Antidepressant, anxiolytic, antipyretic, and thrombolytic profiling of methanol extract of the aerial part of <i>Piper nigrum</i>: In vivo, in vitro, and in silico approaches

Emon, Nazim Uddin; Alam, Safaet; Rudra, Sajib; Riya, Susmita Roy; Paul, Avi; Hossen, S. M. Moazzem; Kulsum, Ummay

doi:10.1002/fsn3.2047

Cited by 34 publications

(25 citation statements)

References 70 publications

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“…It also offers further comprehensions into the potential mechanisms of action and binding manners within the enzyme binding pocket (Alam et al, 2021a). Negative binding reveals strong favorable ligand-receptor complex interactions (Emon et al, 2021b). The molecular docking revealed that there were strong binding affinities with the respective target proteins.…”

Section: Resultsmentioning

confidence: 99%

Computer-aided Approaches to Support the Ethnopharmacological Importance of Dillenia pentagyna Roxb.: An In silico Study

et al. 2021

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Dillenia pentagyna Roxb., a deciduous and medium sized tree, is an ethnobotanically important species of several Asian countries including Bangladesh, Srilanka, and India. Various parts of this endangered tree including leaf, bark, root etc. are used in folkloric medicine systems for a very long time. It is locally used in the treatment of pain, wound healing, diabetes, diarrhea and other disease states. Molecular docking is an important technique to validate the exerted pharmacological actions of a plant or specific phytoconstituents by assessing the binding affinity and interaction pattern between small molecules and particular target receptors. Thus, to justify the notable ethnobotanical importances of D. pentagyna, an in silico study was designed employing selected phytochemicals i.e. isorhamnetin, lupeol, quercetin, kaempferol, and betulin isolated from this plant based on previous literature searches. The molecular docking revealed strong binding affinities (-4.8 to -12.9 kcal/mol) with the respective target proteins: 2OYE, 6COX, 4YK5, 5ZHP, and 1A5H. Besides, in accordance with the Lipinski’s rules, all five selected compounds of D. pentagyna showed promising orally active drug-like characteristics. To recapitulate, the present study has been found parallel with the existing ethnobotanical significance of D. pentagyna as the source of pain, fever, thrombosis, and diarrhea management agent. Bangladesh Pharmaceutical Journal 24(2): 125-132, 2021

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Section: Resultsmentioning

confidence: 99%

Computer-aided Approaches to Support the Ethnopharmacological Importance of Dillenia pentagyna Roxb.: An In silico Study

et al. 2021

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“…Two types of drug design approaches are primarily available: structural and ligand based drug design [ 62 ]. In the previous research, researchers used ligand-based relations to pick a lead compound that demonstrated a strong affinity with the potassium channel (PDB: 4UUJ ) [ 63 ], human serotonin receptor (PDB: 5I6X ) [ 32 ] and COX-1 (PDB: 2OYE ) receptors [ 37 , 38 ]. The MAO receptor is used in this study because MAO-A is typically aimed at treating depression and anxieties [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

“…The period during which the immobility of animals recorded was 6 min. When the mice silently hung or remained motionless, they were considered immobile [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

CNS anti-depressant, anxiolytic and analgesic effects of Ganoderma applanatum (mushroom) along with ligand-receptor binding screening provide new insights: Multi-disciplinary approaches

Hossen

Islam

Hossain

et al. 2021

Biochemistry and Biophysics Reports

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This research was designed to evaluate the CNS depressant, anxiolytic, and analgesic action of aqueous and ethanol extract of Ganoderma applanatum , a valuable medicinal fungus used in multiple disorders belongs to Ganodermataceae family. Two extracts of G. applanatum were prepared using distilled water and ethanol as solvents and named AEGA and EEGA. Open field method, rotarod method, tail suspension method, and hole cross method were utilized for the CNS depressant action. In contrast, elevated plus-maze test and hole board method were utilized for the anxiolytic action. For determining the analgesic potential, acetic acid-induced writhing test, hot plate method, and tail immersion test were used. Besides, molecular docking has been implemented by using Discovery studio 2020, UCSF Chimera and PyRx autodock vina. At both doses (200 and 400 mg/kg) of AEGA and EEGA showed significant CNS depressant effect ( p < 0.05 to 0.001) against all four tests used for CNS depressant activity. Both doses of AEGA and EEGA exhibited important anxiolytic activity effect ( p < 0.05 to 0.001)against the EPM and hole board test. Both doses of AEGA and EEGA also exhibited a potential analgesic effect ( p < 0.05 to 0.001) against all three tests used for analgesic action. In addition, in the molecular docking the compounds obtained the scores of −5.2 to −12.8 kcal/mol. Ganoapplanin, sphaeropsidin D and cytosporone C showed the best binding affinity to the selected recptors. It can be concluded that AEGA and EEGA have potential CNS depressant, anxiolytic, and analgesic action, which can be used as a natural antidepressant, anxiolytic, and analgesic source.

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“…The forced swimming test method was considered for the CNS depressant activity ( Emon et al 2021 ). As per Section 2.4 , each group was treated.…”

Section: Methodsmentioning

confidence: 99%

Deciphering the CNS anti-depressant, antioxidant and cytotoxic profiling of methanol and aqueous extracts of Trametes versicolor and molecular interactions of its phenolic compounds

Hossen

Tanim

Hossain

et al. 2021

Saudi Journal of Biological Sciences

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The present study sought to evaluate the central nervous system (CNS) depressant, antioxidant, and cytotoxicity activity of methanol and aqueous extract of Trametes versicolor (METV and AETV). The CNS activity was assessed by the open field, hole-cross, forced swimming, thiopental sodium-induced sleeping time, hole-board, and rotarod tests in Swiss albino mice. For both extracts, a substantial decrease in locomotion was observed in open field and hole-cross tests. In addition, the molecular docking study has been implemented through Maestro V11.1. The higher dose of METV (400 mg/kg) and the lower dose of AETV (200 mg/kg) exhibited a significant decrease in immobility time in forced swimming test and increased prolongation of sleep in thiopental sodium-induced sleeping time test, respectively. In contrast, a moderate finding was observed for the hole-board and rotarod tests. Additionally, a significant DPPH scavenging assay and a high toxicity effect in brine shrimp lethality assay were observed. Besides, five phenolic compounds, namely baicalin, quercetin, catechin, p-hydroxybenzoic acid, and quinic acid, were used for the molecular docking study, whereas catechin demonstrated the highest binding affinity towards the targets. The findings conclude that the T. versicolor could be an alternative source for CNS anti-depressant and antioxidant activity.

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Antidepressant, anxiolytic, antipyretic, and thrombolytic profiling of methanol extract of the aerial part of Piper nigrum: In vivo, in vitro, and in silico approaches

Cited by 34 publications

References 70 publications

Computer-aided Approaches to Support the Ethnopharmacological Importance of Dillenia pentagyna Roxb.: An In silico Study

Computer-aided Approaches to Support the Ethnopharmacological Importance of Dillenia pentagyna Roxb.: An In silico Study

CNS anti-depressant, anxiolytic and analgesic effects of Ganoderma applanatum (mushroom) along with ligand-receptor binding screening provide new insights: Multi-disciplinary approaches

Deciphering the CNS anti-depressant, antioxidant and cytotoxic profiling of methanol and aqueous extracts of Trametes versicolor and molecular interactions of its phenolic compounds

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