Antidepressant-induced sleep bruxism: Prevalence, incidence, and related factors

Uca, Ali Ulvi; Uğuz, Faruk; Kozak, Hasan Hüseyin; Gümüş, Haluk; Aksoy, Fadime; Seyithanoğlu, Abdullah; Kurt, Hatıce Guncu

doi:10.1016/j.jns.2015.08.316

Cited by 14 publications

(37 citation statements)

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“…Many case studies have reported that SB can emerge following the administration SSRI and SNRI, namely duloxetine, paroxetine and fluoxetine but large controlled studies are lacking. [28][29][30][31][32] Evidence has emerged showing that familial factors may contribute to the occurrence of SB, and this conclusion is important and opens the door for further genetic investigation. In fact, results show that relatives of SB positive probands have an increased risk of SB awareness compared to relatives of SB negative probands.…”

mentioning

confidence: 99%

Sleep Bruxism-Tooth Grinding Prevalence, Characteristics and Familial Aggregation: A Large Cross-Sectional Survey and Polysomnographic Validation

Khoury

Carrà

Huynh

et al. 2016

Sleep

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Study Objectives: Sleep bruxism (SB) is characterized by tooth grinding and jaw clenching during sleep. Familial factors may contribute to the occurrence of SB. This study aims are: (1) revisit the prevalence and characteristics of SB in a large cross-sectional survey and assess familial aggregation of SB, (2) assess comorbidity such as insomnia and pain, (3) compare survey data in a subset of subjects diagnosed using polysomnography research criteria. Methods: A sample of 6,357 individuals from the general population in Quebec, Canada, undertook an online survey to assess the prevalence of SB, comorbidities, and familial aggregation. Data on familial aggregation were compared to 111 SB subjects diagnosed using polysomnography. Results: Regularly occurring SB was reported by 8.6% of the general population, decreases with age, without any gender difference. SB awareness is concomitant with complaints of difficulties maintaining sleep in 47.6% of the cases. A third of SB positive probands reported pain. A 2.5 risk ratio of having a first-degree family member with SB was found in SB positive probands. The risk of reporting SB in first-degree family ranges from 1.4 to 2.9 with increasing severity of reported SB. Polysomnographic data shows that 37% of SB subjects had at least one first-degree relative with reported SB with a relative risk ratio of 4.625. Conclusions: Our results support the heritability of SB-tooth grinding and that sleep quality and pain are concomitant in a significant number of SB subjects.

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confidence: 99%

Sleep Bruxism-Tooth Grinding Prevalence, Characteristics and Familial Aggregation: A Large Cross-Sectional Survey and Polysomnographic Validation

Khoury

Carrà

Huynh

et al. 2016

Sleep

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“…Uca et al conducted a study with 807 participants, of which 506 were using antidepressants for at least 3 months. SB was diagnosed based on the criteria proposed by the AASM .…”

Section: Resultsmentioning

confidence: 99%

“…All included papers were classified as analytical cross‐sectional studies according to the JBI reviewers manual, with the enrolment of a total of 1656 participants. Studies were conducted in Brazil, Israel, Taiwan and Turkey and were published between the years of 2009 up to 2015. Moreover, two studies evaluated populations younger than 18 years old …”

Section: Resultsmentioning

confidence: 99%

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Association between psychotropic medications and presence of sleep bruxism: A systematic review

Melo

Dutra

Filho

et al. 2018

J of Oral Rehabilitation

101

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The purpose of this study was to systematically review the literature for studies that investigated the association between use of psychotropic medications and presence of sleep bruxism (SB). Observational studies were selected in a two-phase process. Searches were performed on six electronic databases, and a grey literature search was conducted on three databases. SB diagnosis was based on questionnaires or clinical examinations; no polysomnography examinations were performed. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional Studies. Overall quality of evidence was evaluated according to the Grading of Recommendations Assessment, Development and Evaluation criteria. Five analytical cross-sectional studies were included, evaluating antidepressants, anticonvulsants and psychostimulants. One study was judged as low risk of bias, three as moderate risk and one high risk. Antidepressants were evaluated in adult populations only; duloxetine (Odds Ratio [OR] = 2.16; 95% Confidence Interval [95% CI] = 1.12-4.17), paroxetine (OR = 3.63; 95% CI = 2.15-6.13) and venlafaxine (OR = 2.28; 95% CI = 1.34-3.86) were positively associated with SB risk. No increased odds of SB were observed considering use of citalopram, escitalopram, fluoxetine, mirtazapine and sertraline. With regard to anticonvulsants, only barbiturates were associated with SB in children (OR = 14.70; 95% CI = 1.85-116.90), while no increased odds were observed for benzodiazepine, carbamazepine and valproate. The only psychostimulant evaluated was methylphenidate, and an association with SB was observed in adolescents (OR = 1.67; 95% CI = 1.03-2.68). Findings from this SR suggested that medications such as duloxetine, paroxetine, venlafaxine, barbiturates and methylphenidate might be associated with SB; however, overall quality of evidence was considered very low, and therefore, caution is recommended.

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“…Interestingly, patients with RLS with augmentation are at high risk of developing impulsive behavior, suggesting that impulse control disorder and augmentation may share a common pathophysiology [116 && ]. Drug effects: Benzodiazepine may trigger/ exacerbate sleepwalking, occasionally also NSRED; antidepressants may exacerbate RBD, RLS, sleepwalking, and bruxism; neuroleptics can exacerbate RLS and bruxism; dopaminergic drugs may trigger/aggravate NSRED and bruxism [117,118].…”

Section: Etiologymentioning

confidence: 99%

Sleep-related movement disorders and disturbances of motor control

Bargiotas

Bassetti²

2017

Current Opinion in Neurology

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Purpose of reviewReview of the literature pertaining to clinical presentation, classification, epidemiology, pathophysiology, diagnosis, and treatment of sleep-related movement disorders and disturbances of motor control. Recent findingsSleep-related movement disorders and disturbances of motor control are typically characterized by positive motor symptoms and are often associated with sleep disturbances and consequent daytime symptoms (e.g. fatigue, sleepiness). They often represent the first or main manifestation of underlying disorders of the central nervous system, which require specific work-up and treatment. Diverse and often combined cause factors have been identified. Although recent data provide some evidence regarding abnormal activation and/or disinhibition of motor circuits during sleep, for the majority of these disorders the pathogenetic mechanisms remain speculative. The differential diagnosis is sometimes difficult and misdiagnoses are not infrequent. The diagnosis is based on clinical and video-polysomnographic findings. Treatment of sleeprelated motor disturbances with few exceptions (e.g. restless legs/limbs syndrome) are based mainly on anecdotal reports or small series. SummaryMore state-of-the-art studies on the cause, pathophysiology, and treatment of sleep-related movement disorders and disturbances of motor control are needed.

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Antidepressant-induced sleep bruxism: Prevalence, incidence, and related factors

Cited by 14 publications

References 0 publications

Sleep Bruxism-Tooth Grinding Prevalence, Characteristics and Familial Aggregation: A Large Cross-Sectional Survey and Polysomnographic Validation

Sleep Bruxism-Tooth Grinding Prevalence, Characteristics and Familial Aggregation: A Large Cross-Sectional Survey and Polysomnographic Validation

Association between psychotropic medications and presence of sleep bruxism: A systematic review

Sleep-related movement disorders and disturbances of motor control

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