Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents

Xu, Qing‐Long; Yi, Long; Pan, Ying; Wang, Xing; Liu, Yucheng; Li, Jianmei; Wang, Caiping; Kong, Ling-Dong

doi:10.1016/j.pnpbp.2007.11.020

Cited by 152 publications

(107 citation statements)

References 70 publications

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“…The antidepressant effects of magnolol and honokiol in this study were attributed to the repair of the induced disturbance in serotonergic system, HPA axis, and AC-cAMP pathway (Xu et al, 2008).…”

Section: Magnolia Officinalismentioning

confidence: 59%

“…Excessive release of glucocorticoid hormones, such as corticosterone in mice and cortisol in humans, that are produced in response to stressful conditions, is also an indicator of HPA axis excessive activity and development of depression (Xu et al, 2008). Fluoxetine has been demonstrated to be able to decrease the escalated amounts of serum corticosterone in mice with depression (Song et al, 2006).…”

Section: Biomarkers To Study Depressionmentioning

confidence: 99%

“…Therefore, adenylyl cyclase activity can be considered to be the biological index of depression (Li et al, 1999). Adenylyl cyclase activity is controlled by serotonergic system receptors; serotonergic system, HPA axis, and adenylyl cyclasecAMP pathway have been demonstrated to interact with each other due to chronic stress in rats with depression (Xu et al, 2008).…”

Section: Biomarkers To Study Depressionmentioning

confidence: 99%

“…Magnolia officinalis, M. dealbata, M. obovata, and M. grandiflora are the plants from family Magnoliacea which are used to treat neurological diseases such as convulsion, seizure, depression, and anxiety and as sedative and painkiller (Xu et al, 2008;Chen et al, 2011). These plants are the main constituents of the herbal drugs used in Japan and China such as Banxiahoupu and Saiboku-to (Nakazawa et al, 2003).…”

Section: Magnolia Officinalismentioning

confidence: 99%

“…These compounds have been reported to cause antidepressant effects through affecting serotonergic system (Kuribara et al, 1998). Xu et al (2008) investigated the effect of the oral use of these two compounds on mild chronic stressinduced depression. Mild chronic stress caused decrease in 5-HT and its metabolite, 5-HIAA, in different regions of the brain and suppressed the activity of platelets adenylyl cyclase.…”

Section: Magnolia Officinalismentioning

confidence: 99%

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A review on antidepressant effect of medicinal plants

Rabiei

2017

Bangladesh J Pharmacol

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<p class="Abstract">Depression is a life-threatening, debilitating, and common disease affecting different segments of community. Chemical and synthetic drugs available to treat this disease cause many adverse effects and may lead to complete recovery in only 50% of patients. At the same time, medicinal plants have been reported to exert optimal pharmacological effects in treating depression in different models. In this review, the relevant articles indexed in the reliable databases PubMed, PubMed central, Scopus and Web of Science were review-ed. The review indicated that most medicinal plants exerted antidepressant effects through synaptic regulation of serotonin, noradrenaline, and dopamine, regulating activity of hypothalamic-pituitary-adrenal axis, reinfor-cing anti-oxidant defense system, and decreasing inflammatory mediators. The medicinal plants and their active compounds can relieve depression through different pathways and hence are considered a new source to produce antidepressants.</p>

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Section: Magnolia Officinalismentioning

confidence: 59%

Section: Biomarkers To Study Depressionmentioning

confidence: 99%

Section: Biomarkers To Study Depressionmentioning

confidence: 99%

Section: Magnolia Officinalismentioning

confidence: 99%

Section: Magnolia Officinalismentioning

confidence: 99%

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A review on antidepressant effect of medicinal plants

Rabiei

2017

Bangladesh J Pharmacol

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4‐O‐methylhonokiol Inhibits Serious Embryo Anomalies Caused by Nicotine via Modulations of Oxidative Stress, Apoptosis, and Inflammation

Cai

Yon

Hong

et al. 2014

Birth Defects Research Pt B

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Neuroprotective effects of honokiol: from chemistry to medicine

et al. 2017

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The incidence of neurological disorders is growing in developed countries together with increased lifespan. Nowadays, there are still no effective treatments for neurodegenerative pathologies, which make necessary to search for new therapeutic agents. Natural products, most of them used in traditional medicine, are considered promising alternatives for the treatment of neurodegenerative diseases. Honokiol is a natural bioactive phenylpropanoid compound, belonging to the class of neolignan, found in notable amounts in the bark of Magnolia tree, and has been reported to exert diverse pharmacological properties including neuroprotective activities. Honokiol can permeate the blood brain barrier and the blood-cerebrospinal fluid to increase its bioavailability in neurological tissues. Diverse studies have provided evidence on the neuroprotective effect of honokiol in the central nervous system, due to its potent antioxidant activity, and amelioration of the excitotoxicity mainly related to the blockade of glutamate receptors and reduction in neuroinflammation. In addition, recent studies suggest that honokiol can attenuate neurotoxicity exerted by abnormally aggregated Aβ in Alzheimer's disease. The present work summarizes what is currently known concerning the neuroprotective effects of honokiol and its potential molecular mechanisms of action, which make it considered as a promising agent in the treatment and management of neurodegenerative diseases. © 2017 BioFactors, 43(6):760-769, 2017.

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Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents

Cited by 152 publications

References 70 publications

A review on antidepressant effect of medicinal plants

A review on antidepressant effect of medicinal plants

4‐O‐methylhonokiol Inhibits Serious Embryo Anomalies Caused by Nicotine via Modulations of Oxidative Stress, Apoptosis, and Inflammation

Neuroprotective effects of honokiol: from chemistry to medicine

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