Antidepressant-like Property of Jobelyn®, an African Unique Herbal Formulation, in Mice

Umukoro, Solomon; Eduviere, Anthony T.; Olugbemide, Abimbola S.

doi:10.1055/s-0033-1354366

Cited by 6 publications

(9 citation statements)

References 23 publications

(11 reference statements)

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“…Moreover, JB has gained international recognition as a remedy for treatment of anaemia, arthritic pains and relief of stress [17]. We have previously reported that JB exhibited anti-depressant and anti-amnesic properties in rodents [18] [19]. In this present study, we report on the effect of Jobelyn ® on unpredictable chronic mild stress-induced memory impairment in mice.…”

Section: Introductionmentioning

confidence: 65%

Jobelyn&reg;, a Sorghum-Based Nutritional Supplement Attenuates Unpredictable Chronic Mild Stress-Induced Memory Deficits in Mice

Umukoro¹,

Omorogbe²,

Aluko³

et al. 2015

JBBS

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The ability of an organism to adapt to aversive stressful situations or life challenging circumstances is very crucial to its state of health and survival. However, breakdown in adaptation due to persistent uncontrollable stress, leads to impairment of bodily functions and onset of a variety of pathological disorders especially memory decline. This study was designed to evaluate the effect of Jobelyn ® (JB), a potent antioxidant sorghum-based food supplement on unpredictable chronic mild stress (UCMS)-induced memory impairment in mice. Male Swiss mice were given JB (5-50 mg/kg, p.o) 30 min prior to exposure to UCMS for 14 consecutive days before testing for memory. Thereafter, the serum corticosterone level was estimated by using ELISA kits. The levels of malondialdehyde (MDA) and glutathione (GSH) as well as acetylcholinesterase activity were estimated in the brain homogenate using spectrophotometer. Histology of the brain tissues and estimation of the populations of viable neurons in the hippocampal region were done after staining with hematoxyline and eosin. Our results showed that JB reversed memory impairment and suppressed corticosterone concentrations induced by UCMS. Moreover, JB reduced oxidative stress in the brain of UCMS-mice as shown by decreased MDA levels and elevated GSH concentrations. It also decreased * Corresponding author. S. Umukoro et al. 587 brain acetylcholinesterase activity when compared with chronic stress group (p < 0.05). Furthermore, JB (5-10 mg/kg, p.o) offered significant protection against UCMS-induced degeneration and death of neuronal cells of the cornu ammonis 3 (CA3) of the hippocampal region of the brain indicating neuroprotection. Taken together, these findings suggest that JB attenuates memory deficits induced by UCMS in mice and may be useful therapeutically for stress-related cognitive dysfunctions. The reduction in the levels of serum corticosterone, antioxidation, neuroprotection and inhibition of cholinesterase enzyme might be contributing significantly to the positive effect of JB on memory in mice exposed to unpredictable chronic mild stress.

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Section: Introductionmentioning

confidence: 65%

Jobelyn&reg;, a Sorghum-Based Nutritional Supplement Attenuates Unpredictable Chronic Mild Stress-Induced Memory Deficits in Mice

Umukoro¹,

Omorogbe²,

Aluko³

et al. 2015

JBBS

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“…This is especially important in a developing African context, where the high cost of conventional therapies hinders drug compliance and contributes to disease-related morbidity and mortality. The results from such clinical trials are necessary, as they are expected to provide the evidential strength that researchers need to significantly reduce some of the barriers to the clinical adoption of validated indigenous phytomedicines [121] in mainstream medical practice.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the ability of SBSJ to reduce corticosterone is an important finding from the study of Umukoro et al [120]. The possibility of SBSJ behaving like an adaptogen is also based on findings that it attenuated depression-like symptoms in mice subjected to stressful situations (i.e., forced swimming exercise and tail suspension protocols) [121]. In an in vitro stress model, it has also been reported that SBSJ protected RBCs against hyposaline-induced haemolysis [43], suggesting cyto-protection and increased cellular resistance to stress.…”

Section: Sbsj As An Adaptogenmentioning

confidence: 99%

Polyphenol Rich Nutritional Supplement Derived from the West African Sorghum Bicolor Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Okubena¹,

Adebesin²,

Omogbiya³

et al. 2022

Preprint

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Across different cultures around the globe, human beings have historically depended largely on medicinal plants for managing diseases that have hitherto threatened their optimal health, survival, and longevity. Evidently, the health-derived benefits of medicinal plants can be strongly attributed to the presence of secondary metabolites, particularly polyphenols. The health-promoting effects of Sorghum bicolor supplement Jobelyn® (SBSJ) —a unique supplement derived from the leaf sheaths of a West African variety of Sorghum bicolor (L.) Moench—have also been ascribed to its high levels of polyphenols. This review seeks to gather and synthesize findings from various experimental and clinical studies on the health benefits of SBSJ in arthritis, cancer, chronic viral infections, stroke, anaemia, and aging. SBSJ has been reported to contain potent bioactive polyphenolic compounds with polyvalent biological activities, including antioxidant, anti-inflammatory, immunomodulatory, chemopreventive, and neuroprotective activities. Moreover, the probable benefits of SBSJ in chronic viral infections (e.g., HIV/AIDS and COVID-19) have been attributed to its potent anti-inflammatory and immunomodulatory activities. As this supplement is increasingly becoming one of the fastest-selling herbal medicines in Nigeria, there is a need for more robust studies (including clinical trials) in order to replicate and validate the prior insights gleaned from experimental studies.

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“…In the same study, interferon-alpha (IFN-), an antiviral cytokine showed increased expression by 12-fold following treatment with SBLS extract. 29 There seems to be a correlation between high IFN-production capacities and low HIV viral loads as well as high CD4 cell counts and lack of opportunistic infections. 30,31 This effect can be related to the direct anti-viral role of IFN-on infected HIV cells.…”

Section: Anti-inflammatory Effects Of the Sbls Extracts On Cytokines mentioning

confidence: 99%

The West African Sorghum Bicolor Leaf Sheath Extract Jobelyn® and Its Diverse Therapeutic Potentials

Okubena¹,

Makanjuola²,

Ajonuma³

et al. 2017

Preprint

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The West-African variety of Sorghum bicolor leaf sheath (SBLS) Jobelyn® is a natural remedy, which has gained international recognition for its anti-anaemic effect and energy boosting qualities in debilitating diseases. The widespread use of traditional medicine in the region usually confirms its safety, but not its efficacy or deep assessment of their pharmacological properties. The other major issue for herbal-based treatments is the lack of definite and complete information about the composition of the extracts. Despite limitations, efforts have been made in isolation and characterisation of active compounds in this specie of Sorghum showing various subclasses of flavonoids including apigeninidin, a stable 3-deoxyanthocyanidin and potential fungal growth inhibitor, which accounts for 84% of the total extract. Nonclinical in vitro and in vivo studies support previous indications that this variety of Sorghum bicolor possesses several biologically active compounds with potent antioxidant, anti-inflammatory, anti-aging and neuro-protective properties. Clinical studies show that SBLS has the ability to boost haemoglobin concentrations in anaemic conditions and most remarkably to increase CD4 count in HIV-positive patients. The multiple effects and high safety profiles of this extract may encourage its development as a therapeutic agent for the treatment of anemia, chronic inflammatory conditions or in the symptomatic management of HIV infections. This review describes the potential therapeutic aspects of SBLS extract and its potential benefits.

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Antidepressant-like Property of Jobelyn®, an African Unique Herbal Formulation, in Mice

Abstract: Jobelyn® has antidepressant-like activity, which may be related to the stimulation of serotonergic and noradrenergic pathways. The ability of Jobelyn® to delay the onset of immobility and to prolong the struggling time support its use as energizer in general body weakness or exhaustion.

Cited by 6 publications

References 23 publications

Jobelyn<sup>&reg;</sup>, a Sorghum-Based Nutritional Supplement Attenuates Unpredictable Chronic Mild Stress-Induced Memory Deficits in Mice

Jobelyn<sup>&reg;</sup>, a Sorghum-Based Nutritional Supplement Attenuates Unpredictable Chronic Mild Stress-Induced Memory Deficits in Mice

Polyphenol Rich Nutritional Supplement Derived from the West African <em>Sorghum Bicolor</em> Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

The West African <em>Sorghum Bicolor </em>Leaf Sheath Extract Jobelyn® and Its Diverse Therapeutic Potentials

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Antidepressant-like Property of Jobelyn®, an African Unique Herbal Formulation, in Mice

Abstract: Jobelyn® has antidepressant-like activity, which may be related to the stimulation of serotonergic and noradrenergic pathways. The ability of Jobelyn® to delay the onset of immobility and to prolong the struggling time support its use as energizer in general body weakness or exhaustion.

Cited by 6 publications

References 23 publications

Jobelyn&lt;sup&gt;&amp;reg;&lt;/sup&gt;, a Sorghum-Based Nutritional Supplement Attenuates Unpredictable Chronic Mild Stress-Induced Memory Deficits in Mice

Jobelyn&lt;sup&gt;&amp;reg;&lt;/sup&gt;, a Sorghum-Based Nutritional Supplement Attenuates Unpredictable Chronic Mild Stress-Induced Memory Deficits in Mice

Polyphenol Rich Nutritional Supplement Derived from the West African <em>Sorghum Bicolor</em> Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

The West African&nbsp;<em>Sorghum Bicolor </em>Leaf Sheath Extract Jobelyn&reg; and Its Diverse Therapeutic Potentials

Contact Info

Product

Resources

About

Jobelyn<sup>®</sup>, a Sorghum-Based Nutritional Supplement Attenuates Unpredictable Chronic Mild Stress-Induced Memory Deficits in Mice

Jobelyn<sup>®</sup>, a Sorghum-Based Nutritional Supplement Attenuates Unpredictable Chronic Mild Stress-Induced Memory Deficits in Mice

The West African <em>Sorghum Bicolor </em>Leaf Sheath Extract Jobelyn® and Its Diverse Therapeutic Potentials