Antidepressant and mental health care utilization in pregnant women with depression and/or anxiety: An interrupted time-series analysis

Trinh, Nhung T H; Nordeng, Hedvig; Bandoli, Gretchen; Eberhard‐Gran, Malin; Lupattelli, Angela

doi:10.1016/j.jad.2022.04.101

Cited by 9 publications

(14 citation statements)

References 21 publications

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“…We included pregnancies with valid MBRN record which lasted ≥32 weeks and had pregnancy outcomes between 2009 and 2018 with at least one outpatient visit for depression (ICD-10: F32 and F33; ICPC-2: P76) and/or anxiety (ICD-10: F40 and F41, ICPC-2: P74); and at least one AD prescription filled at any time in the six months (ie, 168 days) prior to pregnancy start -as done previously. 22,23 Because we do not have information on the indication of AD, the last two criteria maximize the possibility that ADs were filled to treat depression/anxiety. 23 The start of pregnancy was estimated from the date of delivery and gestational length estimated via ultrasound or reported last menstrual period date in case https://doi.org/10.2147/CLEP.S379370…”

Section: Pregnancy Cohortmentioning

confidence: 99%

“…22,23 Because we do not have information on the indication of AD, the last two criteria maximize the possibility that ADs were filled to treat depression/anxiety. 23 The start of pregnancy was estimated from the date of delivery and gestational length estimated via ultrasound or reported last menstrual period date in case https://doi.org/10.2147/CLEP.S379370…”

Section: Pregnancy Cohortmentioning

confidence: 99%

“…20 We excluded pregnancies in the same women with an interpregnancy interval of less than one year to avoid nonindependent observations (N=60). 23…”

Section: Dovepressmentioning

confidence: 99%

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Antidepressant Fill and Dose Trajectories in Pregnant Women with Depression and/or Anxiety: A Norwegian Registry Linkage Study

Trinh¹,

Nordeng²,

Bandoli³

et al. 2022

CLEP

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Background: Few studies investigated longitudinal antidepressant exposure during pregnancy and included dosage in the assessment. Methods: We conducted a nationwide, registry-linkage study in Norway using data on antidepressant prescription fills in pregnancies lasting ≥32 weeks in women with a delivery between 2009 and 2018 who had a depression/anxiety diagnosis and antidepressant fills prior to pregnancy. Information on antidepressant exposure by week (measured by filled prescriptions) and prescribed average daily dose was used in longitudinal k-means trajectory modelling for a 108-week time window from six months prior to pregnancy to one year after delivery. Factors associated with trajectory group membership were examined using multinomial logistic regression models. Results: We included 8,460 pregnancies in 8,092 women. Four antidepressant fill trajectories were identified based on filled antidepressant prescriptions: two distinct discontinuing patterns, one at around the start of pregnancy (30.4%) and one around the end of pregnancy (33.8%); one continuing pattern (20.6%); and one interrupting pattern (15.2%). Using average usual daily dose, we identified low dose discontinuing (60.3%), medium dose reducing (20.6%) and high dose continuing (15.2%) patterns. The multinomial logistic regressions showed that the fill trajectory group membership was strongly associated with: antidepressant type and dose prior to pregnancy and co-medication prior to pregnancy, maternal age, marital status, parity, previous pregnancy loss, and pregnancy planning. Conclusion: Longitudinal trajectory modelling revealed distinct antidepressant fill and dosage patterns in the period around pregnancy. Knowledge about factors associated with utilization trajectories might be useful for health-care personnel counselling women about antidepressant use in pregnancy.

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Section: Pregnancy Cohortmentioning

confidence: 99%

Section: Pregnancy Cohortmentioning

confidence: 99%

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Antidepressant Fill and Dose Trajectories in Pregnant Women with Depression and/or Anxiety: A Norwegian Registry Linkage Study

Trinh¹,

Nordeng²,

Bandoli³

et al. 2022

CLEP

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“…Die Postpartalzeit stellt bei vielen psychiatrischen Erkrankungen eine besondere Risikozeit dar. Eine Registerstudie aus Norwegen mit Einschluss von Frauen mit Depression oder Angststörung zeigte eine insgesamt in der Schwangerschaft reduzierte Nutzung von Behandlungsangeboten, jedoch eine postpartal deutlich erhöhte Nutzung, besonders wenn eine medikamentöse Behandlung durch die Schwangerschaft unterbrochen wurde [4].…”

Section: Introductionunclassified

Inanspruchnahme einer Spezialsprechstunde für psychisch kranke Eltern

Brandl

Reiche

Hullmeine

et al. 2023

Psychother Psychosom Med Psychol

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Zusammenfassung Hintergrund Eltern mit psychischen Erkrankungen haben in der Peripartalzeit einen großen Unterstützungsbedarf. Bislang gibt es nur wenige spezialisierte Angebote. In dieser Untersuchung wird eine Spezialsprechstunde für psychisch kranke Eltern ausgewertet. Methoden Es wurden demographische und krankheitsbezogene Daten der Patient*innen der Elternsprechstunde in der Psychiatrischen Universitätsklinik der Charité im St. Hedwig Krankenhaus (N=279) aus dem Zeitraum 06/2017 bis 12/2021 ausgewertet. Ergebnisse Die Sprechstunde wurde vor allem von Personen mit affektiven Störungen, hohem Bildungsgrad und guter Therapieadhärenz in Anspruch genommen. Personen mit Migrationshintergrund erhielten seltener eine ambulante Psychotherapie. Diskussion Die Daten zeigen eine hohe Inanspruchnahme des ambulanten Angebots, jedoch eher durch eine Population mit höherem sozioökonomischem Status. Aufgrund der klinischen Relevanz wäre ein Ausbau von Angeboten für Eltern wünschenswert.

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“…Furthermore, depression and anxiety are frequently underdiagnosed during pregnancy 4 . Additionally, concerns regarding medication safety rise during pregnancy and many patients discontinue their antidepressant or anxiolytic medications, increasing the risk of relapse 5 . In Switzerland, one in six pregnant people require mental health services each year, with depression being the most prevalent perinatal mental health related diagnosis 6 .…”

Section: Introductionmentioning

confidence: 99%

Mental health in pregnant individuals during the COVID-19 pandemic based on a Swiss online survey

Favre

Kunz

Schwank

et al. 2022

Sci Rep

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The aim of our study was to evaluate the mental health of pregnant individuals during the early COVID-19 pandemic and the potential factors associated. A Swiss online survey was proposed to individuals who gave birth during the pandemic period from March 2020. The Edinburgh Postnatal Depression Scale (EPDS), Generalized Anxiety Disorder 7 questions (GAD-7), and Impact Event Scale-Revised (IES-R) were evaluated and used to defined mental health impairment as a composite outcome. From October, 2020 to February, 2021, 736 participants responded. The anxiety GAD-7 score was moderate in 9.6% and severe in 2.0%. The EPDS was moderate in 21.5% and severe in 32.9%. The IES-R was moderate in 10.3% and severe in 3.9%. Mental health impairment was reported in 37.0%. The association between the risk of mental health impairment and foreign nationality was significant (OR = 1.48; 95%CI [1.06–2.05]) as well as fetal and pregnancy worries because of coronavirus (OR = 1.46; 95% CI [1.08–1.98]) and 1.65; 95% CI [1.22–2.24]). Adjusted ORs were significant for foreign nationality (aOR = 1.51; 95%CI [1.07–2.13]) and pregnancy worries because of coronavirus (aOR = 1.62; 95%CI [1.10–2.40]). Pregnant people and especially foreign national have a high risk of mental health impairment during the pandemic.

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Antidepressant and mental health care utilization in pregnant women with depression and/or anxiety: An interrupted time-series analysis

Cited by 9 publications

References 21 publications

Antidepressant Fill and Dose Trajectories in Pregnant Women with Depression and/or Anxiety: A Norwegian Registry Linkage Study

Antidepressant Fill and Dose Trajectories in Pregnant Women with Depression and/or Anxiety: A Norwegian Registry Linkage Study

Inanspruchnahme einer Spezialsprechstunde für psychisch kranke Eltern

Mental health in pregnant individuals during the COVID-19 pandemic based on a Swiss online survey

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