Antidepressant-like effect of Lafoensia pacari A. St.-Hil. ethanolic extract and fractions in mice

Abstract

These data indicate that the extract of Lafoensia pacari A. St.-Hil. possesses antidepressant-like properties in mice.

Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: Restoration of monoamine neurotransmitters in discrete brain regions

“…The number of ambulation (with at least three paws) and rearing (standing upright on hind paws), and the frequencies of grooming (including face cleaning, paw licking, fur licking, head scraping, and rubbing) were counted manually for 5 min as described in recent studies (Galdino et al, 2009;Tolardo et al, 2010). The apparatus was cleaned with 10% ethanol and dried thoroughly between tests.…”

Antigenotoxic, and anticytotoxic activities of an ethanolic extract of Lafoensia pacari (Lythraceae) stem bark in bacteria and mice

“…The phytochemical analysis of L. pacari stem bark revealed the presence of phenolic compounds, including flavonoids and tannins (Solon et al, 2000;Galdino et al, 2009). Previous studies have demonstrated that flavonoids and tannins have antioxidant activity, mainly due to their redox properties, absorbing or neutralizing free radicals that can attack biomolecules such as DNA (Degáspari and Waszczynskyj, 2004).…”

“…St.-Hil., popularly known in Brazil as "pacari", "dedaleiro", "didal" and "mangabeira-brava", is a medicinal plant of the family Lythraceae that is widely used as an antipyretic, wound healing, anti-inflammatory, and antidiarrheal agent, as well as in the treatment of gastritis and cancer (Sampaio et al, 2011). Infusion or maceration in white wine or in water for oral administration are the most common methods for preparing a remedy with this plant (Solon et al, 2000;Galdino et al, 2009).…”

“…The phytochemical analysis of L. pacari has revealed that this species contains phenolic compounds, mainly tannins and flavonoids (Solon et al, 2000;Galdino et al, 2009;Sampaio et al, 2011). It also possesses many biological properties, such as free radical scavenging (Solon et al, 2000), antidyspeptic (da Mota et al, 2006), anti-inflammatory (Rogerio et al, 2008), antidepressant-like (Galdino et al, 2009), and antifungal (Silva Junior et al, 2010) activities.…”

“…It also possesses many biological properties, such as free radical scavenging (Solon et al, 2000), antidyspeptic (da Mota et al, 2006), anti-inflammatory (Rogerio et al, 2008), antidepressant-like (Galdino et al, 2009), and antifungal (Silva Junior et al, 2010) activities. Nevertheless, so far and to the best of our knowledge, no studies of the genotoxic and antigenotoxic effects of L. pacari have been published.…”