Antidepressant Treatment of Geriatric Depression

Ciraulo, Domenic A.; Evans, James A.; Qiu, Wei Qiao; Shader, Richard I.; Salzman, Carl

doi:10.1007/978-1-60327-435-7_3

Cited by 5 publications

(3 citation statements)

References 349 publications

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“…This is more or less equivalent to a score of ≤7 on the HAM-D 17 . 8 , 9 The Integral Inventory for Depression (IID) 35 was used to measure the emotional and painful symptoms of MDD. The IID integrates the emotional items from the Mental Health Inventory-5 (MHI-5) 36 and the pain-related items from the Somatic Symptom Inventory (SSI) 37 which was modified to add items 27 (joint pain) and 28 (neck pain).…”

Section: Methodsmentioning

confidence: 99%

“…Recovery is usually defined as sustained remission for a longer period of time. The operational criteria encompass 1) severity of symptoms assessed through symptom measurement instruments (eg, the Hamilton Depression Rating Scale; HAM-D 17 ) 8 , 9 and 2) duration or a certain period of time. 10 A reduction in symptom severity of ≥50% during the course of treatment became an indicator of clinical response, that is, a clinically significant improvement.…”

Section: Introductionmentioning

confidence: 99%

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Recovery in patients with major depressive disorder (MDD): results of a 6-month, multinational, observational study

Novick¹,

Montgomery²,

Vorstenbosch³

et al. 2017

PPA

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Not all individuals treated for major depressive disorder (MDD) achieve recovery. This observational study examined the recovery rates in MDD patients and the patient characteristics associated with achieving recovery in a naturalistic clinical setting. Recovery was defined as having both clinical and functional remission. Data for this post hoc analysis were taken from a 24-week prospective, observational study that involved 1,549 MDD patients. Clinical remission was assessed using the 16-item Quick Inventory of Depressive Symptomatology Self-Report and functional remission through the Sheehan Disability Scale and no days of reduced productivity in the previous week. Generalized estimating equation regression models were used to examine the baseline factors associated with recovery during follow-up. Clinical and functional remission was achieved in 70.6% and 56.1% of the MDD patients, respectively. MDD patients who achieved recovery (52.1%) were significantly less likely to have impaired levels of functioning, concurrent medical or psychiatric conditions, low levels of education, or nonadherence to therapy at follow-up. The level of functioning during the index episode seems to be a better predictor of recovery than symptom severity. Therefore, the level of functioning should be considered while determining recovery from depression.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recovery in patients with major depressive disorder (MDD): results of a 6-month, multinational, observational study

Novick¹,

Montgomery²,

Vorstenbosch³

et al. 2017

PPA

View full text Add to dashboard Cite

show abstract

“…Geriatric depression has reported prevalence rates of 1.6 to 15% of the population 1 . New effective fast-acting treatment modalities in this population would be cost saving and alleviate suffering and disability for the patients and their families.…”

mentioning

confidence: 99%