Antidepressants Fluoxetine Mediates Endoplasmic Reticulum Stress and Autophagy of Non-Small Cell Lung Cancer Cells Through ATF4-AKT-mTOR Signaling Pathway.
Abstract:Cancer patients often suffer the depression with worse quality of life and prognosis. Therefore, studying how antidepressants affect the cancer is of great significance. Recent years witnessed the reports that antidepressants have the antiproliferation effect, However, in lung cancer it’s still unclear about the specific molecular target. This study mainly focused on how fluoxetine influenced different types of cells and discovered the molecular basis of its inhibitory effect in lung cancer. The specific antip… Show more
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