Antidepressant-like effects of Perilla frutescens seed oil during a forced swimming test

Lee, Hsiu Chuan; Ko, Hsiang Kai; Huang, Brian E T G; Chu, Yiyi; Huang, Shih Yi

doi:10.1039/c3fo60717h

Cited by 31 publications

(16 citation statements)

References 38 publications

(41 reference statements)

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“…Similarly, high taurine‐supplemented diet for 4 weeks had an antidepressant‐like effect in the forced swim test in rodents . Perilla frutescens seed oil‐rich diet exhibited antidepressant‐like properties through modulation of fatty acid profiles and BDNF expression in the brain . Nagasawa et al .…”

Section: Mechanism Of Actionmentioning

confidence: 98%

Effect of caloric restriction on depression

Manchishi

Cui

Zou

et al. 2018

J Cellular Molecular Medi

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Recently, most of evidence shows that caloric restriction could induce antidepressant‐like effects in animal model of depression. Based on studies of the brain–gut axis, some signal pathways were common between the control of caloric restriction and depression. However, the specific mechanism of the antidepressant‐like effects induced by caloric restriction remains unclear. Therefore, in this article, we summarized clinical and experimental studies of caloric restriction on depression. This review may provide a new therapeutic strategy for depression.

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Section: Mechanism Of Actionmentioning

confidence: 98%

Effect of caloric restriction on depression

Manchishi

Cui

Zou

et al. 2018

J Cellular Molecular Medi

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“…The same compound inhaled (perillaldehyde 0.0965 and 0.965 mg/mouse/day, days) had antidepressant-like properties on stress-induced depression-like model in mice, during the FST through the olfactory nervous function [92]. The oil of PF seeds might have an anti-depressant activity too: a seed oil-rich diet during a forced swim test in adult male rats modulated the fatty acid profiles and BDNF expression in the brain [93]. Moreover, perilla seed oil rich in n-3 fatty acids-improved cognitive function in rats by generating new hippocampal neural membrane structures as well as by inducing specific protein expression [94].…”

Section: Anti-depressant Activitymentioning

confidence: 99%

Ethnomedicinal, Phytochemical and Pharmacological Investigations of <em>Perilla frutescens</em> (L.) Britt<strong> </strong>

Ahmed

2018

Preprint

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Perilla frutescens (L.) Britt. (PF) is an annual herbal medicinal, aromatic, functional food and ornamental plant that belongs to the mint family, Lamiaceae. The origin of perilla traces back to East Asian countries (China, Japan, Korea, Taiwan, Vietnam and India), where it has been used as a valuable source of culinary and traditional medicinal uses. Leaves, seeds and stems of P. frutescens are used for various therapeutic applications in folk medicine. In the absence of comprehensive review regarding all aspects of perilla, thus this review aims to present an overview pertaining to the botanical drug, ethnobotany, phytochemistry and biological activity. It was found that the taxonomic classification of perilla species is quite confused, and the number of species is vague. Perilla has traditionally been prescribed to treat depression-related disease, anxiety, asthma, chest stuffiness, vomiting, cough, cold, flus, phlegm, tumour, allergy, intoxication, fever, headache, stuffy nose, constipation, abdominal pain, indigestion, analgesic, anti-abortive agent, and sedative. Until now, 271 natural molecules have been identified in perilla organs including; polyphenols, flavonoids, essential oils, triterpenes, carotenoids, phytosterols, fatty acids, tocopherols and policosanols. In addition to solvent extracts, these individual compounds (rosmarinic acid, perillaldehyde, luteolin, apigenin, tormentic acid, isoegomaketone) have attracted researchers' interest for pharmacological properties. Its bioactivity showed antioxidant, antimicrobial, anti-allergic, antidepressant, anti-inflammatory, anticancer, neuroprotection activity. Although the results are promising in preclinical studies (in vitro and in vivo) as well, clinical studies are insufficient, therefore further study needs to be done to validate its therapeutic effects and to ensure its safety and efficacy.

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“…The oil of PF seeds might have an anti-depressant activity too since a seed oil-rich diet during a forced swim test in adult male rats modulated the fatty acid profiles and brain-derived neurotrophic factor (BDNF) expression in the brain [90]. Moreover, perilla seed oil rich in n -3 fatty acids improved cognitive function in rats by generating new hippocampal neural membrane structures as well as by inducing specific protein expression [91].…”

Section: Pharmacological Properties Of Perillamentioning

confidence: 99%

Ethnomedicinal, Phytochemical and Pharmacological Investigations of Perilla frutescens (L.) Britt.

2018

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Perilla frutescens (L.) Britt. (PF) is an annual herbal medicinal, aromatic, functional food, and ornamental plant that belongs to the mint family, Lamiaceae. The origin of perilla traces back to East Asian countries (China, Japan, Korea, Taiwan, Vietnam, and India), where it has been used as a valuable source of culinary and traditional medicinal uses. The leaves, seeds, and stems of P. frutescens are used for various therapeutic applications in folk medicine. In the absence of a comprehensive review regarding all aspects of perilla, this review aims to present an overview pertaining to the botanical drug, ethnobotany, phytochemistry, and biological activity. It was found that the taxonomic classification of perilla species is quite confused, and the number of species is vague. Perilla has traditionally been prescribed to treat depression-related disease, anxiety, asthma, chest stuffiness, vomiting, coughs, colds, flus, phlegm, tumors, allergies, intoxication, fever, headache, stuffy nose, constipation, abdominal pain, and indigestion, and acts as an analgesic, anti-abortive agent, and a sedative. Until now, 271 natural molecules have been identified in perilla organs including phenolic acids, flavonoids, essential oils, triterpenes, carotenoids, phytosterols, fatty acids, tocopherols, and policosanols. In addition to solvent extracts, these individual compounds (rosmarinic acid, perillaldehyde, luteolin, apigenin, tormentic acid, and isoegomaketone) have attracted researchers’ interest for its pharmacological properties. Perilla showed various biological activities such as antioxidant, antimicrobial, anti-allergic, antidepressant, anti-inflammatory, anticancer, and neuroprotection effects. Although the results are promising in preclinical studies (in vitro and in vivo), clinical studies are insufficient; therefore, further study needs to be done to validate its therapeutic effects and to ensure its safety and efficacy.

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Antidepressant-like effects of Perilla frutescens seed oil during a forced swimming test

Cited by 31 publications

References 38 publications

Effect of caloric restriction on depression

Effect of caloric restriction on depression

Ethnomedicinal, Phytochemical and Pharmacological Investigations of <em>Perilla frutescens</em> (L.) Britt<strong> </strong>

Ethnomedicinal, Phytochemical and Pharmacological Investigations of Perilla frutescens (L.) Britt.

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