Antidepressant Use in Pregnancy and the Risk of Attention Deficit with or without Hyperactivity Disorder in Children

Boukhris, Takoua; Sheehy, Odile; Bérard, Anick

doi:10.1111/ppe.12378

Cited by 29 publications

(33 citation statements)

References 28 publications

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“…Of these, 23 citations were retrieved for full‐text review. After full‐text screening, six cohort studies, four conducted in Europe, one in Canada, and one in China, met our inclusion criteria. All of the studies investigated prenatal antidepressant exposure; however, Sunjuan et al assessed antidepressant exposure during the first trimester only.…”

Section: Resultsmentioning

confidence: 99%

Antidepressant use during pregnancy and the risk of attention‐deficit/hyperactivity disorder in the children: a meta‐analysis of cohort studies

et al. 2018

BJOG

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Section: Resultsmentioning

confidence: 99%

Antidepressant use during pregnancy and the risk of attention‐deficit/hyperactivity disorder in the children: a meta‐analysis of cohort studies

et al. 2018

BJOG

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“…The use of psychopharmacological drugs during pregnancy has been subject to considerable controversy for the last decade. While there is reasonably consensus that antidepressants (ADs), specifically selective serotonin re‐uptake inhibitors (SSRIs), are unlikely to pose a substantial risk to the unborn child , controversy remains on certain specific issues, not least the hypothesized impact on childhood neurodevelopment . For antipsychotic drugs (APs), the amount of data is less impressive, and the amount of safety data available has been lagging the transition from usage patterns from first‐generation antipsychotics (FGAPs) to second‐generation antipsychotics (SGAPs) .…”

Section: Introductionmentioning

confidence: 99%

Patterns and predictors for prescription of psychotropics and mood‐stabilizing antiepileptics during pregnancy in Denmark 2000–2016

Damkier

Christensen

Broe

2018

Brit J Clinical Pharma

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“…[10][11][12][13] Furthermore, studies have also shown that pregnant women who use antidepressants to treat depression are at increased risk of adverse neonatal and childhood outcomes. 7,[10][11][12][14][15][16][17][18][19] Although progress in the utilisation of appropriate study designs and analytical approaches is being made to examine the association between antidepressant use during pregnancy and adverse perinatal outcomes, more research is needed to enhance our understanding about the association. To illustrate, previous studies that examined the risk of adverse perinatal outcomes associated with antidepressant use have not always taken into consideration the effect of the underlying condition itself, that is, depression.…”

Section: Backg Rou N Dmentioning

confidence: 99%

Risk of adverse perinatal outcomes among women with pharmacologically treated and untreated depression during pregnancy: A retrospective cohort study

Adhikari

Patten

Lee

et al. 2019

Paediatric Perinatal Epid

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Background The association between antidepressant use during pregnancy and adverse perinatal outcomes is unclear. The association without taking into consideration the independent effect of depression leads to a confounding of the effects of antidepressants with those of the underlying reason for the use of those medications. Additionally, a history of depression and antidepressant use may also influence this association. Objective This study examined the risks of adverse perinatal outcomes associated with antidepressant use during pregnancy. Methods This retrospective cohort study used population‐based data in Alberta, Canada, for women who delivered between 2012 and 2015 (n = 158486). Women with depression were identified using a validated case definition, and the receipt of antidepressants was identified using Anatomical Therapeutic Chemical codes. Adverse perinatal outcomes such as severe maternal/neonatal morbidity, preterm birth, and neonatal intensive care unit admission were assessed. Multivariable log‐binomial regression was used to estimate the risk of adverse perinatal outcomes associated with antidepressants, adjusting for age and parity. Results In total, 9.1% women had depression and 2.5% women received antidepressants during pregnancy. The relative risk of severe neonatal morbidity/mortality was 1.25 (95% confidence interval 1.17, 1.33) times higher for women with depression alone compared to women without depression. The risk of severe neonatal morbidity/mortality was 1.51 (95% confidence interval 1.36, 1.66) times higher for women who used antidepressants compared to women with depression alone—however, the risk differed between the women with and without a history of antidepressant use. A similar risk pattern was observed for preterm birth and neonatal intensive care unit admission. Conclusions Both depression and antidepressant use were independently associated with the risk of adverse perinatal outcomes; however, the risk associated with antidepressants was higher over and above the risk associated with depression. This may reflect the biological effects of antidepressants, greater severity of depression in those treated, or both.

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Antidepressant Use in Pregnancy and the Risk of Attention Deficit with or without Hyperactivity Disorder in Children

Cited by 29 publications

References 28 publications

Antidepressant use during pregnancy and the risk of attention‐deficit/hyperactivity disorder in the children: a meta‐analysis of cohort studies

Antidepressant use during pregnancy and the risk of attention‐deficit/hyperactivity disorder in the children: a meta‐analysis of cohort studies

Patterns and predictors for prescription of psychotropics and mood‐stabilizing antiepileptics during pregnancy in Denmark 2000–2016

Risk of adverse perinatal outcomes among women with pharmacologically treated and untreated depression during pregnancy: A retrospective cohort study

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