Antidepressant effects on GABA-stimulated 36Cl− influx in rat cerebral cortex are altered after treatment with GABAA receptor antisense oligodeoxynucleotides

Role of GABA in anxiety and depression

“…Increased brainstem GABA-A a1, a3, b1, b2 and g2 subunits mRNA levels [Tanay et al, 1996[Tanay et al, , 2001] and hippocampal GABA-B1 expression [Sands et al, 2004] after chronic AD treatment in rats. Increased Cl À uptake in submissive rats after AD treatment [Malatynska et al, 1995[Malatynska et al, , 2000. Chronic (but not acute) AD antagonized behavioral hyperactivity in rats produced by GABAergic inhibition by picrotoxin [Plaznik et al, 1989].…”

“…Picrotoxin (Cl À channel blocker) FST in mice/rats [Aley and Kulkarni, 1989;Skrebuhhova et al, 1999] Reversed effects of muscimol, valproate, and other ADs in the FST and LH in rats [Borsini et al, 1986;Fernandez Teruel et al, 1988;Cannizzaro et al, 1993; see also Tunnicliff and Malatynska, 2003] Reversed AD effects of progesterone in FST in rats [Estrada-Camarena et al, 2002] Pentylenetetrazole (Cl À channel blocker) FST in rats [Cannizzaro et al, 1993;Skrebuhhova et al, 1999] Abbreviations as in Tables 2, 3. a See also interesting data on GABA-A receptor antisense nucleotides that attenuate AD-induced Cl À uptake in rats [Malatynska et al, 2000].…”

Antidepressants and Antipsychotic Drugs Colocalize with 5-HT3Receptors in Raft-Like Domains

“…Both an indirect modulation of ligand-gated ion channels, e.g., GABA A receptors, via endogenous neuroactive steroids (Uzunov et al, 1996;Romeo et al, 1998;Marx et al, 2003) and a direct modulation of members of this receptor family, e.g., the GABA A receptor (Korpi et al, 1995;Mozrzymas et al, 1999;Malatynska et al, 2000;Robinson et al, 2003) and the 5-HT 3 receptor (Fan, 1994;Breitinger et al, 2001;Eisensamer et al, 2003;Rammes et al, 2004), have been described. This inhibitory action at 5-HT 3 receptors has been observed for both antidepressants (Eisensamer et al, 2003) and antipsychotics (Rammes et al, 2004) independently of their chemical structure and pharmacodynamic properties.…”