Antidepressant-like effects of NMDA-receptor antagonist injected into the dorsal hippocampus of rats

The 5-HT6 receptor agonist EMD 386088 produces antidepressant and anxiolytic effects in rats after intrahippocampal administration

“…The hippocampus may mediate the effects of compounds with diverse mechanisms of action in preclinical models of anxiety and depression. For example, the reduced immobility in the forced swim test in rats has been observed after intrahippocampal administration of tricyclic antidepressants, imipramine (Przegalinski et al 1997), and desipramine (Kostowski 1985); 5-HT7 receptor antagonists (Wesolowska et al 2006); ionotropic glutamate receptor antagonist (Padovan and Guimaraes 2004); as well as neurotrophic factors (Shirayama et al 2002). Moreover, the hippocampus mediates the effects of benzodiazepines or a direct GABAA receptor agonist (Menard and Treit 2001;Rezayat et al 2005), serotonin receptor (i.e., 5-HT1A and 5-HT7) ligands (Menard and Treit 1998;Wesolowska et al 2006), an acetylcholinesterase inhibitor (Degroot and Treit 2002), ionotropic or metabotropic glutamate receptor ligands (Padovan et al 2000;Palucha et al 2004), and neurosteroids (Bitran et al 1999) in various models of anxiety, including the conflict drinking test and the elevated plus maze test.…”

Neuropharmacological activity of hydroalcoholic extract of leaves ofColocasia esculenta

“…Male rats were used for this test (Padovan & Guimaraes, 2004;Calil & Marcondes, 2006). Swimming sessions were conducted by placing rats in an individual glass cylinder (35 cm × 25 cm) containing water (25° ± 1°C) 27 cm deep.…”

The Role of Sigma Receptors in Depression

“…The "antidepressant-like" effects of NMDA antagonists likely involve NMDA receptors located in the hippocampus as the NMDA antagonist 2-amino-7-phosphonoheptanoic acid (AP-7), when injected directly into the hippocampus, decreases immobility time in the forced swimming test (FST) (81).…”