2023
DOI: 10.1021/acschemneuro.3c00108
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Antidepressant-like Effect of 1-(2-(4-(4-Ethylphenyl)-1H-1,2,3-triazol-1-yl)phenyl)ethan-1-one in Mice: Evidence of the Contribution of the Serotonergic System

Abstract: Major depressive disorder (MDD) is a psychiatric disorder that affects a large portion of the population, with dysregulation of the serotonergic system, which is deeply involved in both the pathophysiology of MDD and mechanism of action of many antidepressants. Current pharmacological therapies do not meet the neurobiological needs of all depressed individuals, making the development of new antidepressants necessary. In recent decades, compounds containing triazoles have become promising due to their range of … Show more

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Cited by 3 publications
(1 citation statement)
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“…[26][27][28] In recent years, our research group has focused on the synthesis of novel molecules containing the 1,2,3-triazole unit and assessing their biological properties to explore new avenues for their utilization. [29][30][31][32][33][34] According to the literature, in addition to the broad pharmacological applications of thiazolidines, combining them with other classes of molecules with established properties leads to the creation of intriguing hybrid derivatives. Examples include thiazole-thiazolidinedione hybrids, [35] spirothiazolidines, [36] and thiazolidinone Cu(II) and Fe(III) complexes designed to investigate interactions with DNA and serum albumins.…”
Section: Introductionmentioning
confidence: 99%
“…[26][27][28] In recent years, our research group has focused on the synthesis of novel molecules containing the 1,2,3-triazole unit and assessing their biological properties to explore new avenues for their utilization. [29][30][31][32][33][34] According to the literature, in addition to the broad pharmacological applications of thiazolidines, combining them with other classes of molecules with established properties leads to the creation of intriguing hybrid derivatives. Examples include thiazole-thiazolidinedione hybrids, [35] spirothiazolidines, [36] and thiazolidinone Cu(II) and Fe(III) complexes designed to investigate interactions with DNA and serum albumins.…”
Section: Introductionmentioning
confidence: 99%