Antidepressant-like effects of the extract from Cimicifuga foetida L.

Liang, Y. T.; Hu, Zhengping; Du, Guangying; Zhang, Jianzhao; Dong, Qiuju; Fu, Fenghua; Tian, Jingwei

doi:10.1016/j.jep.2012.10.013

Cited by 32 publications

(27 citation statements)

References 46 publications

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“…Forced swimming test (FST) was performed according to the previous method (Ye et al, 2012). Briefly, the animal was individually forced to swim in a glass cylinder (25 cm high, 12 cm in diameter) filled with water (22 ± 2°C) to a depth of 15 cm.…”

Section: Forced Swimming Test In Micementioning

confidence: 99%

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Tris-(2,3-dibromopropyl) isocyanurate induces depression-like behaviors and neurotoxicity by oxidative damage and cell apoptosis in vitro and in vivo

Dong

Zhu

et al. 2015

J. Toxicol. Sci.

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-Tris-(2,3-dibromopropyl) isocyanurate (TDBP-TAZTO), an emerging brominated flame retardant, possesses the characteristics of candidate persistent organic pollutants and has displayed toxicity to fish and rodents. TDBP-TAZTO can pass through the blood-brain barrier and accumulate in the brain. TDBP-TAZTO might also induce neuronal cell toxicity. However, the neurotoxicity and mechanisms of TDBP-TAZTO have not yet been studied. We hypothesize that TDBP-TAZTO could induce neurotoxicity in mouse hippocampal neurons and SH-SY5Y cells. The mice were exposed to TDBP-TAZ-TO of 5 and 50 mg/kg by gavage, daily for 30 days. TDBP-TAZTO resulted in depression-like behaviors, which may be related with TDBP-TAZTO-induced upregulation of oxidative stress markers and overexpression of pro-apoptotic proteins in hippocampus. Furthermore, TDBP-TAZTO treatment for 48 hr (12.5, 25 and 50 μM) damaged SH-SY5Y cells, and led to cell apoptosis and oxidative stress in concentrationdependent manner. Our findings suggested that cell apoptosis and oxidative stress are important mechanisms in neurotoxicity induced by TDBP-TAZTO.

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Section: Forced Swimming Test In Micementioning

confidence: 99%

“…Tail suspension test (TST) was performed according to the previous described method (Ye et al, 2012) with minor modification. Briefly, the mice were individually suspended 50 cm above the surface of table by fixing the tail using adhesive tape.…”

Section: Tail Suspension Test In Micementioning

confidence: 99%

Tris-(2,3-dibromopropyl) isocyanurate induces depression-like behaviors and neurotoxicity by oxidative damage and cell apoptosis in vitro and in vivo

Dong

Zhu

et al. 2015

J. Toxicol. Sci.

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“…Antagonism of a high dose of APO (16 mg/kg) induced hypothermia is proposed as an improved screening test for antidepressants inhibiting norepinephrine reuptake [37]. These two models are commonly used for the evaluation of a noradrenergic effect of antidepressant drugs [24,38]. In the present study, pretreatment with PA01 (16 and 32 mg/kg) significantly enhanced the mouse lethality induced by yohimbine as compared with the vehicle control group.…”

Section: Discussionmentioning

confidence: 57%

“…Yohimbine can produce excessive NE releasing by its antagonistic action on pre-synaptic α 2 -adrenoceptor [24], and APO acts on the presynaptic D 2 receptors situated on noradrenergic nerve terminals to inhibit the release of noradrenaline [25]. Antagonism of a high dose of APO (16 mg/kg) induced hypothermia is proposed as an improved screening test for antidepressants inhibiting norepinephrine reuptake [37].…”

Section: Discussionmentioning

confidence: 99%

“…Yohimbine toxicity potentiation test in mice. To evaluate a possible contribution of the noradrenergic system in the antidepressant activity of PA01, a test of yohimbine toxicity potentiation in mice was performed [24]. Seventy-five naive mice were randomly assigned to five groups (n = 15/group), and were treated with DVS (16 mg/kg), PA01 (8,16, and 32 mg/kg) or vehicle orally 60 min before yohimbine (25 mg/kg, s.c., a α 2 -adrenoceptor antagonist).…”

Section: The Depletion Of 5-ht In Mouse Tstmentioning

confidence: 99%

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In vitro and in vivo characterization of PA01, a novel promising triple reuptake inhibitor

Hou

Xing

Zuo

et al. 2015

Physiology & Behavior

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Simultaneous determination of 19 constituents in Cimicifugae Rhizoma by HPLC–DAD and screening for antioxidants through DPPH free radical scavenging assay

Niu

Qin

Zhao

et al. 2019

Biomedical Chromatography

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Cimicifugae Rhizoma (sheng ma) is a well-known traditional Chinese medicine, which has been demonstrated to possess anti-inflammatory, antipyretic and analgesic activities. In the present study, a simple and efficient HPLC-DAD (high-performance liquid chromatography coupled with diode array detection) method was developed and validated for simultaneous quantification of 19 chemical components (including 16 phenolic acids, one coumarin and two alkaloids) in Cimicifugae Rhizoma. The result indicated that this method could effectively evaluate the quality of Cimicifugae Rhizoma and provide a valuable reference for further study. Additionally, the antioxidant activity of Cimicifugae Rhizoma was evaluated by DPPH (1,1diphenyl-2-picrylhydrazyl) radical scavenging assay. The results showed that the content of phenolic acids and antioxidant activity exhibited significant correlation coefficients.

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Antidepressant-like effects of the extract from Cimicifuga foetida L.

Cited by 32 publications

References 46 publications

Tris-(2,3-dibromopropyl) isocyanurate induces depression-like behaviors and neurotoxicity by oxidative damage and cell apoptosis <i>in vitro</i> and <i>in vivo </i>

Tris-(2,3-dibromopropyl) isocyanurate induces depression-like behaviors and neurotoxicity by oxidative damage and cell apoptosis <i>in vitro</i> and <i>in vivo </i>

In vitro and in vivo characterization of PA01, a novel promising triple reuptake inhibitor

Simultaneous determination of 19 constituents in Cimicifugae Rhizoma by HPLC–DAD and screening for antioxidants through DPPH free radical scavenging assay

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