Antidepressant-like effects of methanol extract of Hibiscus tiliaceus flowers in mice

Abstract

BackgroundHibiscus tiliaceus L. (Malvaceae) is used in postpartum disorders. Our purpose was to examine the antidepressant, anxiolytic and sedative actions of the methanol extract of H. tiliaceus flowers using animal models.MethodsAdult male Swiss albino mice were treated with saline, standard drugs or methanol extract of H. tiliaceus and then subjected to behavioral tests. The forced swimming and tail suspension tests were used as predictive animal models of antidepressant activity, where the time of immobility was considered. The animals were submitted to the elevated plus-maze and ketamine-induced sleeping time to assess anxiolytic and sedative activities, respectively.ResultsMethanol extract of H. tiliaceus significantly decreased the duration of immobility in both animal models of antidepressant activity, forced swimming and tail suspension tests. This extract did not potentiate the effect of ketamine-induced hypnosis, as determined by the time to onset and duration of sleeping time.ConclusionOur results indicate an antidepressant-like profile of action for the extract of Hibiscus tiliaceus without sedative side effect.

Anti-depressant and anxiolytic potential of Acacia hydaspica R. Parker aerial parts extract: Modulation of brain antioxidant enzyme status

“…There is ample scientific and empirical evidence supporting the use of antioxidants for the control or slowing down progression of neurodegenerative disorders [ 45 ]. Plant extracts treatment that possesses antioxidant capacity also potentiate antidepressant potentials in in vivo studies [ 46 , 47 ]. Function of flavonoids with antidepressant and anxiolytic potential has been established in many plants in traditional [ 48 ].…”

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“…Recently oxidative stress was linked with psychophysiology of major depressives with correlation between severity of depression and erythrocyte superoxidase dismutase, lipid peroxidation levels. Literature survey shows that treatment with antidepressants reduces the oxidative stress related to depressive disorders 24 . Therefore it is possible that the antioxidant activity of aqueous and ethanolic leaf and stem bark extracts of L. floribunda may contribute to its antidepressant like effects.…”

Cadinane-Type Sesquiterpenoids with Cytotoxic Activity from the Infected Stems of the Semi-mangrove Hibiscus tiliaceus

“…2,3 Hibiscus tileaceus L. is a semi-mangrove plant belonging to the family Malvaceae and is distributed widely in tropical and subtropical regions, including southern mainland China, India, Bangladesh, Vietnam, the Philippines, subtropical America, Africa, and Australia, and throughout the Pacific islands. 4,5 In addition to being an ornamental tree, H. tiliaceus has been used as a medicinal plant worldwide. In China, it is used traditionally as a folk medicine for heat-clearing and detoxifying and as a stasis-dissipating and detumescence agent.…”