Antidepressant-like effect of cannabidiol injection into the ventral medial prefrontal cortex—Possible involvement of 5-HT1A and CB1 receptors

Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders

“…In agreement with this proposal, bilateral microinjections of CBD into the vmPFC induced antidepressant-like effect in rats submitted to the FST. This effect was blocked by pre-treatment with WAY100635 or by the CB 1 antagonist AM251 (Sartim et al, 2016). Since the antidepressant-like effect induced by the endogenous cannabinoid anandamide was also blocked by 5HT 1A receptor antagonist, it was hypothesized that CBD effects on 5HT 1A receptors would be due to indirect modulation of local 5-HT levels via CB 1 activation.…”

The Versatile 2‐Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5‐HT1A Receptor

“…WAY100635 per se did not induce any changes in mobility time relative to the control group. In comparison, the reference 5‐HT 1A ‐R agonist 8‐OH‐DPAT was less potent and efficacious (Figure ).…”

“…The antidepressant-like effecto f( S)-(+)-19 was significantly reduced by pretreatment with the 5-HT 1A -R antagonist WAY100635, which demonstrated the involvement of 5-HT 1A -R in the activity of (S)-(+)-19.W AY100635 per se did not induce any changes in mobility time relative to the control group. In comparison, the reference 5-HT 1A -R agonist8 -OH-DPAT [43] was less potent and efficacious( Figure 6).…”

“…WAY100635 (0.3 mg kg À1 )w as injected s.c. 15 min before the administration of (S)-(+)-19 or 8-OH-DPAT.T he doses of amitriptyline, 8-OH-DPAT,a nd WAY100635 were chosen on the basis of previously published data. [42,43,55,56] The volume administered was 0.1 mL/10 gbody weight.…”

Single and combined effects of plant‐derived and synthetic cannabinoids on cognition and cannabinoid‐associated withdrawal signs in mice

“…While evidence supporting the pharmacological effects of CBD as being mediated through CB 1 receptors is limited (but see Bisogno et al, ; Casarotto et al, ; Sartim et al, ), more compelling evidence attributes many of CBD's actions to interactions with other receptors. Three commonly reported receptor mechanisms for the pharmacological effects of CBD are (i) direct agonist action at 5‐HT 1A receptors (Russo et al, ; Gomes et al, ; Ward et al, ), (ii) direct agonist action at TRPV1 receptors (Costa et al, ; Pertwee et al, ) and (iii) inhibition of the equilibrative nucleoside transporter leading to indirect agonist activity at adenosine A 2A receptors (Carrier et al, ; El‐Remessy et al, ; Liou et al, ; Pandolfo et al, ).…”