Antidepressant therapy in tinnitus

Robinson, Shannon K.; Viirre, Erik; Stein, Murray B.

doi:10.1016/j.heares.2006.08.004

Cited by 84 publications

(62 citation statements)

References 33 publications

(54 reference statements)

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“…Medications have been shown to have variable success with no strong evidence showing superior efficacy of any one antidepressant 34,35 . Nortripyline, has had mixed results with two randomized placebo based studies resulting in a decrease in depressive and tinnitus symptoms when compared to the placebo group 36,37 while another suggests no difference between placebo 38 .…”

Section: Resultsmentioning

confidence: 99%

Tinnitus Patients Suffering from Anxiety and Depression: A Review

Ziai¹,

Moshtaghi²,

Mahboubi³

et al. 2017

The International Tinnitus Journal

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Objectives: To review literature on the link between depression and anxiety in patients suffering from tinnitus. Method: A systematic review of published English-language literature was performed using PubMed, Ovid, and Cochrane databases. Results: Of the 56 eligible abstracts 15 were chosen to be included in the review. All articles showed an association of depression and anxiety in tinnitus patients. Conclusions: Because of the strong association between tinnitus, depression, and anxiety-all tinnitus patients should be screened for psychiatric disorders. Treatment for these complex conditions should involve a multidisciplinary team with cognitive behavioral therapy and possible pharmacological therapy.

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Section: Resultsmentioning

confidence: 99%

Tinnitus Patients Suffering from Anxiety and Depression: A Review

Ziai¹,

Moshtaghi²,

Mahboubi³

et al. 2017

The International Tinnitus Journal

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“…This has been primarily because of the complexity of the central nervous system, and the multifactorial causes of tinnitus. 14 Other drugs already studied for treatment of tinnitus are baclofen (improvement in about 9.7%), 15 caroverine (63.3%), 16 nimodipine (16.13%), 17 clonazepam (32%) 18 and trimetazidine (89%). 19 Different studies have shown that sensorineural tinnitus is caused by an imbalance of two neurotransmitters Glutamate and GABA in the auditory pathway.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Acamprosate With Other Drugs in Central Tinnitus

Kaur¹,

Jyoti²

2013

jemds

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AIM:To compare the efficacy of acamprosate with other drugs to decrease the severity of sensorineural tinnitus. MATERIAL AND METHOD: The study was randomised double-blind, placebo controlled, crossover. Forty adult subjects (>18 years of age), of either sex with tinnitus of sensorineural origin, were administered either acamprosate 333 mg tds or matched placebo for a period of six weeks followed by a washout period of one week. Drug therapy was switched for another six weeks in consonance with the crossover design. The effect of acamprosate and placebo on subjective relief and objective improvement was evaluated by using modified tinnitus severity quality of life scores and audiometry with tinnitus matching in frequency and loudness. RESULTS: At the end of study the drug had shown a statistically significant improvement in reducing the tinnitus score in 92.5% of the patients and placebo with an improvement in 12.5% of the patients in contrast to other drugs belonging to this group. CONCLUSION: Acamprosate is an effective drug in treating the severity of sensorineural tinnitus

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“…This is hardly unexpected: In people for whom tinnitus is distressing, anxiety about its presence, and depression about its uncontrollability, will surely be elevated. Robinson et al (2004) also report on tinnitus as either caused by, as a withdrawal symptom from, or as improved by treatments using antidepressants. A contrast is made between earlier "tricyclic" antidepressants and the more recently manufactured "selective serotonin reuptake inhibitors," with the tricyclates having a broader spectrum in their inhibitory biochemistry.…”

Section: Forms Of Treatmentmentioning

confidence: 99%

“…From the review by Robinson et al (2004), it is difficult to distinguish between these two groups of compounds in terms of effect on tinnitus (either as producing or diminishing it). Where a beneficial outcome from use of the newer antidepressants is observed, it is in terms of tinnitus being reported as less aggravating, bothersome, or annoying (Folmer, Griest, Bonaduce, & Edlefsen, 2002;Zöger, Svedlund, & Holgers, 2006).…”

Section: Forms Of Treatmentmentioning

confidence: 99%

Treatments for Tinnitus

Noble

2008

Trends in Amplification

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The various forms of treatment for tinnitus that have been tested in properly controlled trials can be classified as pharmacological, acoustic—physical, and psychological. In clinical trials, no pharmacological agent has been shown to have lasting effect on the presence or severity of tinnitus, although there are promising signs in an animal model. Acoustic devices do not seem to influence tinnitus, although appropriately fitted hearing aids may slightly reduce its prominence. Of physical treatments, cortical implantation may hold some promise of being effective for tinnitus suppression in selected cases. A psychological treatment that has emerged as consistently beneficial is cognitive-behavior therapy in terms of affecting overall well-being and reducing level of tinnitus annoyance.

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Antidepressant therapy in tinnitus

Cited by 84 publications

References 33 publications

Tinnitus Patients Suffering from Anxiety and Depression: A Review

Tinnitus Patients Suffering from Anxiety and Depression: A Review

Comparative Evaluation of Acamprosate With Other Drugs in Central Tinnitus

Treatments for Tinnitus

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