Antidepressant-like effect of resveratrol: Involvement of antioxidant effect and peripheral regulation on HPA axis

Ge, Jin‐Fang; Peng, Lei; Cheng, Jiang-Qun; Pan, Chunxiao; Tang, Jie; Chen, Feihu; Li, Jun

doi:10.1016/j.pbb.2013.10.028

Cited by 48 publications

(42 citation statements)

References 39 publications

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“…In terms of human beings, chronic treatment of RES with the dose ranging from 200 mg [20] to 1000 mg [50] daily was used in clinical trials and demonstrated well tolerated [51]. Consistent with our previous study which demonstrated the anti-depressant effect of RES [52], the dose of 15 mg/kg was selected in the present study, and our results showed its ameliorative effect on the spatial learning and memory ability in a SCH rat…”

Section: Acknowledgmentssupporting

confidence: 76%

Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization

et al. 2015

Endocr J

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Section: Acknowledgmentssupporting

confidence: 76%

Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization

et al. 2015

Endocr J

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“…In this regard it would be of considerable interest to investigate possible interactions between the inflammatory and neurotrophic factors, particularly following long-term resveratrol treatment. Moreover, the established antioxidant effects of resveratrol as well as its interaction with the hypothalamic-pituitary axis [29] may be also contributing to its mood regulating effects. A further advantage of resveratrol may involve its prevention of cognitive decline that might also be associated with chronic unpredictable mild stress [30].…”

Section: Discussionmentioning

confidence: 99%

Antidepressant effects of resveratrol in an animal model of depression

Hurley

Akinfiresoye

Kalejaiye

et al. 2014

Behavioural Brain Research

142

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Resveratrol (3,4’,5-trihydroxy-trans-stilbene) is a natural non-flavonoid polyphenol antioxidant extracted from red grapes in the processing of wine. Initially it was studied for its potential as anticancer drug, and later was found to reduce cardiovascular disease. More recently resveratrol was shown to alleviate depressive-like symptoms induced by stress or other means in mice and rats. The major purpose of this study was to investigate whether resveratrol would manifest an antidepressant effect in Wistar-Kyoto (WKY) rats, a putative and non-induced animal model of depression, and whether this effect might be associated with an increase in hippocampal and frontal cortical brain-derived neurotrophic factor (BDNF), a protein implicated in chronic effects of many antidepressants. Adult male WKY rats were injected with two doses of resveratrol (10 and 40 mg/kg, i.p.) and their behavior in the open field locomotor activity (LMA), forced swim test (FST: a measure of helplessness), and sucrose preference test (SPT: a measure of anhedonia) was evaluated after a single acute injection or following 7 days of daily treatment. Both acute and chronic administration of resveratrol resulted in a dose-dependent decrease in FST. However, only chronic resveratrol resulted in dose-dependent increase in sucrose consumption. LMA was not affected by any treatment. Parallel to the observed behavioral effects the level of hippocampal, but not frontal cortical, BDNF was also dose-dependently elevated after chronic resveratrol administration. These findings indicate an antidepressant-like effect of resveratrol in an animal model of depression possibly via activation of hippocampal BDNF, and suggest therapeutic potential of resveratrol in at least a subpopulation of depressed patients.

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“…RSV reduced the upregulated serum concentration of corticosterone, which is known to increase during stress in chronically stressed-rats [267,270],as well as decreased serum corticoterone in unstressed mice [269].…”

Section: Effect Of Rsv On Depressionmentioning

confidence: 95%

“…RSV treatment improved the helplessness symptom as judged by reducing the duration of immobility in the tail suspension or forced swimming tests in rats [264] and mice [265,266]. Also, under chronic stress conditions, an increase in immobility time in both forced swim and tail suspension tests [267], a decrease in sucrose preference [268], the learned helplessness using the shuttle box method [268], and an increase in adrenal gland/body weight [268], were reversed by RSV treatment in rats.…”

Section: Effect Of Rsv On Depressionmentioning

confidence: 97%

The pharmacology of resveratrol in animals and humans

Park

Pezzuto

2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

242

193

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In addition to thousands of research papers related to resveratrol (RSV), approximately 300 review articles have been published. Earlier research tended to focus on pharmacological activities of RSV related to cardiovascular systems, inflammation, and carcinogenesis/cancer development. More recently, the horizon has been broadened by exploring the potential effect of RSV on the aging process, diabetes, neurological dysfunction, etc. Herein, we primarily focus on the in vivo pharmacological effects of RSV reported over the past 5 years (2009-2014). In addition, recent clinical intervention studies performed with resveratrol are summarized. Some discrepancies exist between in vivo studies with animals and clinical studies, or between clinical studies, which are likely due to disparate doses of RSV, experimental settings, and subject variation. Nevertheless, many positive indications have been reported with mammals, so it is reasonable to advocate for the conduct of more definitive clinical studies. Since the safety profile is pristine, an added advantage is the use of RSV as a dietary supplement. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.

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Antidepressant-like effect of resveratrol: Involvement of antioxidant effect and peripheral regulation on HPA axis

Cited by 48 publications

References 39 publications

Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization

Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization

Antidepressant effects of resveratrol in an animal model of depression

The pharmacology of resveratrol in animals and humans

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