Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice

Kudryashov, N. V.; Калинина, Татьяна Сергеевна; Shimshirt, A A; Королев, Антон Олегович; Волкова, А. В.; Воронина, Т. А.

doi:10.1097/fbp.0000000000000359

Cited by 12 publications

(8 citation statements)

References 32 publications

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“…Over the last three years, the FST has been used as the main test for evaluating both the modelling and drug-therapeutic efficiency. However, the main problem with the studied drugs, including fluoxetine, tipepidine, and tramadol, was the low statistical power for clinical applications, which may not provide a direction for meta-analyses [91,92,93].…”

Section: Behavioral Testsmentioning

confidence: 99%

Selecting an Appropriate Animal Model of Depression

Hao

Sun

et al. 2019

IJMS

162

112

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Depression has become one of the most severe psychiatric disorders and endangers the health of living beings all over the world. In order to explore the molecular mechanism that underlies depression, different kinds of animal models of depression are used in laboratory experiments. However, a credible and reasonable animal model that is capable of imitating the pathologic mechanism of depression in mankind has yet to be found, resulting in a barrier to further investigation of depression. Nevertheless, it is possible to explain the pathologic mechanism of depression to a great extent by a rational modeling method and behavioral testing. This review aims to provide a reference for researchers by comparing the advantages and disadvantages of some common animal depression models.

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Section: Behavioral Testsmentioning

confidence: 99%

Selecting an Appropriate Animal Model of Depression

Hao

Sun

et al. 2019

IJMS

162

112

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“…Fluoxetine (100 mg) was combined with 40 ml of distilled water to prepare the drug solution, so there was 2.5 mg of the drug in each cc of solution [16]. After the preparation of these solutions, different doses were adjusted for each experimental group and orally gavaged daily at 9-12 A.M. for one week [17][18][19][20][21][22][23][24]. Animals received oral gavage of distilled water, herbal solution, and drug solution as follows: Group 1: distilled water gavage (the same volume as other groups) Group 2: 10 mg/kg of fluoxetine solution gavage Group 3: 10 mg/kg of herbal solution gavage Group 4: 5 mg/kg of herbal solution gavage Group 5: 2.5 mg/kg of herbal solution gavage…”

Section: Methodsmentioning

confidence: 99%

Anti-depressant Activity of Hydroalcoholic Extract of Asperula odorata L. in Mice

Nemati

Vatani

Abbasy

et al. 2021

GMJ

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Background: The relationship between the treatment of depression and plant-derived substances (e.g., flavonoids, coumarin, and scopoletin) has been demonstrated through interference with the monoamine system. The present study was planned to evaluate the anti-depressant effects of Asperula odorata L. plant through behavioral tests in mice. Material and Methods: In this experimental study, 35 male Syrian mice weighing 30-40 g were examined in five groups (n=7) as follow: received oral distilled water gavage (control), 10 mg/kg of fluoxetine solution gavage (reference standard), 10, 5, and 2.5 mg/kg of A. odorata L. extract gavage (treatment groups). After one week, all behavioral tests, including tail suspension test (TST), forced swimming test (FST), open field test (OFT), elevated plus maze test (EPMT), and fractionation tests were performed each morning for 4-6 h within five days. Results: The hydroalcoholic extract of A. odorata contained phenolic and flavonoid substances (Shinoda test confirmed flavonoid family). Administration of extract (10 and 5 mg/kg doses) versus fluoxetine (10 mg/kg dose) reduced the immobility of animals in both FST and TST (P<0.05). At the OFT, the administered extract increased the number of central square entries of animals with higher mobility (P<0.05). At a 10 mg/kg dose, the active flavonoid ingredients increased the mice's incline to entre and spent more time within no wall parts of EPMT (P<0.05). Conclusion: Our study suggests that the hydroalcoholic extract of A. odorata L. could have significant anti-depressant activity. [GMJ.2021;10:e2206]

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“…Дозы антидепрессантов были выбраны в соответствии с ранее проведенными исследованиями [15]. Выбор препаратов обусловлен следующими факторами: (1) амитриптилин -трициклический антидепрессант, неизбирательный ингибитор обратного захвата моноаминов с преобладанием седативного эффекта над стимулирующим, флуоксетин -селективный ингибитор обратного захвата серотонина с выраженным стимулирующим эффектом; (2) амитриптилин и флуоксетин являются эталонными препаратами при доклиническом изучении антидепрессивного эффекта новых соединений; (3) флуоксетин способен стимулировать нейростероидогенез в ЦНС -часть адаптивной реакции организма на стресс, что дополнительно обусловливает актуальность изучения взаимодействия флуоксетина и хронического стресса [16].…”

Section: веществаunclassified

“…Антидепрессивную активность изучали в модифицированном варианте теста «вынужденное плавание» для мышей [16]. Пластиковые цилиндры (высота 30 см, диаметр 10 см) на 20 см заполняли водой температурой 25 ± 1 o C. За сутки до проведения теста мышей помещали в цилиндры с водой на 5 мин, затем бережно высушивали и возвращали в боксы.…”

Section: тест «вынужденное плавание»unclassified

The behavioral and neurochemical aspects of the interaction between antidepressants and unpredictable chronic mild stress

et al. 2020

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The behavioral and neurochemical effects of amitriptyline (10 mg/kg, i.p.) and fluoxetine (20 mg/kg, i.p.) after single and chronic administration in the setting of unpredictable mild stress in outbred mice ICR (CD-1) were studied. After 28-day exposure to stress we observed an increase in depressive reactions in forced swim test in mice and decrease in serotonin (5-HT) and 5-oxyindol acetic acid (5-HIAA) levels in hippocampus, an increase in noradrenaline (NA) concentration in hypothalamus. Single and chronic administration of amitriptyline and fluoxetine led to shortening of immobilization and increase in swimming in forced swim test. The antidepressant-like effect of fluoxetine, but not of amitriptyline, after single injection coincided with an increase of 5-HT turnover in hippocampus. The chronic administration of the antidepressants caused an increase in NA levels in hypothalamus. Thus, antidepressant-like effect of amitriptyline and fluoxetine may arise from enhancement of stress-dependent adaptive mechanisms depleted by chronic stress.

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Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice

Cited by 12 publications

References 32 publications

Selecting an Appropriate Animal Model of Depression

Selecting an Appropriate Animal Model of Depression

Anti-depressant Activity of Hydroalcoholic Extract of Asperula odorata L. in Mice

The behavioral and neurochemical aspects of the interaction between antidepressants and unpredictable chronic mild stress

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