Antidepressant-induced undesirable weight gain: Prevention with rimonabant without interference with behavioral effectiveness

Gobshtis, Nikolai; Ben‐Shabat, Shimon; Fride, Ester

doi:10.1016/j.ejphar.2006.10.028

Cited by 31 publications

(19 citation statements)

References 56 publications

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“…As shown by Nobrega and Coscina (1987), the effect of DMI decreasing body weight gain in rats seems to be due to a decreased food intake (Nobrega and Coscina 1987). This effect of DMI seems particularly important in rats, since with similar treatments, mice show initial decrease in body weight gain, but a significant increase after 2 months of treatment (Gobshtis et al 2007). Moreover, in human patients, treatment with DMI induces increase or not weight gain (Szarek and Brandt 1993).…”

Section: Discussionmentioning

confidence: 93%

Repeated Immobilization Stress Increases Nur77 Expression in the Bed Nucleus of the Stria Terminalis

et al. 2011

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The transcription factor Nur77 has been identified as a neuronal activation marker of stressful stimuli in the central nervous system. Nur77 plays a key role at all levels of the hypothalamus-pituitary-adrenal axis during the stress response. However, the participation of Nur77 in extra-hypothalamic responses to stress is unknown. In this study, we studied the impact of acute and repeated immobilization stress on Nur77 expression in the bed nucleus of stria terminalis (BNST), a region involved in autonomic, neuroendocrine, and behavioral responses to stress. After a single session of immobilization stress we observed a significant increase of Nur77-like immunoreactivity in the BNST. This effect is not lost with repeated exposure to stress, since Nur77-like immunoreactivity and Nur77 mRNA in BNST were increased after the fifteenth stress session. The administration of desipramine, a specific inhibitor of noradrenaline reuptake, prevented the increase in Nur77-like immunoreactivity and mRNA induced by stress in rats subjected to repeated exposure to immobilization stress. Our results show that acute and repeated stress modulates Nur77 expression in BNST and suggest that Nur77 participates in extra-hypothalamic responses to stress.

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Section: Discussionmentioning

confidence: 93%

Repeated Immobilization Stress Increases Nur77 Expression in the Bed Nucleus of the Stria Terminalis

et al. 2011

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“…Very recently, another study with a similar rationale as ours explored the interaction between SR141716 and fluoxetine or desipramine, respectively, in the FST using female Sabra mice. 40 Yet, Gobshtis et al could neither demonstrate an interaction between SR141716 and the antidepressant drugs, nor an effect of SR141716 (5 mg/kg) alone. Future studies have to elucidate whether the independence of antidepressant actions from endocannabinoid signaling also holds true for male mice and other kinds or different doses of antidepressants.…”

Section: Discussionmentioning

confidence: 96%

“…40 To examine if the genetic knockout of CB1 leads to a different reaction or sensitivity to antidepressants in the FST, female CB1 þ / þ and CB1 À/À mice were treated with the NA reuptake inhibitor desipramine (Figure 4).…”

Section: Effects Of Sr141716 On Fst Behavior Are Specific For Cb1 Recmentioning

confidence: 99%

Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice

et al. 2007

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Dysregulation of the endocannabinoid system is known to interfere with emotional processing of stressful events. Here, we studied the role of cannabinoid receptor type 1 (CB1) signaling in stress-coping behaviors using the forced swim test (FST) with repeated exposures. We compared effects of genetic inactivation with pharmacological blockade of CB1 receptors both in male and female mice. In addition, we investigated potential interactions of the endocannabinoid system with monoaminergic and neurotrophin systems of the brain. Naive CB1 receptor-deficient mice (CB1 À/À ) showed increased passive stress-coping behaviors as compared to wild-type littermates (CB1 þ / þ ) in the FST, independent of sex. These findings were partially reproduced in C57BL/6N animals and fully reproduced in female CB1 þ / þ mice by pharmacological blockade of CB1 receptors with the CB1 receptor antagonist SR141716. The specificity of SR141716 was confirmed in female CB1 À/À mice, where it failed to affect behavioral performance. Sensitivity to the antidepressants desipramine and paroxetine was preserved, but slightly altered in female CB1 À/À mice. There were no genotype differences between CB1 þ / þ and CB1 À/À mice in monoamine oxidase A and B activities under basal conditions, nor in monoamine content of hippocampal tissue after FST exposure. mRNA expression of vesicular glutamate transporter type 1 was unaffected in CB1 À/À mice, but mRNA expression of brain-derived neurotrophic factor (BDNF) was reduced in the hippocampus. Our results suggest that impaired CB1 receptor function promotes passive stress-coping behavior, which, at least in part, might relate to alterations in BDNF function.

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“…1) developed more than 35 years ago in Hebrew University and widely used for research in Israel. Sabra mice are commonly used in cannabinoid (Fride et al 1995;Fride et al 2003;Sumariwalla et al 2004;Avraham et al 2005;Gobshtis et al 2007; Kogan et al 2007), immunological (Berkowitz-Balshayi et al 1995;Castel et al 1997), antioxidant (Tirosh et al 1996;Dubnov et al 2000) anorexia (Bonne et al 2003), dermal (Touitou et al 2002), and other research fields (Shapira 1973). We recently used these animals to selectively breed a population of animals with prominent dominant and submissive features (Feder et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of the Behavioral and Biomolecular Parameters of Four Mouse Strains

et al. 2011

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The use of mice as experimental models in pharmacological and biochemical research began over 100 years ago, during which time different mice strains with specific features were developed. Numerous studies demonstrate that the pharmacological efficacy of various compounds significantly varies among different animal strains, a factor which must be considered when analyzing experimental data. The Sabra strain, developed more than 35 years ago, is widely used for research in Israel but has an unclear origin and is not characterized as well as other strains. Comparative analyses of the molecular characteristics of Sabra and other strains should help to understand their characteristics and to enhance the validity of their experimental use. Thus, four mouse strains-outbred ICR and Sabra as well as inbred C57Bl/6J and Balb/c were compared. Animals' weight, blood corticosterone and hippocampal BDNF mRNA levels were measured, and animals' behavior was compared using the EPM, open field, FST, and hot plate tests. We found that although Sabra mice are bigger and heavier than other tested lines, this is not reflected in behavior or in biomolecular features, wherein Sabra mice lay within the diapason of other tested animals. Thus, behavioral tests of anxiety-like behavior and locomotor activity revealed that Sabra mice scored close to the mean of all tested lines. Analysis of blood corticosterone levels did not show significant differences among tested strains. We also found a correlation between general and locomotor activity of the tested strains and their hippocampal BDNF mRNA expression. In summary, we may conclude that Sabra mice have traits similar to the better known lines, and therefore they are good subjects for neuroscience research.

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Antidepressant-induced undesirable weight gain: Prevention with rimonabant without interference with behavioral effectiveness

Cited by 31 publications

References 56 publications

Repeated Immobilization Stress Increases Nur77 Expression in the Bed Nucleus of the Stria Terminalis

Repeated Immobilization Stress Increases Nur77 Expression in the Bed Nucleus of the Stria Terminalis

Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice

Comparative Analysis of the Behavioral and Biomolecular Parameters of Four Mouse Strains

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