Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: Evidence for the involvement of the serotonergic and noradrenergic systems

Machado, Daniele G.; Bettio, Luis E.B.; Cunha, Maurício P.; Santos, Adair R.S.; Pizzolatti, Moacir Geraldo; Brighente, Inês Maria Costa; Rodrigues, Ana Lúcia S.

doi:10.1016/j.ejphar.2008.03.021

Cited by 176 publications

(125 citation statements)

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“…We then studied the possible anti-stress activity of quercetin, isoquercitrin or rutin that we isolated from H. connatum. A significant protective activity in the ED test was observed with isoquercitrin, quercetin and rutin, in agreement with the results obtained in different tests for antidepressant-like activity after acute (Butterweck et al 2000;Machado et al 2008;Kawabata et al 2010) or repeated administrations (Rinwa and Kumar 2013;Holzmann et al 2015). These results indicate that the protective effects on stress exposure observed after the administration of the extract or its flavonoid-enriched fractions were related to the presence of these flavonoids, suggesting that the active principles responsible of H. connatum central activity are likely different from those involved in the antidepressant effects of H. perforatum.…”

Section: Discussionsupporting

confidence: 78%

“…(stress) and five rats received isoquercitrin (2.5 mg/kg) 60 min before the unavoidable stress session and were tested for escape on the following day. Doses of quercetin, rutin and isoquercitrin were selected based on the published results (Butterweck et al 2000;Machado et al 2008;Kawabata et al 2010). …”

Section: Effect Of Single Administration Of Fractions Of H Connatum mentioning

confidence: 99%

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The protective effect of Hypericum connatum on stress-induced escape deficit in rat is related to its flavonoid content

Scheggi

Marandino

Monte

et al. 2016

Pharmaceutical Biology

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De Feo (2016) The protective effect of Hypericumconnatum on stress-induced escape deficit in rat is related to its flavonoid content, Pharmaceutical Biology, 54:9, 1782-1792, DOI: 10.3109/13880209.2015 Objective This study evaluates the antidepressant-like effect of H. connatum in rats and identifies the components involved in this activity. Materials and methods First, the effects of acute and 14-d oral administrations of an extract derived from H. connatum aerial parts were studied using the Escape Deficit (ED) test. Next, methanol-extracted flavonoid-enriched fractions B and C and fraction-purified flavonoids (quercetin, rutin and isoquercitrin) were evaluated in the ED test after acute administration. To rule out possible confounding effects of the flavonoids, we examined nociceptive threshold using the tailflick test and anxious behaviour using the elevated plus maze (EPM) test. Results Hypericum connatum increased reactivity of unavoidable stress-exposed rats after acute

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Section: Discussionsupporting

confidence: 78%

Section: Effect Of Single Administration Of Fractions Of H Connatum mentioning

confidence: 99%

The protective effect of Hypericum connatum on stress-induced escape deficit in rat is related to its flavonoid content

Scheggi

Marandino

Monte

et al. 2016

Pharmaceutical Biology

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“…O gênero Schinus L. pertence à família Anacardiaceae e contém 37 espécies presentes, desde a América Central até a Argentina (MACHADO et al, 2008). A espécie Schinus molle é conhecida, popularmente, como aroeira salsa ou aroeirinha, apresentando hábito arbóreo com cerca de 8-20 m com copa globosa, densa, perenifólia, com folhas compostas, pinatífidas.…”

Section: Introductionunclassified

MICROMORFOMETRIA FOLIAR DE Schinus molle L. (ANARCADIACEAE) EM DIFERENTES ALTURAS NA COPA

Pires

Pereira

Castro

et al. 2015

CERNE

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MICROMORFOMETRIA FOLIAR DE Schinus molle L. (ANARCADIACEAE) EM DIFERENTES ALTURAS NA COPARESUMO: A caracterização foliar em árvores é essencial para a sua identificação e utilização, bem como para se compreender as suas relações com o ambiente. Neste trabalho, objetivou-se o estudo da anatomia dos folíolos e das características biométricas das folhas de S. molle em diferentes alturas na copa, em função das modificações ambientais e fisiológicas promovidas. As folhas foram coletadas em três diferentes alturas na copa: base, meio e alto da copa em uma população cultivada de S. molle. Para as analises anatômicas, as folhas foram fixadas em FAA e armazenadas em etanol sendo, posteriormente, submetidas a secções paradérmicas e transversais. As lâminas foram fotomicrografadas e as imagens analisadas no software UTHSCSA-Imagetool. Para as análises biométricas foram avaliadas a área, comprimento, largura, massa seca foliares, bem como a área foliar específica. Os folíolos possuem epiderme unisseriada, estômatos anomocíticos e ciclocíticos, mesofilo isobilateral e camada subepidérmica em ambas as faces da epiderme. Canais secretores e colênquima foram observados na nervura central e bordo dos folíolos. Ocorreram modificações nas espessuras da cutícula e do mesofilo, no sistema vascular, espessura do floema e na densidade estomática de acordo com a altura em que os folíolos se encontram na copa das árvores. As folhas foram menores e demonstram reduzida área foliar para as partes mais altas da copa. A anatomia foliar de S. molle é diferente de outras espécies do gênero Schinus e demonstra modificações sob as diferentes condições ambientais e fisiológicas promovidas pelas diferentes alturas na copa. LEAF MICROMORPHOMETRY OF Schinus molle L. (ANARCADIACEAE) IN DIFFERENT CANOPY HEIGHTS.ABSTRACT: Leaf characterization of trees is essential for its identification and use, as well as to understand its relationships with environment. The objective of this work is to study the leaflet anatomy and leaf biometrical characteristics at different canopy heights of Schinus molle plants as a function of its environmental and physiological modifications. Leaves were collected at three different canopy heights: base, middle and upper canopy in a plantation of S. molle. Leaves were used for anatomical and biometrical analysis. For the anatomical analysis, leaves were fixed in FAA and stored in ethanol 70% and further submitted to transversal and paradermical sections. Slides were photomicrographed and image analysis was performed in UTHSCSA-Imagetool. For biometrical analysis leaf area, length, width, dry mass and specific leaf area were evaluated. The leaflets exhibited single layer epidermis, anomocytic and ciclocytic stomata, isobilateral mesophyll, subepidermal parenchyma layer in both adaxial and abaxial faces of epidermis, secretory vessels and lamellar collenchyma in midrib and leaf border. Leaf anatomy modifications occurred in cuticle and mesophyll thickness, vascular system, phloem thickness, and stomatal density in accordance wit...

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“…This was done in order to check the fitness level of each animal and to obtain a stable immobility time profile [30]. In the second session (24 h after the pre-test), the rats were allowed to swim for 5 min following treatment (60 min, 4 h and 24 h before the test) and the total duration of immobility was recorded using a stopwatch [31,32]. The rats were judged to be immobile when they remained floating without struggling, and making movements necessary only to keep their heads above the water.…”

Section: Forced Swim Testmentioning

confidence: 99%

Evaluation of the Antidepressant-like Activity of the Crude Extract and Solvent Fractions of Rosa Abyssinica Lindley (Rosaceae) Using Rodent Models of Depression

Fekadu¹,

Shibeshi²,

Engidawork³

2016

Clin Exp Pharmacol

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Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: Evidence for the involvement of the serotonergic and noradrenergic systems

Cited by 176 publications

References 38 publications

The protective effect of Hypericum connatum on stress-induced escape deficit in rat is related to its flavonoid content

The protective effect of Hypericum connatum on stress-induced escape deficit in rat is related to its flavonoid content

MICROMORFOMETRIA FOLIAR DE Schinus molle L. (ANARCADIACEAE) EM DIFERENTES ALTURAS NA COPA

Evaluation of the Antidepressant-like Activity of the Crude Extract and Solvent Fractions of Rosa Abyssinica Lindley (Rosaceae) Using Rodent Models of Depression

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