Antidepressant ‘Rookies’ Are More Likely to Quit

Unraveling Anxiety and Depression

“…15,41 Mirtazapine Mirtazapine is also recommended as a first-line medication treatment and is an alpha-2 antagonist, noradrenaline, and specific serotonergic agent; therefore, it is a dual serotonin and norepinephrine antidepressant. It is effective in treating social anxiety disorder 40 but has mixed results for combination with SSRIs for treatment-resistant depression.…”

“…8 The stressdiathesis model demonstrates that vulnerability preexists for some patients and that under stressful conditions, such as chronic or protracted acute illnesses, anxiety and depression may express themselves. 15 When anxiety is the predominant presenting condition, patients present with fear and nonspecific worry not associated with a particular issue or event, often accompanied by repetitive, intrusive, and inappropriate thoughts or actions. 4,5,10 Cross-sectional or snapshot assessments common in primary care do not recognize the longitudinal nature of these disorders.…”