Antidepressants as emerging contaminants: Occurrence in wastewater treatment plants and surface waters in Hangzhou, China

Chen, Yuan; Wang, Junlin; Xu, Pingwei; Xiang, Jie; Xu, Di; Peng, Cheng; Wu, Lizhi; Zhang, Nianhua; Chen, Zhijian

doi:10.3389/fpubh.2022.963257

Cited by 8 publications

(3 citation statements)

References 32 publications

(26 reference statements)

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“…In recent years, drugs designed to treat anxiety and depression have been detected in surface waters globally. In particular, selective serotonin reuptake inhibitors (SSRIs), including sertraline, fluoxetine, and citalopram are commonly reported (Chen et al, 2022; Rzymski et al, 2017; Vaclavik et al, 2020). The SSRIs act by blocking serotonin, norepinephrine, and dopamine transporters systems.…”

Section: Introductionmentioning

confidence: 99%

Personality Affects Zebrafish Response to Sertraline

Al Shuraiqi,

Abed,

Al‐Habsi

et al. 2023

Enviro Toxic and Chemistry

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Sertraline is widely prescribed to treat anxiety and depression. Sertraline acts by blocking serotonin, norepinephrine, and dopamine transporters systems and has been detected in surface waters globally where it may impact fish behavior. We classified zebrafish personality on three behavioral axes: boldness, anxiety and sociability, assigning fish as either high or low in each category. The fish were exposed to nominal concentrations of 0, 5, 50, 500, or 5000 ng/L sertraline (measured concentrations: <10, 21.3, 370 and 2200 ng/L respectively) to assess changes in boldness, anxiety and sociability after seven and 28 days. We also measured shoaling behavior and response to an alarm cue, and determined the gut microbiome of a subset of fish. After seven days there was no overall effect of sertraline on boldness, but there was an interaction between initial personality and sex, with a stronger impact on females classified as low‐boldness personality. Sertraline reduced sociability in all treatments compared with the control, but there was again an interaction between sertraline and initial personality. Fish that were classified as low‐sociability responded more strongly to sertraline. After seven days, fish exposed to a nominal concentration of 5000 ng/L (2200 ng/L measured) showed higher anxiety than controls with the overall pattern of initial behavior retained. After 28 days, similar patterns were observed, but with higher variation. There was only a weak association between the gut microbiome and personality. Overall, the study highlights the importance of considering initial behavior and that it can affect response to pollutants. Our results may also be applicable to human studies and provide a mechanism to explain why different individuals respond differently to the drug.

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Section: Introductionmentioning

confidence: 99%

Personality Affects Zebrafish Response to Sertraline

Al Shuraiqi,

Abed,

Al‐Habsi

et al. 2023

Enviro Toxic and Chemistry

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“…These pollutants are transferred mainly to the aquatic environment through effluents from wastewater plants and hospitals [2]. The presence of antidepressant pharmaceuticals in wastewater has received particular attention among the various classes of emerging contaminants due to their widespread use, heavy consumption, and toxicological effects [3,4]. These compounds can help relieve symptoms of depression, anxiety disorders, seasonal affective disorder, and dysthymia.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Photocatalytic Degradation of the Antidepressant Sertraline in Aqueous Solutions by Zinc Oxide Nanoparticles

Mohamed

Riyad

Hendawy

et al. 2023

Water

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Antidepressants are one of the main pollutants in the aquatic environment. They are being widely studied due to their widespread use, possible health effects, and partial removal from wastewater treatment plants by conventional methods. Photocatalysis is an effective and ecologically beneficial method in wastewater treatment. In the present study, the photocatalytic degradation of sertraline hydrochloride (SERT) in water using nano-sized zinc oxide (ZnO-NPs) was investigated. The ZnO-NPs were synthesized from zinc gluconate as a precursor by the sol–gel method. The crystal structure, morphology, surface charge, and textural properties were characterized by X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray analyses, transmission electron microscopy, Fourier-transform infrared spectroscopy, zeta potential, and N2 adsorption–desorption measurements. The removal of SERT in water was explored by different processes: H2O2/UV, ZnO-NPs/H2O2/UV, and ZnO-NPs/UV. Our results indicate that the combination of both UV illumination and the ZnO-NP as a catalyst was necessary for the efficient degradation of the drug. Nearly complete removal of SERT (98.7%) was achieved in 30 min with the ZnO-NPs/UV process at room temperature. The photodegradation of SERT follows first-order kinetics with a rate constant of 0.0678 min−1. The results reveal that SERT degradation with ZnO-NPs/UV is pH-dependent, as the maximum drug removal was achieved at pH 11. Initial drug concentration, catalyst dose, and hydrogen peroxide concentration were also crucial in the removal of SERT. Our findings indicate that the high specific surface area and porous structure of ZnO-NP enhance its photocatalytic performance toward photodegradation of SERT, i.e., ZnO-NP is an efficient nanophotocatalyst for the degradation of SERT under UV irradiation.

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“…Global average fluoxetine (selective serotonin reuptake inhibitor) concentration in surface waters is 0.012-1.4 μg/L (Weinberger & Klaper, 2014), while its concentration in wastewater treatment plant effluents were found to reach 3.5 µg/L (Salgado et al, 2011). Observed concentrations of venlafaxine (a selective serotonin-norepinephrine reuptake inhibitor) in surface waters are variable ranging from 0.021 µg/L-0.64 µg/L (Chen et al, 2022;de Jongh et al, 2012;Fernandes et al, 2020) with concentrations as high as 2.190 µg/L found in wastewater treatment plant effluent (Schultz & Furlong, 2008).…”

Section: Degradation Of Diclofenac During the Experimentsmentioning

confidence: 99%

The hidden impact: exploring sublethal effects of pharmaceutical disruption on aquatic ecosystem functioning

Vasantha Raman

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Pharmaceuticals are increasingly released into surface waters and therefore ubiquitous in aquatic systems. While pharmaceuticals are known to influence species interactions, their effect on host-parasite interactions is still underexplored despite potential ecosystem-level consequences. Here, we ask whether diclofenac, a widely used non-steroid anti-inflammatory drug, affects the interaction between a phytoplankton host (Staurastrum sp.; green alga) and its obligate fungal parasite (Staurastromyces oculus; chytrid). We hypothesized that the effect of increasing diclofenac concentration on overall microbial system, including bacteria, host, and where applicable parasites, depends on parasite exposure, and that parasite is more sensitive to increasing diclofenac concentrations than the host. We assessed acute and chronic effects of a wide range of diclofenac concentrations (0-150 mg/L) on

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Antidepressants as emerging contaminants: Occurrence in wastewater treatment plants and surface waters in Hangzhou, China

Cited by 8 publications

References 32 publications

Personality Affects Zebrafish Response to Sertraline

Personality Affects Zebrafish Response to Sertraline

Enhanced Photocatalytic Degradation of the Antidepressant Sertraline in Aqueous Solutions by Zinc Oxide Nanoparticles

The hidden impact: exploring sublethal effects of pharmaceutical disruption on aquatic ecosystem functioning

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