Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: Involvement of the monoaminergic system

Machado, Daniele G.; Bettio, Luis E.B.; Cunha, Maurício P.; Capra, Juliano C.; Dalmarco, Juliana Bastos; Pizzolatti, Moacir Geraldo; Rodrigues, Ana Lúcia S.

doi:10.1016/j.pnpbp.2009.03.004

Cited by 159 publications

(103 citation statements)

References 69 publications

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“…The other pathway related to the development of depression is neurotransmitter levels and ratios in the brain. [27][28][29][30] The FST trial significantly increased the metabolite/transmitter ratio (DOPAC/DA and 5-HIAA/5-HT) (Fig. 3).…”

Section: Discussionmentioning

confidence: 96%

Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress

Kageyama

Sakakibara

Zhou

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 96%

Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress

Kageyama

Sakakibara

Zhou

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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“…These tests are sensitive to the major classes of the clinical antidepressants (Porsolt et al, 1977;Steru et al, 1985;Detke et al, 1995;Cryan et al, 2005;Petit-Demouliere et al, 2005). Moreover, there is a significant correlation between the pharmacological antidepressant activity and clinical potency in both models for the tested agent (Machado et al, 2009). Therefore, we chose FST and TST to evaluate the putative antidepressant effect of ZZHPD.…”

Section: Discussionmentioning

confidence: 99%

Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: Restoration of monoamine neurotransmitters in discrete brain regions

Aimin¹,

Ma²,

Zhang³

et al. 2012

Pharmaceutical Biology

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“…Immobility time was recorded during a 6-min period. Mice were considered immobile only when they hung passively and completely motionless [16,39,42].…”

Section: Tail Suspension Test (Tst)mentioning

confidence: 99%

“…To assess the possible effects of drugs on locomotor activity, mice were evaluated in the open-field paradigm as previously described [18,42]. Mice were individually placed in a wooden box (40×60×50 cm) with the floor divided into 12 equal rectangles.…”

Section: Open-field Testmentioning

confidence: 99%

Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation

Cunha

Pazini

Rosa

et al. 2015

Purinergic Signalling

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The benefits of creatine supplementation have been reported in a broad range of central nervous systems diseases, including depression. A previous study from our group demonstrated that creatine produces an antidepressant-like effect in the tail suspension test (TST), a predictive model of antidepressant activity. Since depression is associated with a dysfunction of the adenosinergic system, we investigated the involvement of adenosine A 1 and A 2A receptors in the antidepressant-like effect of creatine in the TST. The anti-immobility effect of creatine (1 mg/kg, po) or ketamine (a fast-acting antidepressant, 1 mg/kg, ip) in the TST was prevented by pretreatment of mice with caffeine (3 mg/kg, ip, nonselective adenosine receptor antagonist), 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) (2 mg/kg, ip, selective adenosine A 1 receptor antagonist), and 4-(2-[7-amino-2-{2-furyl}{1,2,4}triazolo-{2,3-a}{1,3,5}triazin-5-ylamino]ethyl)-phenol (ZM241385) (1 mg/kg, ip, selective adenosine A 2A receptor antagonist). In addition, the combined administration of subeffective doses of creatine and adenosine (0.1 mg/kg, ip, nonselective adenosine receptor agonist) or inosine (0.1 mg/kg, ip, nucleoside formed by the breakdown of adenosine) reduced immobility time in the TST. Moreover, the administration of subeffective doses of creatine or ketamine combined with N-6-cyclohexyladenosine (CHA) (0.05 mg/kg, ip, selective adenosine A 1 receptor agonist), N-6-[2-(3,5-dimethoxyphenyl)-2-(methylphenyl)ethyl]adenosine (DPMA) (0.1 mg/kg, ip, selective adenosine A 2A receptor agonist), or dipyridamole (0.1 μg/mouse, icv, adenosine transporter inhibitor) produced a synergistic antidepressant-like effect in the TST. These results indicate that creatine, similarly to ketamine, exhibits antidepressant-like effect in the TST probably mediated by the activation of both adenosine A 1 and A 2A receptors, further reinforcing the potential of targeting the purinergic system to the management of mood disorders.

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Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: Involvement of the monoaminergic system

Cited by 159 publications

References 69 publications

Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress

Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress

Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: Restoration of monoamine neurotransmitters in discrete brain regions

Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A1 and A2A receptor activation

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