Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress

Zhu, Yimin; Wang, Linyuan; Zhao, Dan-Ping; Wang, Chenglong; Zhang, Rui; Fei, Wenting; Wang, Jingxia; Zhang, Jianjun

doi:10.1016/s1875-5364(20)60030-9

Cited by 8 publications

(5 citation statements)

References 37 publications

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“…Tryptophan is also the precursor of serotonin (5-HT). The abnormal metabolism of tryptophan causes the abnormal metabolism of 5-HT neurotransmitters, manifested as insufficient synthesis and transmission disorder, and is closely related to the pathogenesis of depression (73), which is consistent with the previous research results of our research group (16). In this experiment, the content of kynurenine in the model rats decreased, indicating that the rats showed depression-like behavior and abnormal tryptophan metabolism.…”

Section: Discussionsupporting

confidence: 90%

“…With the exception of those from the control and model group, rats were intragastrically (i.g.) pretreated with the Paeoniae Radix Alba (2 g/kg), PF (30 mg/kg), and AF (30 mg/kg) for 21 days according to the previous study (16)(17)(18). The rats, with the exception of the normal group, were individually housed and received chronic restraint stress in the form of restricted movement for 3 h (8:00 a.m.−11:00 a.m.) for 21 days.…”

Section: Animal Experimentsmentioning

confidence: 99%

“…Simultaneously, there are reports in the literature regarding the anticancer activities of PRA (13), and its major active constituents, paeoniflorin (PF) (14), and total glucosides of paeony (TGP) (15). However, few anticancer studies regarding albiflorin (AF), a monoterpene glycoside that is isomeric with PF (16), have been reported, which may be related to the difficulty found in its isolation and purification. The good news here is that our team has successfully isolated and purified AF and PF with high purity, and the method has also been obtained a Chinese patent certificate (ZL 201110184287.4).…”

Section: Introductionmentioning

confidence: 99%

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Study of Antidepressant-Like Effects of Albiflorin and Paeoniflorin Through Metabolomics From the Perspective of Cancer-Related Depression

et al. 2022

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Mental health has become a new challenge in cancer treatment, with a high prevalence of depression in patients with cancer. Albiflorin (AF) and paeoniflorinn (PF) are isomers extracted from the root of Paeoniae Radix Alba (Baishao in Chinese), belonging to the monoterpene glycosides, and multiple studies have been conducted on their antidepression and anti-cancer effects. However, the effects of AF and PF on cancer-related depression are unclear. Therefore, the current study aims to investigate whether the two isomers are able to exert antidepressant-like effects and understand the underlying mechanisms in a rat model, established by combining irradiation with chronic restraint stress and solitary confinement. Our results demonstrate a significant regulation of AF and PF in the pharmacodynamic index, including the peripheral blood, organ index, behavioral traits, and HPA axis, relative to control rats. In serum and cerebral cortex metabonomics analysis, AF and PF showed a significantly restorative trend in abnormal biomarkers and regulating ether lipid metabolism, alanine, aspartate, glutamate metabolism, tryptophan metabolism, carnitine metabolism, arachidonic acid metabolism, arginine and proline metabolism pathway. Eight potential biomarkers were further screened by means of receiver operating characteristic (ROC) analysis. The data indicate that AF and PF could effectively ameliorate a depression-like state in the model rats, and the mechanism may be associated with the regulation of the neuroendocrine immune system and disrupted metabolic pathways. Further experiments are warranted to comprehensively evaluate the antidepressant effects of AF and PF in cancer-related depression. This study provides a better insight into the action mechanisms of antidepression of TCM, and provides a new perspective for the therapy of cancer-related depression.

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Section: Discussionsupporting

confidence: 90%

Section: Animal Experimentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Study of Antidepressant-Like Effects of Albiflorin and Paeoniflorin Through Metabolomics From the Perspective of Cancer-Related Depression

et al. 2022

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“…Albiflorin produces significant antidepressant-like effects by increasing the levels of 5-HT, 5-hydroxyindoleacetic acid (5-HIAA, one metabolite of 5-HT) and BDNF expression in hippocampus of CUS-induced depressive rats 49 . Albiflorin also shows antidepressant-like effects by increasing the levels of 5-HT and 5-HIAA in hippocampus, and increasing the levels of BDNF in serum and protein expression in hippocampus of CRS-induced rats 50 . It also produces rapid antidepressant-like effects by regulating hippocampal phospholipid and tryptophan metabolism in CUMS, olfactory bulbectomy and LPS-induced murine models of depression 51 .…”

Section: Discussionmentioning

confidence: 91%

“…Quercetin alleviates depressive-like behaviours in different animal models, like stress-induced male mice 45 , lipopolysaccharide (LPS)-induced male rats 46 , CUMS-induced male mice 47 and oestrogen receptor α-deficient-induced female mice 48 . Albiflorin produces significant antidepressant-like effects in chronic unpredictable stress (CUS)-induced depressive rats 49 and chronic restraint stress (CRS)-induced rats 50 . Albiflorin also shows rapid antidepressant-like effects in CUMS, olfactory bulbectomy and LPS-induced murine models of depression 51 .…”

Section: Discussionmentioning

confidence: 99%

Exploring the mechanism of Si-Ni-San against depression by UPLC-Q-TOF-MS/MS integrated with network pharmacology: experimental research

Jia,

Li,

et al. 2023

Annals of Medicine &Amp; Surgery

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Background: Depression is becoming an urgent mental health problem. Si-Ni-San has been widely used to treat depression, yet its underlying pharmacological mechanism is poorly understood. Thus, we aim to explore the antidepressant mechanism of Si-Ni-San by chemical analysis and in silico methods. Methods: Compounds in Si-Ni-San were determined by ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS). Then, bioactive compounds were obtained from TCMSP and SwissADME, and the potential targets of which were acquired from SwissTargetPrediction. Depression-related targets were collected from GeneCards. The intersection between compound-related targets and depression-related targets were screened out, and the overlapped targets were further performed protein-protein interaction, biological functional and pathway enrichment analysis. Finally, networks of Si-Ni-San against depression were constructed and visualized by Cytoscape. Results: 119 compounds in Si-Ni-San were determined, of which 24 bioactive compounds were obtained. Then, 137 overlapped targets of Si-Ni-San against depression were collected. AKT1, PIK3R1, PIK3CA, mTOR, MAPK1 and MAPK8 were the key targets. Furthermore, PI3K-Akt signaling pathway, serotonergic synapse, MAPK signaling pathway and neurotrophin signaling pathway were involved in the antidepressant mechanism of Si-Ni-San. It showed that components like sinensetin, hesperetin, liquiritigenin, naringenin, quercetin, albiflorin and paeoniflorin were the mainly key active compounds for the antidepressant effect of Si-Ni-San. Conclusions: This study demonstrated the key components, key targets and potential pharmacological mechanisms of Si-Ni-San against depression. These results indicate that Si-Ni-San is a promising therapeutic approach for treatment of depression, and may provide evidence for the research and development of drugs for treating depression.

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Paeoniae Radix Rubra: A Review of Ethnopharmacology, Phytochemistry, Pharmacological Activities, Therapeutic Mechanism for Blood Stasis Syndrome, and Quality Control

Fan,

Liu,

Wang

et al. 2024

Chemistry & Biodiversity

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Paeoniae Radix Rubra (PRR) known as Chishao, in China, is the dried root of Paeonia lactiflora Pall. or Paeonia veitchii Lynch, with a history of over 2000 years in traditional Chinese medicine, is employed to clear heat, cool the blood, dispel blood stasis, and alleviate pain. Phytochemical investigations identified 264 compounds that contained monoterpenes and their glycosides, sesquiterpenes, triterpenes, steroids, flavonoids, lignans, tannins, volatile oils, and other compounds. It has been reported to have different pharmacological activities, including cardiovascular‐protective, antidepressive, neuroprotective, antitumor, hepatoprotective, and anti‐inflammatory effects. This study offers a comprehensive review covering ethnopharmacology, phytochemistry, pharmacological activities, therapeutic mechanism for blood stasis syndrome, and quality control of PRR. The comprehensive analysis aims to achieve a thorough understanding of its effects and serves as a foundation for future research and development.

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Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress

Cited by 8 publications

References 37 publications

Study of Antidepressant-Like Effects of Albiflorin and Paeoniflorin Through Metabolomics From the Perspective of Cancer-Related Depression

Study of Antidepressant-Like Effects of Albiflorin and Paeoniflorin Through Metabolomics From the Perspective of Cancer-Related Depression

Exploring the mechanism of Si-Ni-San against depression by UPLC-Q-TOF-MS/MS integrated with network pharmacology: experimental research

Paeoniae Radix Rubra: A Review of Ethnopharmacology, Phytochemistry, Pharmacological Activities, Therapeutic Mechanism for Blood Stasis Syndrome, and Quality Control

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