Antidepressant-like effect of harmane and other β-carbolines in the mouse forced swim test

Farzin, Davood; Mansouri, Neda

doi:10.1016/j.euroneuro.2005.08.005

Cited by 138 publications

(106 citation statements)

References 41 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…To our knowledge, the use of AYA in a controlled clinical setting in patients with current depression --or in any other clinical population --has never been investigated. Moreover, the results of the present study, although preliminary, are corroborated by mounting research showing antidepressive potentials for AYA alkaloids in nonhuman animals [16][17][18][19][20][21][22][23][24] and in humans. 13,25,26 Finally, the reported results may prompt novel research into substances with faster therapeutic actions than currently available pharmacological resources, thus making antidepressive treatment more effective.…”

Section: Discussionsupporting

confidence: 71%

“…4,5 Studies conducted in rodents by our group and by others using doses of 10-15 mg/kg harmine have demonstrated antidepressive effects for this compound, which were associated with increases in BDNF levels. 17,19,21 Furthermore, harmine, THH, and harmaline are potent natural, selective, reversible, and competitive inhibitors of the MAO enzyme, especially of the MAO-A subtype. 9,36 THH acts as a selective serotonin reuptake inhibitor as well as an MAOI.…”

Section: Discussionmentioning

confidence: 99%

“…[16][17][18][19][20][21][22][23][24] Furthermore, a double-blind, placebo-controlled animal study reported reduced hopelessness and panic-related signs after acute AYA administration, 25 and preliminary data in humans also support an antidepressive action for AYA. 26 The agonist action of AYA alkaloids on serotonergic receptors and its inhibitory effects on MAO-A, associated with field and laboratory evidence suggesting that AYA causes a sensation of well-being, led to the hypothesis that this substance could be useful in the treatment of depression in humans.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

Osório

Sanches

Macedo

et al. 2015

Rev. Bras. Psiquiatr.

376

311

View full text Add to dashboard Cite

Objectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. Methods: Open-label trial conducted in an inpatient psychiatric unit. Results: Statistically significant reductions of up to 82% in depressive scores were observed between baseline and 1, 7, and 21 days after AYA administration, as measured on the Hamilton Rating Scale for Depression (HAM-D), the Montgomery-Å sberg Depression Rating Scale (MADRS), and the Anxious-Depression subscale of the Brief Psychiatric Rating Scale (BPRS). AYA administration resulted in nonsignificant changes in Young Mania Rating Scale (YMRS) scores and in the thinking disorder subscale of the BPRS, suggesting that AYA does not induce episodes of mania and/or hypomania in patients with mood disorders and that modifications in thought content, which could indicate psychedelic effects, are not essential for mood improvement. Conclusions: These results suggest that AYA has fast-acting anxiolytic and antidepressant effects in patients with a depressive disorder.

show abstract

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

Osório

Sanches

Macedo

et al. 2015

Rev. Bras. Psiquiatr.

376

311

View full text Add to dashboard Cite

show abstract

“…The whole plants of P. harmala have also been used as folk medicine in Turkey and Iran (Hemmateenejad et al, 2006;Kartal et al, 2003). Pharmacological studies on extracts and alkaloids separated from P. harmala have shown some biological activity and pharmacological effects, such as anti-tumor and analgesic effects Sobhani et al, 2002;Farouk (wileyonlinelibrary.com) DOI 10.1002/bmc.3218 et al, 2008, vasorelaxant activities (Astulla et al, 2008), antimicrobial and antifungal activities (Darabpour et al, 2011;Sarpeleh et al, 2009;Arshad et al, 2008), hypoglycemic effects (Singh et al, 2008), antidepressant effects (Farzin and Mansouri, 2006), hallucinogenic effects (Glennon et al, 2000), antileishmanial, insecticidal and repellent activities (Mohammad and Mazen, 2009) and promoting wound healing (Derakhshanfar et al, 2010), and were strong inhibitors of monoamine oxidase (Herraiz et al, 2010;Schwarz et al, 2003) and cholinesterase (Zheng et al, 2009(Zheng et al, , 2011Zhao et al, 2013). However, the seeds and aerial parts of P. nigellastrum and P. multisectum were sometimes used as substitutes of P. harmala in medicinal markets, which might result in inconsistencies in the clinical efficacy and therefore create a potential health hazard.…”

Section: Introductionmentioning

confidence: 96%

Chemical fingerprint and simultaneous determination of alkaloids and flavonoids in aerial parts of genus Peganum indigenous to China based on HPLC‐UV: application of analysis on secondary metabolites accumulation

Wen

Cheng

Liu

et al. 2014

Biomedical Chromatography

View full text Add to dashboard Cite

The aerial parts of genus Peganum are officially used in traditional Chinese medicine. The paper aims to establish a high-performance liquid chromatography (HPLC) method for fingerprint analysis and simultaneous determination of three alkaloids and two flavonoids in aerial parts of genus Peganum, and to analyze accumulative difference of secondary metabolites in inter-species, individuals of plants, inter-/intra-population and from different growing seasons. HPLC analysis was performed on a C18 column with gradient elution using 0.1% trifloroacetic acid and acetonitrile as mobile phase and detected at 265 nm, by conventional methodology validation. For fingerprint analysis, the RSDs of relative retention time and relative peak area of the characteristic peaks were within 0.07-0.78 and 0.94-9.09%, respectively. For simultaneous determination of vasicine, harmaline, harmine, deacetylpeganetin and peganetin, all calibration curves showed good linearity (r > 0.9990) within the test range. The relative standard deviations of precision, repeatability and stability test did not exceed 2.37, 2.68 and 2.67%, respectively. The average recoveries for the five analytes were between 96.47 and 101.20%. HPLC fingerprints play a minor role in authenticating and differentiating the herbs of different species of genus Peganum. However, the secondary metabolites levels of alkaloids and flavonoids in aerial parts of genus Peganum rely on species-, habitat-, and growth season-dependent accumulation.

show abstract

“…This alkaloid acts on CNS inhibiting the monoamino-oxidase (MAO) (Breakefield et al 1976, Pires et al 2010). Inhibitors of MAO induce an enhancement of the amine concentration in brain, mainly dopamine, noradrenalin and serotonin, generating a state of excitement, euphoria, increased psychomotor activity (antidepressant), and others (Farzin and Mansouri 2006). It is also observed hallucinogenic effect attributed to structural similarity with endogenous amines, such as tryptamine and serotonin (Fortunato 2009).…”

mentioning

confidence: 99%

Psychotria viridis: Chemical constituents from leaves and biological properties

Soares

Duarte

Cavalcanti

et al. 2017

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1 H and 13 C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1.

show abstract

Antidepressant-like effect of harmane and other β-carbolines in the mouse forced swim test

Cited by 138 publications

References 41 publications

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

Chemical fingerprint and simultaneous determination of alkaloids and flavonoids in aerial parts of genus Peganum indigenous to China based on HPLC‐UV: application of analysis on secondary metabolites accumulation

Psychotria viridis: Chemical constituents from leaves and biological properties

Contact Info

Product

Resources

About