Antidepressants and menstruation disorders in women: a cross-sectional study in three centers

Uğuz, Faruk; Sahingoz, Mine; Köse, Seyit Ali; Ozbebit, Ozgur; Şengül, Cem; Selvı, Yavuz; Ayhan, Medine Gıynaş; Dagistanli, Adnan; Askin, Rustem

doi:10.1016/j.genhosppsych.2012.03.014

Cited by 17 publications

(13 citation statements)

References 21 publications

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“…Cocaine use has been associated with shifts in bacterial phyla in the gut 92 and additionally has been associated with a greater likelihood of contracting sexually transmitted infections 93 , 94 . The use of antidepressants has been linked to menstrual disorders and hormonal changes in women 95 , 96 both of which may cause indirect shifts in the vaginal microbiota. As these studies may suggest a potential impact of drugs and medications and their byproducts on the vaginal microbiota, further exploration is needed to make any conclusions.…”

Section: Discussionmentioning

confidence: 99%

Cigarette smoking is associated with an altered vaginal tract metabolomic profile

Nelson

Borgogna

Michalek

et al. 2018

Sci Rep

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Cigarette smoking has been associated with both the diagnosis of bacterial vaginosis (BV) and a vaginal microbiota lacking protective Lactobacillus spp. As the mechanism linking smoking with vaginal microbiota and BV is unclear, we sought to compare the vaginal metabolomes of smokers and non-smokers (17 smokers/19 non-smokers). Metabolomic profiles were determined by gas and liquid chromatography mass spectrometry in a cross-sectional study. Analysis of the 16S rRNA gene populations revealed samples clustered into three community state types (CSTs) ---- CST-I (L. crispatus-dominated), CST-III (L. iners-dominated) or CST-IV (low-Lactobacillus). We identified 607 metabolites, including 12 that differed significantly (q-value < 0.05) between smokers and non-smokers. Nicotine, and the breakdown metabolites cotinine and hydroxycotinine were substantially higher in smokers, as expected. Among women categorized to CST-IV, biogenic amines, including agmatine, cadaverine, putrescine, tryptamine and tyramine were substantially higher in smokers, while dipeptides were lower in smokers. These biogenic amines are known to affect the virulence of infective pathogens and contribute to vaginal malodor. Our data suggest that cigarette smoking is associated with differences in important vaginal metabolites, and women who smoke, and particularly women who are also depauperate for Lactobacillus spp., may have increased susceptibilities to urogenital infections and increased malodor.

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Section: Discussionmentioning

confidence: 99%

Cigarette smoking is associated with an altered vaginal tract metabolomic profile

Nelson

Borgogna

Michalek

et al. 2018

Sci Rep

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“…In a cross-sectional study conducted by Uguz et. al., it was found that the incidence of menstruation disorders in a group of 1432 women taking antidepressants was 14.5% [ 9 ]. It is hypothesized that symptoms of bleeding are related to the minor, yet essential, role that serotonin has during hemostasis.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Uterine Bleed in a Postmenopausal Woman With the Use of Escitalopram

Yadav¹,

Bharat²,

Montrose³

2022

Cureus

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Selective serotonin reuptake inhibitors (SSRIs) are among the most widely used antidepressants worldwide. They are an effective first-line treatment for depression. Common side effects can be quickly remediated by switching to a different drug, making it easy to miss rare side effects and even causing them to go underreported. This case study examines an instance of uterine bleeding in a postmenopausal woman after starting an antidepressant. A detailed history determined that the medication was the only noticeable change in her daily routine before the onset of bleeding, making it the likely cause. Due to the high index of suspicion, the medication was discontinued, and it was apparent that the bleeding ceased. This phenomenon demonstrated the role of serotonin in potentiating the coagulation cascade. Research on this topic is limited, but there have been other reported cases of similar findings in the past.

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“…Antidepressants cause menstrual irregularities in the form of excessive bleeding and bleeding irregularities by disrupting the adhesion of platelets to collagen. [7][8][9] However, amenorrhea due to serotonergic antidepressants occurring independently of this mechanism is very rare. In the literature, there are case reports of amenorrhea associated with sertraline, escitalopram, fluoxetine, paroxetine, fluvoxamine, and duloxetine.…”

Section: Discussionmentioning

confidence: 99%

Vortioxetine-Induced Amenorrhea: A Case Report

et al. 2022

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Background: Vortioxetine is a novel multimodal antidepressant for the treatment of major depressive disorders and is widely used in clinical practice. Vortioxetine has a safe profile. However, there are case reports of other adverse effects in the literature. In this article, a case of amenorrhea due to vortioxetine is presented. Case:The patient is 36 years old, married, female, and is an anesthesiologist. She applied to the psychiatric outpatient clinic with symptoms of major depression. Vortioxetine was initiated at 10 mg/d and then gradually increased to 20 mg/d. She had regular menstruation until now. However, she did not menstruate after taking vortioxetine. The patient used vortioxetine for 3 months and never had a period. Pregnancy test and other tests to investigate organic etiology were normal. Two weeks after discontinuation of vortioxetine, the patient had a menstrual period.Conclusions: Further research is needed on the relationship and possible mechanisms between vortioxetine and amenorrhea.

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Antidepressants and menstruation disorders in women: a cross-sectional study in three centers

Cited by 17 publications

References 21 publications

Cigarette smoking is associated with an altered vaginal tract metabolomic profile

Cigarette smoking is associated with an altered vaginal tract metabolomic profile

Abnormal Uterine Bleed in a Postmenopausal Woman With the Use of Escitalopram

Vortioxetine-Induced Amenorrhea: A Case Report

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