Antidepressant-induced Remission of Gardner Diamond Syndrome

Abstract

We describe the clinical presentation of a 25-year-old female patient who presented in dermatology with recurrent episodes of painful ecchymotic bruising over the anterior aspect of both arms and face. On enquiry, these episodes were precipitated by emotional stress and were preceded with a history of fall from the stairs. The patient also had multiple stressors in her day-to-day life and symptoms of depression. A diagnosis of mild depressive disorder without somatic complaints and Gardner Diamond syndrome was made. The patient was started on antidepressants, which not only improved her mood symptoms but also caused a remission of her painful bruises.

Gardner-Diamond Syndrome in an Adolescent With Suicidal Ideation: A Case Report

“…In these cases, a decrease in psychiatric symptoms, a resolution of recurrent bruising and pain symptoms, and a decrease in recurrence of the disease was observed after treatment, with patients reporting feeling better. 5,[10][11][12] Consistent with these previous reports, we also observed that symptoms decreased and resolved following initiation of SSRI therapy.…”

A Long-Term Psychological Observation in an Adolescent Affected with Gardner Diamond Syndrome

“…The patients reported commonly disclose hysterical and psycho-infantile personality traits, emotional vulnerability, tendency to somatic reactions to emotional stimuli, sexual complains, feelings of hostility, dysphoric-explosive behaviour and obsessive-compulsive disorder. [ 5 6 7 8 ]…”

“…In some patients, psychotropic medications were successfully prescribed according to type of psychopathological disorders and psychotherapy was used to improved skin condition and psychic disorders. [ 6 8 ]…”

“…The patients reported commonly disclose hysterical and psychoinfantile personality traits, emotional vulnerability, tendency to somatic reactions to emotional stimuli, sexual complains, feelings of hostility, dysphoricexplosive behaviour and obsessive-compulsive disorder. [5][6][7][8] GDS patients undergo a diagnostic odyssey. Long-term medicalization of patients and their families, high social costs, frustration of the medical team, patient and family are commonly experienced.…”