists. These effects were apparent following systemic administration ; Maj and Wędzony 1988;Maj et al 1984Maj et al , 1989Martin-Iverson et al 1983;Płaźnik and Kostowski 1987;Willner and Montgomery 1981) or direct injection of D 2 /D 3 agonists into the nucleus accumbens Wędzony 1985,1988;Maj et al 1987). It is noteworthy that stereotypy, a behavioral effect induced by D-amphetamine and apomorphine, was not increased by repeated treatment of antidepressant drugs (Delini-Stula and Vassout 1979;Serra et al 1990;Spyraki and Fibiger 1981).…”

Section: Introductionmentioning

confidence: 90%

Effects of antidepressant drugs on the dopamine D2/D3 receptors in the rat brain differentiated by agonist and antagonist binding – an autoradiographic analysis

Rogoż

Dziedzicka-Wasylewska

1999

Naunyn-Schmiedeberg's Arch Pharmacol

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In the present study the effect of antidepressant drugs on the density of dopamine D2/D3 receptors in the rat forebrain was examined using autoradiography, since this technique provides the appropriate anatomical resolution. Male Wistar rats were treated with three various antidepressant drugs: imipramine, citalopram and mianserin in a dose of 10 mg/kg p.o., acutely (single dose) or repeatedly (twice a day for 14 days). To estimate the distribution of D2/D3 receptors, we chose following radioligands: [3H]raclopride, a non-selective antagonist of D2/D3 receptors, and [3H]quinpirole, a non-selective D2/D3 agonist. When [3H]raclopride was used as a radioligand, no significant differences in the density of D2/D3 receptors were observed after administration of the investigated drugs. However, following repeated administration of imipramine, citalopram and mianserin, a significant increase in the binding of [3H]quinpirole was observed, both in the nucleus caudatus and nucleus accumbens septi. In some cases the increase of [3H]quinpirole binding was also observed after acute treatment with antidepressant drugs. Thus, using an agonist as a radioligand, we were able to see upregulation of dopamine D2/D3 receptors in the rat forebrain following administration of antidepressant drugs, which might be interpreted as the biochemical correlative for the postsynaptic dopamine D2/D3 receptor supersensitivity observed in previous behavioral studies.

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“…There is accumulating evidence suggesting that the administration of selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, citalopram, and paroxetine, alters the biochemical and behavioral responses to dopaminergic agents, as well as the basal activity of dopaminergic neurons. For example, the repeated administration of various SSRI appears to augment the behavioral response to dopamine (DA) receptor agonists such as quinpirole (Ainsworth et al, 1998;Collu et al, 1996Collu et al, , 1997Maj et al, 1989;Serra et al, 1992). A number of studies using various animal models of depression suggest that DA may play an important role in the antidepressant action of SSRI (Bonhomme and Esposito, 1998;D'Aquila et al, 1997;Renard et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Acute and repeated administration of fluoxetine, citalopram, and paroxetine significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study

Sekine

Suzuki

Ramachandran

et al. 2006

Synapse

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We examined the effect of the administration of the selective serotonin reuptake inhibitors (SSRIs) fluoxetine, citalopram, and paroxetine on the activity of spontaneously active dopamine (DA) neurons in the substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) in anesthetized adult male Sprague-Dawley rats. This was accomplished using the technique of in vivo extracellular recording. A single injection of 2.5 mg/kg (i.p.) of fluoxetine significantly increased the number of spontaneously active SNC and VTA DA neurons. In contrast, a single injection of either 1 mg/kg (i.p.) of paroxetine or 5 mg/kg of fluoxetine significantly increased the number of spontaneously active VTA DA neurons. The repeated administration (one injection per day for 21 days) of all of the SSRIs produced a significant increase in the number of spontaneously active VTA DA neurons. Overall, our results indicate that the systemic administration of SSRI alters the activity of midbrain DA neurons with differential effects on VTA compared with SNC DA neurons.

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Antidepressants given repeatedly increase the behavioural effect of dopamine D-2 agonist

Cited by 32 publications

References 32 publications

Antidepressant effects of pramipexole, a novel dopamine receptor agonist

Antidepressant effects of pramipexole, a novel dopamine receptor agonist

Effects of antidepressant drugs on the dopamine D2/D3 receptors in the rat brain differentiated by agonist and antagonist binding – an autoradiographic analysis

Acute and repeated administration of fluoxetine, citalopram, and paroxetine significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study

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