Antidepressants for Depression in Patients with Dementia: A Review of the Literature

Leong, Christine

doi:10.4140/tcp.n.2014.254

Cited by 50 publications

(34 citation statements)

References 26 publications

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“…In particular, given the limited efficacy and high rate of adverse effects of psychotropic medication [45,46], as well as the burden of neuropsychiatric symptoms [47], the current program could be considered as an add-on therapy in a community setting.…”

Section: Discussionmentioning

confidence: 99%

Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer’s Disease: A Randomized Controlled Trial

Hoffmann

Sobol

Frederiksen

et al. 2016

JAD

233

260

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Abstract.Background: Studies of physical exercise in patients with Alzheimer's disease (AD) are few and results have been inconsistent. Objective: To assess the effects of a moderate-to-high intensity aerobic exercise program in patients with mild AD. Methods: In a randomized controlled trial, we recruited 200 patients with mild AD to a supervised exercise group (60-min sessions three times a week for 16 weeks) or to a control group. Primary outcome was changed from baseline in cognitive performance estimated by Symbol Digit Modalities Test (SDMT) in the intention-to-treat (ITT) group. Secondary outcomes included changes in quality of life, ability to perform activities of daily living, and in neuropsychiatric and depressive symptoms. Results: The ITT analysis showed no significant differences between intervention and control groups in change from baseline of SDMT, other cognitive tests, quality of life, or activities of daily living. The change from baseline in Neuropsychiatric Inventory differed significantly in favor of the intervention group (mean: -3.5, 95% confidence interval (CI) -5.8 to -1.3, p = 0.002). In subjects who adhered to the protocol, we found a significant effect on change from baseline in SDMT as compared with the control group (mean: 4.2, 95% CI 0.5 to 7.9, p = 0.028), suggesting a dose-response relationship between exercise and cognition. * Correspondence to: Professor, DMSc, MD, Steen G. K. Hoffmann et al. / Aerobic exercise in Alzheimer's diseaseConclusions: This is the first randomized controlled trial with supervised moderate-to-high intensity exercise in patients with mild AD. Exercise reduced neuropsychiatric symptoms in patients with mild AD, with possible additional benefits of preserved cognition in a subgroup of patients exercising with high attendance and intensity.

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Section: Discussionmentioning

confidence: 99%

Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer’s Disease: A Randomized Controlled Trial

Hoffmann

Sobol

Frederiksen

et al. 2016

JAD

233

260

View full text Add to dashboard Cite

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“…In addition, psychological treatments can reduce depressive symptoms in people with dementia [45]. & A recent review of ten randomized controlled trials and three meta-analyses that examined the evidence for efficacy and safety of anti-depressants in treating depression in dementia was inconclusive [46]. & In addition, selective serotonin reuptake inhibitors (SSRIs) have been associated with increased falls in nursing home patients.…”

Section: Anxiety/depression/irritabilitymentioning

confidence: 99%

“…& In addition, selective serotonin reuptake inhibitors (SSRIs) have been associated with increased falls in nursing home patients. Treatment recommendations are to treat significant persistent depressed mood with an SSRI based on minimal anti-cholinergic activity [46]. …”

Section: Anxiety/depression/irritabilitymentioning

confidence: 99%

Treatment and Management of Dementia Due to Alzheimer’s Disease

Molano

Bratt

Shatz

2015

Curr Treat Options Neurol

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Alzheimer's disease (AD) is a progressive neurological disorder typically associated with episodic memory loss as the initial symptom, but individuals <65 years old may present with executive dysfunction, word finding difficulties, or visual processing deficits. In those with AD, curative treatments are not available, but there are interventions which may modify disease course, symptom appearance and severity, enhance quality of life for patient and caregivers, and maintain safety. Both pharmacological and non-pharmacological interventions are important.

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“…In cases of severe depression, or depression not managed through nonpharmacologic approaches, a trial of an antidepressant may be initiated. 13 Selective serotonin reuptake inhibitors are often used as a first-line pharmacologic treatment because of their favorable side effect profile and because antidepressants with strong anticholinergic effects may worsen cognition. Antidepressants may also be used to treat agitation and psychosis in people with dementia.…”

Section: Antidepressantsmentioning

confidence: 99%

Neuropsychiatric Management of Young-Onset Dementias

Shinagawa

2015

Psychiatric Clinics of North America

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Antidepressants for Depression in Patients with Dementia: A Review of the Literature

Cited by 50 publications

References 26 publications

Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer’s Disease: A Randomized Controlled Trial

Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer’s Disease: A Randomized Controlled Trial

Treatment and Management of Dementia Due to Alzheimer’s Disease

Neuropsychiatric Management of Young-Onset Dementias

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