Antidepressant–like effects of Acorus calamus in forced swimming and tail suspension test in mice

Pawar, Vinod S; Anup, Akhade; Shrikrishna, Baokar; Hugar, Shivakumar

doi:10.1016/s2221-1691(11)60114-7

Cited by 18 publications

(9 citation statements)

References 10 publications

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“…In recent years, many traditional Chinese medicinal plants such as Acanthopanax senticosus [ 7 ], Acorus calamus [ 8 ], Albizia julibrissin [ 9 ], Ginkgo biloba [ 10 ], Paeonia lactiflora [ 11 ], and Hypericum perforatum [ 12 ] have been successfully used to prevent or treat anxiety and depression. Thus, traditional Chinese medicines may be effective alternatives for the treatment of psychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Anxiolytic and Antidepressant Activities of the Aqueous Extract fromCamellia euphlebiaMerr. ex Sealy in Mice

Wang

Zhang

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Camellia euphlebia Merr. ex Sealy is a traditional Chinese medicine that has been widely used for improvement of human emotions in the Guangxi Province of southern China. However, there are no studies about the anxiolytic and antidepressant activities of Camellia euphlebia. This study evaluated the anxiolytic and antidepressant activities of the aqueous extract from Camellia euphlebia (CEE) in mice. We found that administration of 400 mg/kg CEE or 20 mg/kg fluoxetine for 7 days significantly reduced the immobility time in both TST and FST. Oral administration of 100 mg/kg extract or 4 mg/kg diazepam for 7 days significantly increased the percentage of time spent and the number of entries into the open arms of the EPMT. In addition, the time spent by mice in the illuminated side of the LDBT was increased. Furthermore, pretreatment with 400 mg/kg CEE for 7 days significantly elevated the level of 5-HT and DA in the whole brain of mice. These results provide support for the potential anxiolytic and antidepressant activity of Camellia euphlebia and contribute towards validation of the traditional use of Camellia euphlebia in the treatment of emotional disorders.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Anxiolytic and Antidepressant Activities of the Aqueous Extract fromCamellia euphlebiaMerr. ex Sealy in Mice

Wang

Zhang

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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“…To date, one xanthone glycoside (123) [82,83], two alkaloids (126)(127) [84], one triterpene glycoside (128), one steroid (129) [85], 12 amino acids (130-141) [86,87], and 4 fatty acids (142)(143)(144)(145) [88] have been identified in A. calamus rhizomes [83][84][85][86][87][88].…”

Section: Other Compoundsmentioning

confidence: 99%

“…Interaction of the methanolic A. calamus rhizome extract with the adrenergic, dopaminergic, serotonergic, and GABAergic system was found responsible for the expression of antidepressant activity [128]. In another study, the methanolic A. calamus leave extract showed significant activity through a reduction in the immobility period in the TST and FST [129].…”

Section: Antidepressant Effectmentioning

confidence: 99%

Role of Vacha (Acorus calamus Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study

Sharma

Gautam

et al. 2020

JCM

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Vacha (Acorus calamus Linn. (Acoraceae)) is a traditional Indian medicinal herb, which is practiced to treat a wide range of health ailments, including neurological, gastrointestinal, respiratory, metabolic, kidney, and liver disorders. The purpose of this paper is to provide a comprehensive up-to-date report on its ethnomedicinal use, phytochemistry, and pharmacotherapeutic potential, while identifying potential areas for further research. To date, 145 constituents have been isolated from this herb and identified, including phenylpropanoids, sesquiterpenoids, and monoterpenes. Compelling evidence is suggestive of the biopotential of its various extracts and active constituents in several metabolic and neurological disorders, such as anticonvulsant, antidepressant, antihypertensive, anti-inflammatory, immunomodulatory, neuroprotective, cardioprotective, and anti-obesity effects. The present extensive literature survey is expected to provide insights into the involvement of several signaling pathways and oxidative mechanisms that can mitigate oxidative stress, and other indirect mechanisms modulated by active biomolecules of A. calamus to improve neurological and metabolic disorders.

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“…The total duration of immobility was measured during a 5-min test. An animal was judged to be immobile when it ceased struggling and remained floating motionless in water, making only those movements as were necessary to keep its head above water (Vogel 2002;Pawar et al 2012).…”

Section: Antidepressant Activitymentioning

confidence: 99%

“…The duration of immobility was recorded for a period of 5 min. The mice were considered immobile when they did not show any body movement, hung passively and completely motionless for at least 1 min (Vogel 2002;Pawar et al 2012).…”

Section: Antidepressant Activitymentioning

confidence: 99%

Bioactive non-sterol triterpenoid fromStreblus asper: microwave-assisted extraction, HPTLC profiling, computational studies and neuro-pharmacological evaluation in BALB/c mice

Verma

Tripathi

Saraf

2016

Pharmaceutical Biology

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Context: In folk medicine, the stem bark of Streblus asper Lour. (Moraceae) has been reported to possess anticonvulsant activity. However, no systematic/scientific validation is available. Objective This study explores the constituents in the stem bark, their biosassy-guided isolation and their efficacy in neuro-pharmacological disorders, for validating the traditional claims. Materials and methods: Microwave-assisted extraction (MAE) technique was employed to obtain the crude extract. The n-hexane, dichloromethane and aqueous fractions were prepared and phytoconstituents were ascertained by phytochemical tests. The isolated compound, betulin, was characterized by different physicochemical and spectral methods, including HPTLC. Finally, neuro-pharmacological evaluations were conducted at 100, 200, 400 mg/kg b.w., p.o. (25, 50, 100 mg/kg b.w. for betulin) doses in BALB/c mice. Results: The n-hexane fraction (400 mg/kg), and isolated compound betulin (100 mg/kg), showed maximum anticonvulsant activity in maximal electroshock (87.84% and 85.14% seizure inhibition), and isoniazid induced convulsion models (88.85% and 83.18% seizure inhibition), respectively. A dose-dependent attenuation of epileptic seizures was observed, probably through GABArgic mechanism of anticonvulsant action. Moreover, the antidepressant study was also conducted using behavioural models and the results expound that n-hexane and dichloromethane fractions (400 mg/kg) significantly reduced the duration of immobility, as compared to the control. Discussion and conclusion: This study reports some novel aspects like applying an environmentally benign/green approach of MAE, neuro-pharmacological screening and use of docking studies, for the first time, on the plant S. asper. The findings present a rational explanation for its use in traditional medicine, for the management of neuro-pharmacological disorders.ARTICLE HISTORY

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Antidepressant–like effects of Acorus calamus in forced swimming and tail suspension test in mice

Cited by 18 publications

References 10 publications

Evaluation of the Anxiolytic and Antidepressant Activities of the Aqueous Extract fromCamellia euphlebiaMerr. ex Sealy in Mice

Evaluation of the Anxiolytic and Antidepressant Activities of the Aqueous Extract fromCamellia euphlebiaMerr. ex Sealy in Mice

Role of Vacha (Acorus calamus Linn.) in Neurological and Metabolic Disorders: Evidence from Ethnopharmacology, Phytochemistry, Pharmacology and Clinical Study

Bioactive non-sterol triterpenoid fromStreblus asper: microwave-assisted extraction, HPTLC profiling, computational studies and neuro-pharmacological evaluation in BALB/c mice

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