Antidepressant-like effect of Kyllinga brevifolia rhizomes in male mice and chemical characterization of the components of the active ethyl acetate fraction

M.C., Hellión-Ibarrola; Montalbetti, Y.; O.Y., Heinichen; M.L., Kennedy; M.A., Campuzano; Alvarenga, Nelson; D.A., Ibarrola

doi:10.1016/j.jep.2016.10.086

Cited by 7 publications

(4 citation statements)

References 42 publications

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“…Such is the case of Valeriana officinalis, whose roots, rhizomes, and stolons have sesquiterpenes and iridoids such as valerenone, valerianol, valerenic acid among others, which have shown some GABAergic activity, reducing anxiety levels 6 ; Passiflora incarnata, whose aerial parts contain flavonoids and alkaloids to which the sedative and anxiolytic effects are attributed 7 , among others. In our research group, we have previously investigated the anxiolytic-like effect of Kyllinga brevifolia rhizomes 8 ; and Aloysia polystachya leaves extract 9 , and both demonstrated the ability to reduce anxiety and also antidepressant like effect [10][11][12] .…”

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confidence: 99%

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2021

IJPSR

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Anxiety disorders are among the most prevalent and high-cost diseases. Medicinal plants are a very good option to treat, and several have shown the ability to reduce anxiety. We report here the effect of A. gratissima var. gratissima (Agg) on behavior and anxiety in mice. The methanol extract of leaves was tested in order to verify the safety, effect on sleeping time and behavior. Anxiety was tested through the Open field, Hole board, and elevated plus maze tests, with 50, 100, 200, and 400 mg/kg of Agg, and diazepam as positive control drugs. The results showed that A. gratissima var. gratissima did not cause signs of toxicity or sedative effect, and the general behavior of mice was not altered with any dose. All doses of Agg and diazepam, after the mice were submitted to the Open field and Hole board, evidenced a significant increase in ambulation, and a significant decrease in immobility time, related to the control group. On Hole board, a significant increase in number and time spent in exploration indicated a possible anxiolytic-like effect, that was confirmed by the results obtained in the elevated plus-maze, where mice increased the number of entries and time spent in open arms, and decreased the number of entries and time spent in closed arms of the labyrinth. Al the results evidenced the safety of Agg, and denoted an anxiolytic-like effect in mice. INTRODUCTION:Anxiety disorders, affecting up to 33.7% of the population, are the most prevalent mental disorders and are associated with a high cost in health. A substantial underrecognition and under-treatment of these disorders have been demonstrated 1 . Persistent fretfulness, distractedness, and a sort of whole-body clenching to a full-blown panic attack constitute the variety of clinical manifestations of anxiety, which are indicators of a possible threat to homeostasis.

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confidence: 99%

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2021

IJPSR

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“…This impairment becomes evident when rodents are required to use brain regions such as the hippocampus and the surrounding cortex in tasks such as the navigation multiple maze test, in which they use the spatial relationships between the lanes to navigate to an exit. Cognitive deficiencies have also been reported in other behavioral tests, such as T-maze [4], radial maze [5], object recognition test [6], as well astests whose responses are not necessarily linked to thehippocampus and to the cerebral cortex [7].Stress, which is a condition, related to modern world dynamics, is another health issue affecting millions of people [8]. Stress may result from aparticular condition and/or lifestyle and may lead to a wide rangeof behavioral changes.…”

Section: Introductionmentioning

confidence: 93%

Starvation-induced Changes in Memory Sensitization, Habituation and Psychosomatic Responses

Ilochi

Kolawole

Oluwatayo

et al. 2019

IJTDH

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Starvation is a global challenge. Nutritional status of an organism may influence its psychosocial behavior and other nervous system processes like motor responses and its ability to learn and memorize. This study determined the impact of starvation-induced stress on memory sensitization, habituation and psychosomatic responses in an experimental animal design. 25 wistar rats were randomly sampled and grouped into 1-control, 2- feed after 6 hours deprivation, 3-feed after12 hours deprivation, 4-feed after 18 hours deprivation and 5-feed after 24 hours deprivation. Behavioral tests carried out included the multiple maze tests and elevated plus maze test. Grip strength test was performed to determine neuromuscular response and endurance in all groups. Biochemical investigation of brain stress markers was done on the last day of the study. There was a significant (P≤0.05) enhancement in memory processes and anxiolytic behavior after 6 hours feed deprivation. An increase in antioxidants after 6 hours feed deprivation was suspected to be a compensatory response. A progressive decrease in memory facilitation, anxiolytic behavior and muscular strength was reported after 12, 18 and 24 hours feed deprivation. The increase in habituation and decrease in psychosomatic response was observed and appreciated as the duration of feed deprivation was increased. This study provided evidence about a possible link between memory processes and stress-related alterations in calcium, magnesium and nitric oxide. Starvation may impair learning, memory and motor responses, but this tendency is dependent on the extent of feed deprivation and nutrient depletion.

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“…Depression is a major global problem. Only 10% of individuals experience severe depression, whereas 90% of patients experience mild to moderate depression (Hellion et al, 2016). Depression is a significant illness that affects approximately 13-20% of the world's population.…”

Section: Introductionmentioning

confidence: 99%

A Literature Review: The Potential of Natural Ingredients as Antidepressants

Puruhita,

Sri Wahyuni,

Suhendi

2023

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Changes in mood, physical well-being, and behavior, such as sleep and hunger patterns, psychomotor abilities, concentration, anhedonia, exhaustion, hopelessness, helplessness, and suicidal thoughts, define a mental illness known as depression. Alternative therapies that can be used to avoid these side effects include herbal medicines from several types of plants. This literature review aims to determine the potential of natural ingredients that have antidepressant activity in plant biomarkers, methods of obtaining biomarkers, effective dose, and their mechanisms of action. Article searches use keywords ("Herbal plant" OR "Medicinal plant" OR "Herbal" OR "Plant Extract" OR "Plant Extracts") AND ("Antidepressant" OR "Antidepressive") AND ("Mechanism of antidepressant") using the Science Direct, PubMed, and Google Scholar databases. The final results included eight research articles in the systematic review that met the inclusion criteria. Plants that have antidepressant potential include flowers of Viola odorata L, Crocus sativus, Impatiens glandulifera, and Leptadenia hastata (Pers.) and Alpinia zerumbet, seeds of Nigella sativa, root of Panax ginseng, and Achyranthes aspera. Keywords: Antidepressants, Natural Ingredients, Literature Review

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Antidepressant-like effect of Kyllinga brevifolia rhizomes in male mice and chemical characterization of the components of the active ethyl acetate fraction

Cited by 7 publications

References 42 publications

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Starvation-induced Changes in Memory Sensitization, Habituation and Psychosomatic Responses

A Literature Review: The Potential of Natural Ingredients as Antidepressants

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