Antidepressant effects of a polysaccharide from okra (Abelmoschus esculentus (L) Moench) by anti-inflammation and rebalancing the gut microbiota

Yan, Tingxu; Nian, Tingting; Liao, Zhengzheng; Xiao, Feng; Wu, Bo; Bi, Kaishun; He, Bin; Jia, Ying

doi:10.1016/j.ijbiomac.2019.12.138

Cited by 67 publications

(43 citation statements)

References 33 publications

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“…Oxidative stress has an impact on neural function and the overwhelmed oxidative stress contributes to the pathogenesis of CNS diseases [ 29 , 30 , 31 , 32 , 33 ]. An elevated level of malondialdehyde (MDA) was noted in the prefrontal cortical tissues ( Figure 7 A) and urine ( Figure 7 B), but not serum ( Figure 7 C), in PCS mice.…”

Section: Resultsmentioning

confidence: 99%

“…Neuroinflammation represents an active player in the pathogenesis of CNS diseases; therefore, anti-inflammatory therapy is of benefit for disease control [ 23 , 31 , 32 , 33 ]. Serum levels of IL-1β protein ( Figure 9 A) and prefrontal cortical tissue levels of IL-1β mRNA ( Figure 9 B) and IL-1β protein ( Figure 9 C,D) were elevated in PCS mice.…”

Section: Resultsmentioning

confidence: 99%

“…The molecular and cellular bases of depression, oxidative stress, and neuroinflammation have a central role to initiate a series of biochemical events, which result in a negative impact on neural function and, consequently, behavioral change [ 23 , 29 , 30 , 31 , 32 , 33 ]. The resultant neuronal cell apoptosis and autophagy, dysregulated neurochemicals, impaired neurogenesis, disturbed synaptic connection, and disrupted blood–brain barrier all play substantial roles, while contributing to depression [ 23 , 26 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

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p-Cresol Sulfate Caused Behavior Disorders and Neurodegeneration in Mice with Unilateral Nephrectomy Involving Oxidative Stress and Neuroinflammation

Sun

Wang

et al. 2020

IJMS

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Protein-bound uremic toxins, such as p-cresol sulfate (PCS), can be accumulated with declined renal function and aging and is closely linked with central nervous system (CNS) diseases. In the periphery, PCS has effects on oxidative stress and inflammation. Since oxidative stress and inflammation have substantial roles in the pathogenesis of neurological disorders, the CNS effects of PCS were investigated in unilateral nephrectomized C57/BL/6 mice. Unlike intact mice, unilateral nephrectomized mice showed increased circulating levels of PCS after exogenous administration. Upon PCS exposure, the unilateral nephrectomized mice developed depression-like, anxiety-like, and cognitive impairment behaviors with brain PCS accumulation in comparison with the nephrectomy-only group. In the prefrontal cortical tissues, neuronal cell survival and neurogenesis were impaired along with increased apoptosis, oxidative stress, and neuroinflammation. Circulating brain-derived neurotrophic factors (BDNF) and serotonin were decreased in association with increased corticosterone and repressor element-1 silencing transcription factor (REST), regulators involved in neurological disorders. On the contrary, these PCS-induced changes were alleviated by uremic toxin absorbent AST-120. Taken together, PCS administration in mice with nephrectomy contributed to neurological disorders with increased oxidative stress and neuroinflammation, which were alleviated by PCS chelation. It is suggested that PCS may be a therapeutic target for chronic kidney disease-associated CNS diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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p-Cresol Sulfate Caused Behavior Disorders and Neurodegeneration in Mice with Unilateral Nephrectomy Involving Oxidative Stress and Neuroinflammation

Sun

Wang

et al. 2020

IJMS

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“…Pectin could reduce intestinal epithelial damage and inflammation, and improve intestinal immunity though upregulating the content of antibacterial peptides in the intestine and enhancing the expression of immune‐related genes 24,25 . The expression of inflammation‐related signaling pathways such as TLR 4 and pro‐inflammatory cytokines could be depressed by okra pectin (OP) 26 . Previously, the cytotoxic effect of crude pectin and purified pectin on human glioblastoma cells was compared, and it was reported that, even at low concentrations, purified pectin showed a cytotoxicity effect 27 .…”

Section: Introductionmentioning

confidence: 99%

Okra pectin relieves inflammatory response and protects damaged intestinal barrier in caerulein‐induced acute pancreatic model

Xiong

Zhang

et al. 2020

J Sci Food Agric

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BACKGROUNDProtecting the intestinal mucosa from being destroyed helps reduce the inflammation caused by acute pancreatitis (AP). In this study, whether okra pectin (OP) could attenuate the inflammation of AP through protecting the intestinal barrier was investigated.RESULTSOP was obtained from crude okra pectin (COP) through the purification by DEAE cellulose 52 column. Supplementation with OP or COP in advance reduced the severity of AP, as revealed by lower serum amylase and lipase levels, abated pancreatic edema, attenuated myeloperoxidase activity and pancreas histology. OP or COP inhibited the production of pancreatic proinflammatory cytokines, including tumor necrosis factor‐α and interleukin‐6. In addition, the upregulation of AP‐related proteins including ZO‐1, occludin, the antibacterial peptide‐defensin‐1 (DEFB1) and cathelicidin‐related antimicrobial peptide (CRAMP), as well as the histological examination of colon injuries, demonstrated that OP or COP provision could effectively maintain intestinal barrier function. Ultimately, dietary OP or COP supplementation could inhibit AP‐induced intestinal inflammation. For the above, the effect of OP was better than COP.CONCLUSIONDietary OP supplementation could be considered as a preventive method that effectively interferes with intestinal damage and attenuates inflammatory responses trigged by AP. © 2020 Society of Chemical Industry

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“…Okra, and polyphenolic compounds in okra (quercetin and rutin) improve dexamethasone-induced spatial memory impairment in MWM [ 36 ]. Okra polysaccharide [ 40 ] and seeds [ 41 ] alleviate depression- and anxiety-like behaviors in mice through its antioxidant and anti-inflammatory activities. Okra polysaccharide also improved HFD-induced cognitive deficits in Aβ 1–42 obese mice in novel object recognition and MWM tasks [ 42 ] In line with these evidences, the present study was undertaken to investigate the potential ameliorative effects of okra peel in chronic HFD-induced cognitive detriments in C57BL/6J mice using an MWM task.…”

Section: Introductionmentioning

confidence: 99%

Abelmoschus Esculentus (L.) Moench’s Peel Powder Improves High-Fat-Diet-Induced Cognitive Impairment in C57BL/6J Mice

Prom-in

Kaewsrichan

Wangpradit

et al. 2020

IJERPH

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Okra peel exhibits numerous therapeutic effects. This study explores the potential ameliorative effects of okra peel powder on high-fat-diet (HFD)-induced hypercholesterolemia and cognitive deficits. Thirty-six C57BL/6J male mice were randomly divided into six groups (n = 6 per group): (i) control, mice fed with a normal diet; (ii) HFD, mice fed with HFD; (iii) HFD-SIM, mice fed with HFD and given simvastatin (20 mg/kg/day); (iv) HFD-OP1; (v) HFD-OP2; (vi) HFD-OP3, mice fed with HFD and okra peel (200, 400, or 800 mg/kg/day, respectively). Following 10 weeks of treatments, the mice were subjected to the Morris water maze (MWM). Parameters such as weekly average body weight, food intake, and blood lipid profiles were also recorded. The HFD group showed a profound increase in total cholesterol and low-density lipoprotein concentration compared to the control group. All okra-treated and HFD-SIM groups performed better than the HFD group during acquisition trials, whereas only the HFD-OP1 produced a significantly higher number of entries into the platform zone during the probe trial. In sum, all three okra doses improved the learning ability of the mice. However, only the lowest dose of okra significantly improved the spatial reference memory retention.

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Antidepressant effects of a polysaccharide from okra (Abelmoschus esculentus (L) Moench) by anti-inflammation and rebalancing the gut microbiota

Cited by 67 publications

References 33 publications

p-Cresol Sulfate Caused Behavior Disorders and Neurodegeneration in Mice with Unilateral Nephrectomy Involving Oxidative Stress and Neuroinflammation

p-Cresol Sulfate Caused Behavior Disorders and Neurodegeneration in Mice with Unilateral Nephrectomy Involving Oxidative Stress and Neuroinflammation

Okra pectin relieves inflammatory response and protects damaged intestinal barrier in caerulein‐induced acute pancreatic model

Abelmoschus Esculentus (L.) Moench’s Peel Powder Improves High-Fat-Diet-Induced Cognitive Impairment in C57BL/6J Mice

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