Antidepressant and antipsychotic medication errors reported to United States poison control centers

Kamboj, Alisha; Spiller, Henry A.; Casavant, Marcel J.; Chounthirath, Thiphalak; Hodges, Nichole L.; Smith, Gary A.

doi:10.1002/pds.4554

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…13 Based on the National Poison Data System in the United States from 2000 to 2012, Kamboj et al found that atypical antipsychotics-a group of psycholeptics were associated with 32.1% of medication errors among children aged 6 to 19 years, compared with 20.6% among adults aged 20 years or above. 44 Our results thus join the emerging literature in suggesting a pediatric-specific pattern concerning medication errors involving psycholeptics. Finding effective targeted strategies for reducing pertaining medication errors and associated harm is crucial.…”

Section: 41supporting

confidence: 80%

Patterns of medication errors involving pediatric population reported to the French Medication Error Guichet

Azar¹,

Allué

Valnet-Rabier

et al. 2021

Pharm Pract (Granada)

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Background: Medication error is a global threat to patient safety, particularly in pediatrics. Yet, this issue remains understudied in this population, in both hospital and community settings. Objectives: To characterize medication errors involving pediatrics reported to the French Medication Error Guichet, and compare them with medication errors in adults, in each of the hospital and community settings. Methods: This was a retrospective secondary data analysis of medication errors reported throughout 2013-2017. Descriptive and multivariate analyses were performed to compare actual and potential medication error reports between pediatrics (aged <18 years) and adults (aged >18 and <60 years). Two subanalyses of actual medication errors with adverse drug reaction (ADR), and serious ADR were conducted. Results: We analyzed 4,718 medication error reports. In pediatrics, both in hospital (n=791) and community (n=1,541) settings, antibacterials for systemic use (n=121, 15.7%; n=157, 10.4%, respectively) and wrong dose error type (n=391, 49.6%; n=549, 35.7%, respectively) were frequently reported in medication errors. These characteristics were also significantly more likely to be associated with reported errors in pediatrics compared with adults. In the hospital setting, analgesics (adjusted odds ratio (aOR)=1.59; 95% confidence interval (CI) 1.03:2.45), and blood substitutes and perfusion solutions (aOR=3.74; 95%CI 2.24:6.25) were more likely to be associated with reported medication errors in pediatrics; the latter drug class (aOR=3.02; 95%CI 1.59:5.72) along with wrong technique (aOR=2.28; 95%CI 1.01:5.19) and wrong route (aOR=2.74; 95%CI 1.22:6.15) error types related more to reported medication errors with serious ADR in pediatrics. In the community setting, the most frequently reported pediatric medication errors involved vaccines (n=389, 25.7%). Psycholeptics (aOR=2.42; 95%CI 1.36:4.31) were more likely to be associated with reported medication errors with serious ADR in pediatrics. Wrong technique error type (aOR=2.71; 95%CI 1.47:5.00) related more to reported medication errors with ADR in pediatrics. Conclusions: We identified pediatric-specific medication error patterns in the hospital and community settings. Our findings inform focused error prevention measures, and pave the way for interventional research targeting the needs of this population.

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Section: 41supporting

confidence: 80%

Patterns of medication errors involving pediatric population reported to the French Medication Error Guichet

Azar¹,

Allué

Valnet-Rabier

et al. 2021

Pharm Pract (Granada)

View full text Add to dashboard Cite

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Suspected suicides and suicide attempts involving antipsychotic or sedative-hypnotic medications reported to America’s Poison Centers, 2000–2021

Ybanez

Spiller

Badeti

et al. 2023

Clinical Toxicology

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A New Approach with Dried Plasma Spots: A Rapid Determination of Antidepressants and Antipsychotics by Fast GC–MS

Gouveia¹,

Santos

Borges³

et al. 2023

Bioanalysis

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Background: The increasing prevalence of poisoning cases related to antidepressants and antipsychotics has raised concerns. Methods: To address this issue, a new adaptation of the dried plasma spot technique was developed using a 24-well plate and fast gas chromatography-mass spectrometry. The method involves the optimization of extraction variables and sample preparation, and was successfully validated. Results: The limits of quantitation ranged from 20 to 60 ng/ml, and accuracy ranged from 87.8% to 112.2%. The technique was applied to 102 human plasma samples from suspected poisoning cases, with positivity of 90.2%. Conclusion: This method provides a cheap, easy to implement and fast approach, making it ideal for toxicological emergency laboratories and promoting valuable support for healthcare professionals managing poisoning cases involving antidepressants and antipsychotics.

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Antidepressant and antipsychotic medication errors reported to United States poison control centers

Cited by 3 publications

References 23 publications

Patterns of medication errors involving pediatric population reported to the French Medication Error Guichet

Patterns of medication errors involving pediatric population reported to the French Medication Error Guichet

Suspected suicides and suicide attempts involving antipsychotic or sedative-hypnotic medications reported to America’s Poison Centers, 2000–2021

A New Approach with Dried Plasma Spots: A Rapid Determination of Antidepressants and Antipsychotics by Fast GC–MS

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