Antidepressant-like effects of aqueous extract from Cecropia pachystachya leaves in a mouse model of chronic unpredictable stress

LC/QTOF profile and preliminary stability studies of an enriched flavonoid fraction of Cecropia pachystachya Trécul leaves with potential antidepressant‐like activity

“…However, our results did not show any alterations on SOD and CAT activity for all treatments in all brain structures. In accordance with our study, Gazal et al () demonstrated that chronic treatment with the aqueous extract of C. pachystachya reversed the increase in TBARS levels in the hippocampus of rats subjected to chronic mild stress, without changing the CAT and SOD activities. Moreover, the hydroethanolic extract of another Cecropia species, C. glaziovii Sneth, inhibited lipid peroxidation on the liver in post‐injury treatment and enhanced the activity of hepatic enzymes (SOD/CAT) (Petronilho et al, ).…”

“…Studies have shown that C. pachystachya has anti‐inflammatory, cardiotonic, sedative and antioxidant properties (Aragão et al, ; Consolini, Ragone, Migliori, Conforti, & Volonté, ; Hikawczuk, Saad, Guardia, Juarez, & Giordano, ). We have been determining the potential of C. pachystachya in the central nervous system as an antidepressant‐like agent, by studying the effect of the crude extract at 200 and 400 mg/kg in mice submitted to chronic unpredictable stress (Gazal et al, ) and of EFF‐ Cp at 50 and 100 mg/kg in rats subjected to chronic mild stress (Ortmann et al, ). In fact, the achievement of an enriched flavonoid fraction allowed a reduction in the active dose, at four times, assigning technological advantages.…”

“…To confirm if the EFF-Cp analyzed by LC/QTOF has antidepressant activity, as previously described (Ortmann et al, 2016), Studies have shown that C. pachystachya has anti-inflammatory, cardiotonic, sedative and antioxidant properties (Aragão et al, 2013;Consolini, Ragone, Migliori, Conforti, & Volonté, 2006;Hikawczuk, Saad, Guardia, Juarez, & Giordano, 1998). We have been determining the potential of C. pachystachya in the central nervous system as an antidepressant-like agent, by studying the effect of the crude extract at 200 and 400 mg/kg in mice submitted to chronic unpredictable stress (Gazal et al, 2014) and of EFF-Cp at 50 and 100 mg/kg in rats subjected to chronic mild stress (Ortmann et al, 2016). In fact, the The flavonoid activities in the central nervous system have been previously reported in the literature (Grosso, Valentão, Ferreres, & Andrade, 2013).…”

Differentiation of the phenolic chemical profiles ofCecropia pachystachyaandCecropia hololeuca

“…These studies have indicated a phenolic‐rich profile, which includes C ‐glycosylated flavonoids, such as orientin, isoorientin, vitexin and isovitexin, in addition to chlorogenic acid. These constituents have been related to biological properties, such as anti‐inflammatory, leishmanicidal, and hypoglycemic activities, among others . Cecropia hololeuca possesses silver leaves, and because of this, is popularly known in Brazil as silver embaúba .…”

Panax Notoginseng Saponins: A Review of Its Mechanisms of Antidepressant or Anxiolytic Effects and Network Analysis on Phytochemistry and Pharmacology

“…Modern pharmacological studies have found Panax notoginseng saponins (PNS) have a good preventive and therapeutic effects of brain neurological diseases [26,28,57]. Ginsenosides Rg1, Rb1, Re and notoginsenoside R1, as the representative [26,28,57], showed anti-depressant and anti-anxiety activity [28,31,35,[58][59][60][61].The evaluation methods of antidepressant effects include sucrose preference test (SPF) [62], forced swimming test (FST) [63][64][65] , open field test (OFT) [62,64,66], elevated plus-maze (EPM) test and tail suspension test [66].…”