Antidepressant Treatment During Pregnancy

Abstract

C o m m e n t a r y A m J Psych ia try 1 6 9 :2 , Feb ru a ry 2 0 1 2 a jp.p sych ia tryo n lin e.o rg A m J Psych ia try 1 6 9 :2 , Feb ru a ry 2 0 1 2 a jp.p sych ia tryo n lin e.o rg

Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study

“…However, if the association actually reflects the risk of autism spectrum disorder related to the non-genetic effects of severe depression during pregnancy, treatment may reduce the risk. Informed decisions would also need to consider weighing the wider risks of untreated depression40 41 with the other adverse outcomes related to antidepressant use 4042 43 44 45 46 With the current evidence, if the potential risk of autism were a consideration in the decision making process, it may be reasonable to think about, wherever appropriate, non-drug approaches such as psychological treatments.…”

Infant Health and Neurodevelopmental Outcomes Following Prenatal Exposure to Duloxetine

“…Despite reassuring information reported in our case and in the international literature, little data are available on the safety of duloxetine during pregnancy; therefore, its use should not routinely be recommended as first-line treatment. It goes without saying that, in clinical practice, the potential embryo/fetal toxicity of the antidepressant treatment needs to be assessed and balanced against the risk of untreated depression [7,[27][28][29], as well as the increased risk of postpartum depression [30].…”

Tratamento farmacológico da depressão na mulher grávida

“…A depressão e a ansiedade não tratadas durante a gravidez podem representar um risco tanto para a mãe como para o filho e têm sido relacionadas com diversas consequências negativas para o feto, tanto a nível emocional e comportamental, quanto físico. Na tabela 1 apresentam-se os efeitos no embrião/feto e no recém-nascido, descritos na literatura, a que a depressão parece estar associada [5,[18][19][20][21][22] .…”