Antidepressant Effects of Abscisic Acid Mediated by the Downregulation of Corticotrophin-Releasing Hormone Gene Expression in Rats

Qi, Cong-Cong; Zhang, Zhi; Fang, Hui; Liu, Ji; Zhou, Nan; Ge, Jin‐Fang; Chen, Fang-Han; Xiang, Cheng‐Bin; Zhou, Jiang‐Ning

doi:10.1093/ijnp/pyu006

Cited by 30 publications

(26 citation statements)

References 50 publications

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“…Based on a series of pioneer studies, Zocchi's group demonstrated that ABA may act as an endogenous cytokine in inflammatory responses and stimulate the expansion of human mesenchymal stem cells in human granulocytes . In addition, ABA may also play a role in the stress response by downregulating the expression of the corticotrophin‐releasing hormone gene in rats . In addition, a possible role for ABA for cancer treatment was proposed more than three decades ago in an issued US patent .…”

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confidence: 99%

Abscisic‐acid‐induced cellular apoptosis and differentiation in glioma via the retinoid acid signaling pathway

Zhou

et al. 2015

Intl Journal of Cancer

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Retinoid acid (RA) plays critical roles in regulating differentiation and apoptosis in a variety of cancer cells. Abscisic acid (ABA) and RA are direct derivatives of carotenoids and share structural similarities. Here we proposed that ABA may also play a role in cellular differentiation and apoptosis by sharing a similar signaling pathway with RA that may be involved in glioma pathogenesis. We reported for the first time that the ABA levels were twofold higher in low‐grade gliomas compared with high‐grade gliomas. In glioma tissues, there was a positive correlation between the ABA levels and the transcription of cellular retinoic acid‐binding protein 2 (CRABP2) and a negative correlation between the ABA levels and transcription of fatty acid‐binding protein 5 (FABP5). ABA treatment induced a significant increase in the expression of CRABP2 and a decrease in the expression of peroxisome proliferator‐activated receptor (PPAR) in glioblastoma cells. Remarkably, both cellular apoptosis and differentiation were increased in the glioblastoma cells after ABA treatment. ABA‐induced cellular apoptosis and differentiation were significantly reduced by selectively silencing RAR‐α, while RAR‐α overexpression exaggerated the ABA‐induced effects. These results suggest that ABA may play a role in the pathogenesis of glioma by promoting cellular apoptosis and differentiation through the RA signaling pathway.

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confidence: 99%

Abscisic‐acid‐induced cellular apoptosis and differentiation in glioma via the retinoid acid signaling pathway

Zhou

et al. 2015

Intl Journal of Cancer

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“…The presence of ABA in the brain tissues of rats and pigs has been reported in 1986 ( Le Page-Degivry et al, 1986 ). It has been indicated that exogenous administration of ABA improves learning capability and mood state of rats ( Qi et al, 2014 , 2015 ; Naderi et al, 2017 ). So, it may be a potential therapeutic molecule of memory enhancer, which could be used in memory deficits disease, e.g., Alzheimer disease, in future study.…”

Section: Discussionmentioning

confidence: 99%

Phytohormone Abscisic Acid Improves Spatial Memory and Synaptogenesis Involving NDR1/2 Kinase in Rats

Liu

Zou

et al. 2018

Front. Pharmacol.

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The abscisic acid (ABA) is a phytohormone involved in plant growth, development and environmental stress response. Recent study showed ABA can also be detected in other organisms, including mammals. And it has been reported that ABA can improve learning and memory in rats. In this study, we attempted to investigate the effects of ABA on the alternation of dendritic spine morphology of pyramidal neurons in developmental rats, which may underlie the learning and memory function. Behavior tests showed that ABA significantly improved spatial memory performance. Meanwhile, Golgi-Cox staining assay showed that ABA significantly increased the spine density and the percentage of mushroom-like spines in pyramidal neurons of hippocampus, indicating that ABA increased dendritic spine formation and maturation, which may contribute to the improvement of spatial memory. Furthermore, ABA administration increased the protein expression of NDR1/2 kinase, as well as mRNA levels of NDR2 and its substrate Rabin8. In addition, NDR1/2 shRNA prohibited the ABA-induced increases in the expression of NDR1/2 and spine density. Together, our study indicated that ABA could improve learning and memory in rats and the effect are possibly through the regulation of synaptogenesis, which is mediated via NDR1/2 kinase pathway.

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“…Although abscisic acid (ABA) and RA are direct derivatives of carotenoids and share a similar molecular structure (Bremner and McCaffery, 2008; Moise et al, 2009), recently we found a contrary role of ABA in regulating CRH expression compared with RA (Qi et al, 2015a). Under acute stress, ABA concentrations increased in the serum, but decreased in the hypothalamus and were accompanied by increased corticosterone in the serum and c-fos expression in the hypothalamus.…”

Section: Cis-elements and Transcription Factorsmentioning

confidence: 99%

Transcriptional regulation of corticotropin-releasing hormone gene in stress response

Zhou

Fang

2018

IBRO Reports

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As a central player of the hypothalamic-pituitary-adrenal (HPA) axis, the corticotropin -releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) determine the state of HPA axis and play a key role in stress response. Evidence supports that during stress response the transcription and expression of CRH was finely tuned, which involved cis-element-transcriptional factor (TF) interactions and epigenetic mechanisms. Here we reviewed recent progress in CRH transcription regulation from DNA methylation to classic TFs regulation, in which a number of paired receptors were involved. The imbalance of multiple paired receptors in regulating the activity of CRH neurons indicates a possible molecular network mechanisms underlying depression etiology and directs novel therapeutic strategies of depression in the future.

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Antidepressant Effects of Abscisic Acid Mediated by the Downregulation of Corticotrophin-Releasing Hormone Gene Expression in Rats

Cited by 30 publications

References 50 publications

Abscisic‐acid‐induced cellular apoptosis and differentiation in glioma via the retinoid acid signaling pathway

Abscisic‐acid‐induced cellular apoptosis and differentiation in glioma via the retinoid acid signaling pathway

Phytohormone Abscisic Acid Improves Spatial Memory and Synaptogenesis Involving NDR1/2 Kinase in Rats

Transcriptional regulation of corticotropin-releasing hormone gene in stress response

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