Antidepressant use and risk for mortality in 121,252 heart failure patients with or without a diagnosis of clinical depression

Brouwers, Corline; Christensen, Stefan; Damen, Nikki L.; Denollet, Johan; Torp‐Pedersen, Christian; Gislason, Gunnar; Pedersen, Susanne

doi:10.1016/j.ijcard.2015.11.032

Cited by 49 publications

(29 citation statements)

References 25 publications

(75 reference statements)

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“…For ASA, most studies have been observational, and the results have been conflicting. [19][20][21][22][23] For NSAIDs, most studies have been randomized controlled trials that have suggested that the NSAID celecoxib decreases the risk for de pression. 24,25 Among observational studies, a cross sectional study of 2800 healthy individuals found no association be tween NSAIDs and depressive symptoms, 26 whereas a large Danish study of 123 400 patients taking selective serotonin reuptake inhibitors (SSRIs) found that NSAID use increased the risk for depression.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory treatment and risk for depression

Wium‐Andersen

Jørgensen

et al. 2017

JPN

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory treatment and risk for depression

Wium‐Andersen

Jørgensen

et al. 2017

JPN

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“… 19 – 21 However, these studies were not confined to patients with already existing clinical psychological disorders along with CHF. Recently, Brouwers et al 22 studied the antidepressant effects on cardiac function and mortality and reported that the use of antidepressants in HF patients is associated with increased risk of all-cause and cardiovascular mortality. Similarly, it is of paramount importance to inversely study the β blocker effects on changes in psychological behavior in HF patients, as earlier reports on adverse associations have potentially limited the use of β blockers in vulnerable patients.…”

Section: Introductionmentioning

confidence: 99%

Impact of metoprolol treatment on mental status of chronic heart failure patients with neuropsychiatric disorders

Liu¹,

Lou²,

Cheng

et al. 2017

DDDT

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BackgroundMetoprolol treatment is well established for chronic heart failure (CHF) patients, but the central nervous system side effects are often a potential drawback.ObjectiveTo investigate the impact of metoprolol treatment on change in mental status of CHF patients with clinical psychological disorders (such as depression, anxiety, and burnout syndrome).MethodsFrom February 2013 to April 2016, CHF patients with clinical mental disorders received metoprolol (23.75 or 47.5 mg, qd PO, dose escalated with 23.75 mg each time until target heart rate [HR] <70 bpm was achieved) at the Second Affiliated Hospital of Kunming Medical University. Mental status was assessed by means of the Hospital Anxiety and Depression Scale (HADS) and the Copenhagen Burnout Inventory (CBI) scale. The primary outcome assessed was change in mental status of patients post-metoprolol treatment and the association with reduction in HR achieved by metoprolol.ResultsA total of 154 patients (median age: 66.39 years; males: n=101) were divided into eight groups on the basis of their mental status. HR decreased significantly from baseline values in all the groups to <70 bpm in the 12th month, P≤0.0001. The HADS depression and CBI scores significantly increased from baseline throughout the study frame (P≤0.0001 for all groups), but a significant decrease in the HADS anxiety score was observed in patients with anxiety (P≤0.0001 for all groups). Regression analysis revealed no significant correlation in any of the groups between the HR reduction and the change in the HADS/CBI scores, except for a change in the CBI scores of CHF patients with depression (P=0.01), which was HR dependent.ConclusionMetoprolol treatment worsens the depressive and high burnout symptoms, but affords anxiolytic benefits independent of HR reduction in CHF patients with clinical mental disorders. Hence, physicians need to be vigilant while prescribing metoprolol in CHF patients who present with mental disorders.

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“…Dest ravaux plus récents nous montrentq ue les antidépresseurs utilisésc hez l'insuffisant cardiaque dépressif sont inefficaces sur la surmortalité cardiaque [57] mais également sur la dépression des patients et une autre méta-analyse nous démontrent même leur caractère potentiellement dangereux [58].…”

Section: La Prise En Chargeunclassified

La psychocardiologie : une nouvelle spécialité

Houppe¹

2017

Hegel

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RésuméLe corps et l'esprit sont intimement liés. Les relations entre coeur et cerveau sont très fortes. La naissance de la psychocardiologie apparaîtc omme une évidence. Le stress psychosocial est à la fois un facteur de risque indépendant et un facteur pronostic d'événements cardiovasculaires. Il comprend des aspects psychologiques, des composantes sociologiques et socio-économiques. Il apparaîta ussi que la maladie cardiaque est elle-même un événement déclenchant de stress psychosocial.Les recommandations européennes sont de grade 1A pour l'évaluation du risque psychosocial et de grade 1B pour la prise en charge.Les connaissances actuelles sur le développement cérébral permettent de mieux comprendre la relation qui existe entre le stress psychosocial et le risque cardiovasculaire. Le risque psychosocial augmente les facteurs de risque classiques et entraîne par ailleurs une dysfonction endothéliale, une réponse inflammatoire et une activation de la coagulation.Les anxiolytiques et les antidépresseurs ne sont pas très efficaces dans la prise en charge du stress psychosocial, en revanche l'activité physique et les psychothérapies sont plus indiquées en particulier les thérapies cognitivo-comportementales, les thérapies de la pleine conscience et la thérapie EMDR.Depuis qu'il a été proposéàla find es années 70, le modèle biopsychosocial ne cesse d'accumuler des preuves de sa pertinence. Les recherches en médecine psychosomatique ,e nc ardiologie et en psychologie de la santé ont permis de faire en sorte que la psychocardiologie devienne une nouvelle spécialité fondées ur l'evidence based medicine. Il reste maintenant à faire en sorte que ces connaissances puissent être transmises aux praticiens et qu'ils puissent inclure cet aspect dans leur pratique quotidienne. Mots-clésCardiologie ;P sychocardiologie ;S tress psychosocial ;P sychothérapie ;P r é vention cardiaque Abstract Body and mind are closely linked. The relationships between the brain and the heart are very strong.T he emergence of pyschocardiology appears to be as imple truism. On the one hand

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Antidepressant use and risk for mortality in 121,252 heart failure patients with or without a diagnosis of clinical depression

Cited by 49 publications

References 25 publications

Anti-inflammatory treatment and risk for depression

Anti-inflammatory treatment and risk for depression

Impact of metoprolol treatment on mental status of chronic heart failure patients with neuropsychiatric disorders

La psychocardiologie : une nouvelle spécialité

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