Antidepressant-like effect of active fraction of Polyrhachisvicina Roger in a rat depression model

Wei, Guining; Chu, Shifeng; Su, Quang T.; Su, Hua; Lin, Ming-Hsiu; He, Fan; Liang, Wenjie; L, Gao; Zhoufeng, Huang; Xiao, Tan; Xiao, Lin; Xianbiao, Zeng; Bao-wei, Wei; Chen, Nai‐Hong

doi:10.1016/j.jtcm.2018.02.001

Cited by 10 publications

(1 citation statement)

References 49 publications

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“…A total of 4.5 g paste was emulsified with 100 mL 2.0% Tween-80 to obtain the active fraction of Polyrhachis vicina Rogers (AFPR). [15][16][17]…”

Section: Drug Preparationmentioning

confidence: 99%

Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression

He¹,

Han²,

Jia³

et al. 2023

DDDT

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To investigate the mechanisms of antidepressant action of active fraction of Polyrhachis vicina Rogers (AFPR) through network pharmacology, molecular docking and experimental validation. Methods: GC-MS was used to predict chemical compounds, corresponding databases were used to predict chemical compound targets and depression targets, Cytoscape software was used to construct and analyze the protein interaction network map, DAVID database was used to analyze gene ontology (GO) and KEGG signaling pathway, and AGFR software was used to perform molecular docking. Subsequently, the underlying action mechanisms of AFPR on depression predicted by network pharmacology analyses were experimentally validated in a CORT-induced depression model in vitro and in vivo. Results: A total of 52 potential targets of AFPR on antidepressant were obtained. GO is mainly related to chemical synaptic transmission, signal transduction and others. KEGG signaling pathways are mainly related to cAMP signaling pathway and C-type lectin receptor signaling pathway. The experiment results showed that AFPR significantly increased the expression of PRKACA, CREB and BDNF in mouse brain tissue and PC12 cells. Furthermore, after interfered of cAMP in PC12 cells, the decreased expression of PRKACA, CREB and BDNF was reversed by AFPR. Conclusion: AFPR may exert antidepressant effects through multiple components, targets and pathways. Furthermore, it could improve neuroplasticity via the cAMP signaling pathway to improve depression-like symptoms.

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“…A total of 4.5 g paste was emulsified with 100 mL 2.0% Tween-80 to obtain the active fraction of Polyrhachis vicina Rogers (AFPR). [15][16][17]…”

Section: Drug Preparationmentioning

confidence: 99%

Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression

He¹,

Han²,

Jia³

et al. 2023

DDDT

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Active fraction of Polyrhachis vicina Rogers (AFPR) suppressed breast cancer growth and progression via regulating EGR1/lncRNA-NKILA/NF-κB axis

Ming

et al. 2020

Biomedicine & Pharmacotherapy

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Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence

El-Marasy

Awdan

Hassan

et al. 2021

Chemico-Biological Interactions

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Antidepressant-like effect of active fraction of Polyrhachisvicina Roger in a rat depression model

Cited by 10 publications

References 49 publications

Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression

Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression

Active fraction of Polyrhachis vicina Rogers (AFPR) suppressed breast cancer growth and progression via regulating EGR1/lncRNA-NKILA/NF-κB axis

Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence

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