Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress

Su, Guang Yue; Yang, Jing; Wang, Fang; Ma, Jie; Zhang, Kuo; Dong, Ying; Song, Shao Jiang; Lu, Xiu Mei; Wu, Chun Fu

doi:10.1016/j.jep.2014.01.006

Cited by 80 publications

(60 citation statements)

References 63 publications

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“…The results of our study indicated that the CUMS procedure significantly decreased the exploratory activity in the CUMS control group. Previous studies indicated that the CUMS procedure decreased the exploratory activity in open field test [39, 43, 48]. Furthermore, our results indicated that the treatment with fluoxetine (10 mg/kg) for 4 weeks reversed the decreased exploratory activity induced by CUMS procedure in open field test.…”

Section: Discussionsupporting

confidence: 71%

“…The sucrose preference test was conducted based on previously published protocols [13, 34] with minor modifications as described in previous studies [32, 39]. The animals were individually housed in a cage and given two bottles of 1% w/v sucrose solution 72 hr before the actual test on first week Sunday morning.…”

Section: Methodsmentioning

confidence: 99%

“…The weight of both bottles was recorded and the difference in their respective initial and final weights was calculated. The percentage of sucrose preference was calculated based on the following formula [39]:

\begin{matrix} T3 \\ %  Sucrose  preference \\ = \frac{Sucrose  consumption}{Sucrose  +  Water  consumption} \times 100 \end{matrix}

The sucrose preference test was conducted every Sunday morning.…”

Section: Methodsmentioning

confidence: 99%

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Antidepressant‐Like Effect of Lipid Extract of Channa striatus in Chronic Unpredictable Mild Stress Model of Depression in Rats

Shukkoor

Baharuldin

Jais

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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This study evaluated the antidepressant-like effect of lipid extract of C. striatus in chronic unpredictable mild stress (CUMS) model of depression in male rats and its mechanism of action. The animals were subjected to CUMS for six weeks by using variety of stressors. At the end of CUMS protocol, animals were subjected to forced swimming test (FST) and open field test followed by biochemical assay. The CUMS protocol produced depressive-like behavior in rats by decreasing the body weight, decreasing the sucrose preference, and increasing the duration of immobility in FST. The CUMS protocol increased plasma corticosterone and decreased hippocampal and prefrontal cortex levels of monoamines (serotonin, noradrenaline, and dopamine) and brain-derived neurotrophic factor. Further, the CUMS protocol increased interleukin-6 (in hippocampus and prefrontal cortex) and nuclear factor-kappa B (in prefrontal cortex but not in hippocampus). The lipid extract of C. striatus (125, 250, and 500 mg/kg) significantly (p < 0.05) reversed all the above parameters in rats subjected to CUMS, thus exhibiting antidepressant-like effect. The mechanism was found to be mediated through decrease in plasma corticosterone, increase in serotonin levels in prefrontal cortex, increase in dopamine and noradrenaline levels in hippocampus and prefrontal cortex, increase in BDNF in hippocampus and prefrontal cortex, and decrease in IL-6 and NF-κB in prefrontal cortex.

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Section: Discussionsupporting

confidence: 71%

Section: Methodsmentioning

confidence: 99%

\begin{matrix} T3 \\ %  Sucrose  preference \\ = \frac{Sucrose  consumption}{Sucrose  +  Water  consumption} \times 100 \end{matrix}

The sucrose preference test was conducted every Sunday morning.…”

Section: Methodsmentioning

confidence: 99%

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Antidepressant‐Like Effect of Lipid Extract of Channa striatus in Chronic Unpredictable Mild Stress Model of Depression in Rats

Shukkoor

Baharuldin

Jais

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…The body weights of the rats in the CUMS group were significantly reduced compared with the control group. This finding may be related to lower food intake (Su et al, ). In the behavioral tests, the number of activities was reduced in the OFT in the CUMS group.…”

Section: Discussionmentioning

confidence: 98%

Metabolic profiles revealed synergistically antidepressant effects of lilies and Rhizoma Anemarrhenae in a rat model of depression

Zhao

Lai

et al. 2017

Biomedical Chromatography

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Depression is a major cause of illness and disability. We applied untargeted metabolomics using mass spectrometry to identify metabolic signatures associated with depression in serum and explored the antidepressant effects of lilies and Rhizoma Anemarrhenae on an experimental model of chronic unpredictable mild stress (CUMS). Meanwhile metabolomics based on UHPLC-Q-TOF-MS was used to study the change in metabolites in CUMS rat serum and to evaluate the effects of Rhizoma Anemarrhenae and lilies (alone and in combination). Partial least squares-discriminant analysis identified 30 metabolites as decisive marker compounds that discriminated the CUMS rats and the control rats. The majority of these metabolites were involved in amino acid metabolism, the tricarboxylic acid cycle, and phosphoglyceride metabolism. The reliability of the metabolites was evaluated by the administration of lilies, Rhizoma Anemarrhenae, fluoxetine and the combination of lilies and Rhizoma Anemarrhenae to the CUMS rats. Behavior studies demonstrated that treatment with the combination of lilies and Rhizoma Anemarrhenae resulted in optimal antidepressant effects. The combination treatment was almost as effective as fluoxetine. Our results suggest that lilies and Rhizoma Anemarrhenae demonstrate synergistically antidepressant effects in CUMS via the regulation of multiple metabolic pathways. These findings provide insight into the pathophysiological mechanisms underlying CUMS and suggest innovative and effective treatments for this disorder.

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“…Moreover, XCHT significantly increases 5-HT and dopamine levels and improves cerebral expression of all factors (including BDNF), which were reduced in rats expressing symptoms of anhedonia. Therefore, these studies suggest that XCHT may have therapeutic effect in the treatment of depression and any related symptoms [22].…”

Section: Drugs Evaluated In the Cums Modelmentioning

confidence: 90%

Utility of the chronic unpredictable mild stress model in research on new antidepressants

Pekala

Budzyńska

Biała

2014

Current Issues in Pharmacy and Medical Sciences

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conducted in order to mimic the similarities of clinical symptoms of depression, in laboratory condition. These models make testing many factors involved in the pathogenesis, etiology, symptomatology, and the pharmacological treatment of depression possible [2].The incidence of depression and its negative consequences still have been intensely studied. The "ideal" animal model of depression should have as many criteria specific to depression in humans as possible, should be sensitive to antidepressants, and should identify similarities in the pathophysiology and etiology of different kind of depressive states [31]. It should be noted that animal models of depression do not always reflect all the irregularities of depression in humans. However, patients do not always reveal all possible symptoms of this disease, either. We may mention here anhedonia, one of the primary symptoms of depression in humans, whereas most of the current animal models of depression only mimic it [9]. MODELS OF DEPRESSIONCurrently, many various models of depression have been used to mimic depressive state in humans. Each model has advantages and disadvantages. The most commonly used paradigms are as follows:Learned helplessness. In this paradigm the depressive state is induced by uncontrolled and unpredictable electric shock in rodents. Model of learned helplessness was firstly used at the early 60's. In these experiments, animals are Unpredictable chronic mild stress model was developed as an animal model of depression more than 20 years ago. Essential for this model is that after prolonged exposure of tested animals to a series of unpredictable mild stressors, a condition similar to anhedonia develops, which is observed in the majority of depressive disorders. Unpredictable chronic mild stress model is used nowadays in numerous studies related to the neurobiological and biochemical changes associated with depressive illness. Their results confirm that chronic unpredictable mild stress induces in tested animals a number of changes, which reflect those seen in depressive disorders. Because the effects of unpredictable chronic mild stress can be used in a more accurate diagnosis of the pathophysiology of depressive illness and expand knowledge of its pharmacotherapy, therefore research in this area has been continued all the time.

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Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress

Cited by 80 publications

References 63 publications

Antidepressant‐Like Effect of Lipid Extract of Channa striatus in Chronic Unpredictable Mild Stress Model of Depression in Rats

Antidepressant‐Like Effect of Lipid Extract of Channa striatus in Chronic Unpredictable Mild Stress Model of Depression in Rats

Metabolic profiles revealed synergistically antidepressant effects of lilies and Rhizoma Anemarrhenae in a rat model of depression

Utility of the chronic unpredictable mild stress model in research on new antidepressants

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