Antidepressants and Their Impact on Sleep

Dhuna, Nikhil A.; Malkani, Roneil G.

doi:10.1007/s40675-020-00189-5

Cited by 3 publications

(2 citation statements)

References 57 publications

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“…Specific cases of drug-induced sleep EEG effects are benzodiazepines and benzodiazepine receptor agonists, also known as positive allosteric modulators of GABA A receptors, which are known for their suppressive effects on low-and facilitating effects on high-frequency EEG activities in all behavioral states, with the additional increase of spindle frequency activity in nonrapid eye movement (NREM) sleep [15][16][17]. A further widely reported medication effect on sleep is the rapid eye movement sleep (REM)-suppressive effect of several classes of antidepressive pharmacological agents, including selective serotonin reuptake inhibitors (SSRI), selective noradrenalin reuptake inhibitors (SNRI), tricyclic antidepressants (TCA) and monoamine oxidase inhibitor (MAOI) drugs [18,19]. In addition, several non-psychotropic medications were reported to cause sleep disturbances [20,21].…”

Section: Introductionmentioning

confidence: 99%

Sleep alterations as a function of 88 health indicators

Ujma,

Bódizs

2024

BMC Med

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Background Alterations in sleep have been described in multiple health conditions and as a function of several medication effects. However, evidence generally stems from small univariate studies. Here, we apply a large-sample, data-driven approach to investigate patterns between in sleep macrostructure, quantitative sleep EEG, and health. Methods We use data from the MrOS Sleep Study, containing polysomnography and health data from a large sample (N = 3086) of elderly American men to establish associations between sleep macrostructure, the spectral composition of the electroencephalogram, 38 medical disorders, 2 health behaviors, and the use of 48 medications. Results Of sleep macrostructure variables, increased REM latency and reduced REM duration were the most common findings across health indicators, along with increased sleep latency and reduced sleep efficiency. We found that the majority of health indicators were not associated with objective EEG power spectral density (PSD) alterations. Associations with the rest were highly stereotypical, with two principal components accounting for 85–95% of the PSD-health association. PC1 consists of a decrease of slow and an increase of fast PSD components, mainly in NREM. This pattern was most strongly associated with depression/SSRI medication use and age-related disorders. PC2 consists of changes in mid-frequency activity. Increased mid-frequency activity was associated with benzodiazepine use, while decreases were associated with cardiovascular problems and associated medications, in line with a recently proposed hypothesis of immune-mediated circadian demodulation in these disorders. Specific increases in sleep spindle frequency activity were associated with taking benzodiazepines and zolpidem. Sensitivity analyses supported the presence of both disorder and medication effects. Conclusions Sleep alterations are present in various health conditions.

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Section: Introductionmentioning

confidence: 99%

Sleep alterations as a function of 88 health indicators

Ujma,

Bódizs

2024

BMC Med

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“…Specific cases of drug-induced sleep EEG effects are benzodiazepines and benzodiazepine receptor agonists, also known as positive allosteric modulators of GABAA receptors, which are known for their suppressive effects on low-and facilitating effects on high-frequency EEG activities in all behavioral states, with the additional increase of spindle frequency activity in NREM sleep [15][16][17]. A further widely reported medication effect on sleep is the REM-suppressive effect of several classes of antidepressive pharmacological agents, including selective serotonin reuptake inhibitors (SSRI), selective noradrenalin reuptake inhibitors (SNRI), tryciclic antidepressants (TCA) and monoamine oxidase inhibitor (MAOI) drugs [18,19]. In addition, several non-psychotropic medications were reported to cause sleep disturbances [20,21].…”

Section: Introductionmentioning

confidence: 99%

Sleep alterations as a function of 88 health indicators

Ujma,

Bódizs

2023

Preprint

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Alterations in sleep have been described in multiple health conditions and as a function of several medication effects. However, evidence generally stems from small univariate studies. Here, we apply a large-sample, data-driven approach to investigate patterns between changes in sleep macrostructure, quantitative sleep EEG and health. We use data from the MrOS Sleep Study, containing polysomnography and health data from a large sample (N=3086) of elderly American men to establish associations between sleep macrostructure, the spectral composition of the electroencephalogram, 38 medical disorders, 2 health behaviors and the use of 48 medications. Of sleep macrostructure variables, increased REM latency and reduced REM duration was the most common finding across health indicators, along with increased sleep latency and reduced sleep efficiency. We found that the majority of health indicators were not associated with objective EEG PSD alterations. Associations with the rest were highly stereotypical, with two principal components accounting for 85-95% of the PSD-health association. PC1 consists of a decrease of slow and an increase of fast PSD components, mainly in NREM. This pattern was most strongly associated with depression/SSRI medication use and age-related disorders. PC2 consists of changes in mid-frequency activity. Increased mid-frequency activity was associated with benzodiazepine use, while decreases are associated with cardiovascular problems and associated medications, in line with immune-mediated circadian demodulation in these disorders. Specific increases in sleep spindle frequency activity were associated with taking benzodiazepines and zolpidem. Sensitivity analyses supported the presence of both disorder and medication effects.

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Antidepressants and sleep

Holshoe

2023

Encyclopedia of Sleep and Circadian Rhythms

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Antidepressants and Their Impact on Sleep

Cited by 3 publications

References 57 publications

Sleep alterations as a function of 88 health indicators

Sleep alterations as a function of 88 health indicators

Sleep alterations as a function of 88 health indicators

Antidepressants and sleep

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